Prenatal hypoxia leads to hypertension, renal renin-angiotensin system activation and exacerbates salt-induced pathology in a sex-specific manner

Autor: S. L. Walton, H. Bielefeldt-Ohmann, R. R. Singh, J. Li, T. M. Paravicini, M. H. Little, K. M. Moritz

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract Prenatal hypoxia is associated with growth restriction and adverse cardiovascular outcomes. Here, we describe renal and cardiovascular outcomes in ageing mouse offspring prenatally exposed to hypoxia (12% O2) from embryonic day 14.5 until bi

Externí odkaz: https://doaj.org/article/97cbf1cf9e1047368697e21dba9998c3

The effect of heavy prenatal alcohol exposure on adolescent body mass index and waist-to-height ratio at 12-13 years

Autor: N, Hayes, N, Reid, L K, Akison, K M, Moritz

Publikováno v: International journal of obesity (2005). 45(9)

Growing evidence suggests that prenatal alcohol exposure (PAE) has the potential to impact on a wide range of physical outcomes in offspring, including metabolism and body composition, although the evidence to-date is primarily from preclinical studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1c4549b9fce622343ae2bbcda03ec36
https://pubmed.ncbi.nlm.nih.gov/34226636

Differential effects of prenatal exposure to dexamethasone or cortisol on circulatory control mechanisms mediated by angiotensin II in the central nervous system of adult sheep

Autor: M, Dodic, A T, McAlinden, A J, Jefferies, E M, Wintour, M L, Cock, C N, May, R G, Evans, K M, Moritz

Publikováno v: The Journal of physiology. 571(Pt 3)

Prenatal exposure to elevated maternal glucocorticoids (dexamethasone (DEX) or cortisol (CORT)) for 2 days early in pregnancy can 'programme' alterations in adult offspring of sheep, including elevated arterial pressure. DEX treatment also results in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ab5c6f2b7e3a88eb222c60d1b2825ba
https://pubmed.ncbi.nlm.nih.gov/16423855

The effect of chronic and acute haemorrhage on erythropoietin in the neonatal lamb

Autor: K M, Moritz, G, Clemons, K, Tangalakis, E M, Wintour

Publikováno v: Journal of developmental physiology. 18(3)

In all mammalian species studied the haematocrit (hct) declines after birth in the absence of any known nutritional deficiencies. The glycoprotein hormone, erythropoietin (Epo), is essential for normal red blood cell production. The aims of this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2aa06956c737d3fc2bd4555c2a14e35c
https://pubmed.ncbi.nlm.nih.gov/1338733

Evaluation of TRPM2 Channel-Mediated Autophagic Signaling Pathway in Hippocampus and Cortex Tissues of Rat Offspring Following Prenatal Exposure to Elevated Alcohol Levels.

Autor: Uğuz AC; Department of Biophysics, School of Medicine, Karamanoğlu Mehmetbey University, Karaman, Türkiye., Okan A; Department of Histology and Embryology, School of Medicine, Yozgat Bozok University, Yozgat, Türkiye., Doğanyiğit Z; Department of Histology and Embryology, School of Medicine, Yozgat Bozok University, Yozgat, Türkiye., Yilmaz S; Department of Anatomy, School of Medicine, Yozgat Bozok University, Yozgat, Türkiye., Ateş Ş; Department of Anatomy, School of Medicine, Yozgat Bozok University, Yozgat, Türkiye., Arikan Söylemez ES; Department of Medical Biology, School of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Türkiye., Karabulut S; Department of Physiology, School of Medicine, Sivas Cumhuriyet University, Sivas, Türkiye., Kumru AS; Department of Pharmacology and Toxicology, School of Veterinary Medicine, Sivas, Türkiye., Espino J; Department of Physiology, Faculty of Science, University of Extremadura, Badajoz, Spain.

Publikováno v: Environmental toxicology [Environ Toxicol] 2024 Oct 10. Date of Electronic Publication: 2024 Oct 10.