Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin:A Metgen Meta-Analysis

Autor: T, Dujic, K, Zhou, S W, Yee, N, van Leeuwen, C E, de Keyser, M, Javorský, S, Goswami, L, Zaharenko, M M, Hougaard Christensen, M, Out, R, Tavendale, M, Kubo, M M, Hedderson, A A, van der Heijden, L, Klimčáková, V, Pirags, A, Kooy, K, Brøsen, J, Klovins, S, Semiz, I, Tkáč, B H, Stricker, Cna, Palmer, L M, 't Hart, K M, Giacomini, E R, Pearson

Publikováno v: Dujic, T, Zhou, K, Yee, S W, van Leeuwen, N, de Keyser, C E, Javorský, M, Goswami, S, Zaharenko, L, Hougaard Christensen, M M, Out, M, Tavendale, R, Kubo, M, Hedderson, M M, van der Heijden, A A, Klimčáková, L, Pirags, V, Kooy, A, Brøsen, K, Klovins, J, Semiz, S, Tkáč, I, Stricker, B H, Palmer, C N A, 't Hart, L M, Giacomini, K M & Pearson, E R 2017, ' Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin : A Metgen Meta-Analysis ', Clinical Pharmacology and Therapeutics, vol. 101, no. 6, pp. 763-772 . https://doi.org/10.1002/cpt.567
Clinical Pharmacology and Therapeutics, 101(6), 763-772
Dujic, T, Zhou, K, Yee, S W, van Leeuwen, N, de Keyser, C E, Javorský, M, Goswami, S, Zaharenko, L, Christensen, M M H, Out, M, Tavendale, R, Kubo, M, Hedderson, M M, van der Heijden, A A, Klimčáková, L, Pirags, V, Kooy, A, Brøsen, K, Klovins, J, Semiz, S, Tkáč, I, Stricker, B H, Palmer, C N A, 't Hart, L M, Giacomini, K M & Pearson, E R 2017, ' Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin : A MetGen Meta-Analysis ', Clinical Pharmacology & Therapeutics, vol. 101, no. 6, pp. 763-772 . https://doi.org/10.1002/cpt.567
Clinical pharmacology and therapeutics, vol 101, iss 6
Clinical Pharmacology & Therapeutics, 101(6), 763-772. Wiley-Blackwell
Clinical Pharmacology and Therapeutics, 101(6), 763-772. Wiley-Blackwell
Clinical Pharmacology and Therapeutics

Therapeutic response to metformin, a first-line drug for type 2 diabetes (T2D), is highly variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have mainly focused on the impact of variants in metformin transport

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b762e525da754cb923dd8b91cd06ac1f
https://research.vumc.nl/en/publications/508fedaf-498a-4e2d-91a9-f7fedd97684b

Verapamil interacts stereoselectively with the muscarinic receptor

Autor: J C, Giacomini, R H, Zobrist, B, Dave, K M, Giacomini

Publikováno v: Pharmaceutical research. 2(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f1d72e884835b21881e255a8090e3a7
https://pubmed.ncbi.nlm.nih.gov/24272619

Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters

Autor: M J, Dresser, M K, Leabman, K M, Giacomini

Publikováno v: Journal of pharmaceutical sciences. 90(4)

Transporters in the kidney mediate the secretion or reabsorption of many compounds and thereby influence the plasma levels of their substrates. Organic anion transporters and organic cation transporters are two major classes of secretory transporters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19a915e6fe1380c5825b7eb5afab0f77
https://pubmed.ncbi.nlm.nih.gov/11170032

Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes

Autor: M J, Dresser, K M, Gerstin, A T, Gray, D D, Loo, K M, Giacomini

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 28(9)

Nucleoside transporters that mediate cellular uptake of therapeutic nucleoside analogs are major determinants of the pharmacokinetic properties of these compounds. Understanding the substrate selectivity of these transporters is critical in the devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a766499cd4f0fe11214eafdb396102a
https://pubmed.ncbi.nlm.nih.gov/10950861

Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1)

Autor: M J, Dresser, A T, Gray, K M, Giacomini

Publikováno v: The Journal of pharmacology and experimental therapeutics. 292(3)

Organic cation transporters play an important role in the absorption, distribution, and elimination of clinical agents, toxic substances, and endogenous compounds. In kidney preparations, significant differences in functional characteristics of organ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f0d48ca52ea593ce983c279e39b83b5
https://pubmed.ncbi.nlm.nih.gov/10688634