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Ethnobotany and drug discovery: the experience of the US National Cancer Institute

Autor: G M, Cragg, M R, Boyd, J H, Cardellina, D J, Newman, K M, Snader, T G, McCloud

Publikováno v: Ciba Foundation symposium. 185

Between 1960 and 1981 the National Cancer Institute (NCI) screened 114,000 extracts of 35,000 plants, mainly collected in temperate regions. Of the three clinically active anticancer drugs so far discovered in that programme, none was isolated from a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::52fc86be610b35cd2f42edf11ed0c944
https://pubmed.ncbi.nlm.nih.gov/7736854

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Effects of genetic, epigenetic, and environmental factors on taxol content in Taxus brevifolia and related species

Autor: N C Wheeler, A J Hoover, A B Alvarado, K M Snader, S W Brobst, K Jech, S Masters

Publikováno v: Journal of natural products. 55(4)

The demand for taxol, a promising cancer chemotherapeutic agent, far exceeds supply. Presently, taxol is derived from the bark of the Pacific yew, Taxus brevifolia, a small, slow-growing evergreen tree native to the northwestern United States. Knowle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf83810f6e489e59cf724e283bd1ef0
https://pubmed.ncbi.nlm.nih.gov/1355111

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