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1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo

Autor: S A Lacy, M S Chen, Z H Li, K M Kent, William A. Lee, N Bischofberger, Dirk B. Mendel, K C Cundy, Michael J. M. Hitchcock, D.B. Barkhimer

Publikováno v: Antimicrobial Agents and Chemotherapy. 38:2387-2391

1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosi ne (cyclic [cHPMPC]) was evaluated as a novel antiviral agent in comparison with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC). Evaluation for in vitro activity against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5a4d4defc1c8e2dfc309f52d53a729
https://doi.org/10.1128/aac.38.10.2387

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Evaluating new devices. Acute (in-hospital) results from the New Approaches to Coronary Intervention Registry

Autor: G S Roubin, Robert D. Safian, K Detre, S B King, David R. Holmes, K M Kent, Donald S. Baim, Michael J. Cowley, A R Steenkiste, D Gallup

Publikováno v: Circulation. 89:471-481

BACKGROUND To be used optimally, new interventional devices (stent, lasers, atherectomy catheters) must be carefully evaluated in terms of optimal patient and lesion selection, technique of use, expected acute success and complications, and long-term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32605128cce0746cd6c588ac43a49a87
https://doi.org/10.1161/01.cir.89.1.471

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Three-year follow-up after intracoronary gamma radiation therapy for in-stent restenosis. Original WRIST. Washington Radiation for In-Stent Restenosis Trial

Autor: A E, Ajani, R, Waksman, A K, Sharma, D H, Cha, E, Cheneau, R L, White, D, Canos, A D, Pichard, L F, Satler, K M, Kent, E, Pinnow, J, Lindsay

Publikováno v: Cardiovascular radiation medicine. 2(4)

The Washington Radiation for In-Stent Restenosis Trial (WRIST) is a double-blinded randomized study evaluating the effects of intracoronary radiation therapy (IRT) in patients with in-stent restenosis (ISR).One hundred and thirty patients with ISR (1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f77490164d329c7413bdc9b0c723c617
https://pubmed.ncbi.nlm.nih.gov/12160759

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Are we making progress with percutaneous saphenous vein graft treatment? A comparison of 1990 to 1994 and 1995 to 1998 results

Autor: M K, Hong, R, Mehran, G, Dangas, G S, Mintz, A, Lansky, K M, Kent, A D, Pichard, L F, Satler, G W, Stone, M B, Leon

Publikováno v: Journal of the American College of Cardiology. 38(1)

We sought to determine whether strategies to reduce procedural distal embolization and late repeat revascularization have resulted in more favorable outcomes after saphenous vein graft (SVG) angioplasty.Angioplasty of SVG lesions has been associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51619926be3d68127dc1932316f9fcd0
https://pubmed.ncbi.nlm.nih.gov/11451265

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Lesion-to-lesion relationship of the restenosis process after placement of coronary stents

Autor: R, Hoffmann, G S, Mintz, T, Reineke, K M, Kent, A D, Pichard, L F, Satler, P, Hanrath, M B, Leon

Publikováno v: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac AngiographyInterventions. 51(3)

The interrelation between multiple stented lesions within one patient in the restenosis process is only partially understood. From 492 patients with follow-up angiograms after coronary stent placement, 115 patients underwent multilesion procedures in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fda58f61e1968afd591bec89b88d23c8
https://pubmed.ncbi.nlm.nih.gov/11387623

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Prognostic value of recurrent episodes of creatine kinase-MB elevation following repeated catheter-based coronary interventions

Autor: R, Kornowski, S, Fuchs, M K, Hong, R, Mehran, L F, Satler, A D, Pichard, K M, Kent, G W, Stone, M B, Leon

Publikováno v: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac AngiographyInterventions. 51(2)

Creatine kinase-MB (CK-MB) enzyme elevations were shown to affect cardiac prognosis following percutaneous coronary interventions (PCIs). This study examined whether recurrent episodes of CK-MB elevation following repeated PCIs may be associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62d0b0faa427f0fe1351c156b5f84d20
https://pubmed.ncbi.nlm.nih.gov/11025563

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Clinical outcomes following 'rescue' administration of abciximab in patients undergoing percutaneous coronary angioplasty

Autor: S, Fuchs, R, Kornowski, R, Mehran, L, Gruberg, L F, Satler, A D, Pichard, K M, Kent, G W, Stone, M B, Leon

Publikováno v: The Journal of invasive cardiology. 12(10)

Pre-intervention administration of abciximab in patients at "high risk" for coronary angioplasty has been shown to reduce acute and long-term cardiac outcomes. The role of intra-procedural ("rescue") administration of abciximab has not been fully elu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d60f899b0fc6d7b179b60d682e3851c6
https://pubmed.ncbi.nlm.nih.gov/11022208

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