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Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms

Autor: K. M. Curnow

Publikováno v: Molecular Endocrinology. 9:1250-1262

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2a9c4cedc10c617922f416fe65570a5
https://doi.org/10.1210/me.9.9.1250

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Genetic analysis of the human type-1 angiotensin II receptor

Autor: K. M. Curnow

Publikováno v: Molecular Endocrinology. 6:1113-1118

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86b0365a1605996fbcd007606b25da8b
https://doi.org/10.1210/me.6.7.1113

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Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11beta-hydroxylase) and CYP11B2(aldosterone synthase) cause steroid 11beta-hydroxylase deficiency and congenital adrenal hyperplasia

Autor: S, Portrat, P, Mulatero, K M, Curnow, J L, Chaussain, Y, Morel, L, Pascoe

Chromosomal rearrangements are natural experiments that can provide unique insights into in vivo regulation of genes and physiological systems. We have studied a patient with congenital adrenal hyperplasia and steroid 11beta-hydroxylase deficiency wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e61be17a18e4023336d705779aca65bc
http://hdl.handle.net/2318/32737

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Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol

Autor: P, Mulatero, K M, Curnow, B, Aupetit-Faisant, M, Foekling, C, Gomez-Sanchez, F, Veglio, X, Jeunemaitre, P, Corvol, L, Pascoe

CYP11B1 (11beta-hydroxylase) and CYP11B2 (aldosterone synthase) are 93% identical mitochondrial enzymes that both catalyze 11beta-hydroxylation of steroid hormones. CYP11B2 has the additional 18-hydroxylase and 18-oxidase activities required for conv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::58f2a9bd098e9f424a61b7988d32ec7c
http://hdl.handle.net/2318/41859

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Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling. Reconstitution of the binding site by co-expression of two deficient mutants

Autor: C, Monnot, C, Bihoreau, S, Conchon, K M, Curnow, P, Corvol, E, Clauser

Publikováno v: The Journal of biological chemistry. 271(3)

Type 1 angiotensin receptors (AT1) are G-protein coupled receptors, mediating the physiological actions of the vasoactive peptide angiotensin II. In this study, the roles of 7 amino acids of the rat AT1A receptor in ligand binding and signaling were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::340e92c3abba6077d1330682f7e1838f
https://pubmed.ncbi.nlm.nih.gov/8576145

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Human type-1 angiotensin II (AT1) receptor gene structure and function

Autor: K M, Curnow

Publikováno v: Clinical and experimental pharmacologyphysiology. Supplement. 3

1. The type-1 angiotensin II (AngII) receptors, designated AT(1), mediate most of the biological actions of the peptide hormone AngII. They are the most recent drug target for the treatment of hypertension and cardiac failure and basic research is no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::08fb919eff1a11b0f7b95fad6fb9d8b3
https://pubmed.ncbi.nlm.nih.gov/8993842

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Steroid 11β-Hydroxylase Isozymes (CYP11B1 and CYP11B2)

Autor: Perrin C. White, L. Pascoe, K. M. Curnow

Publikováno v: Cytochrome P450 ISBN: 9783642777653

Cortisol is synthesized from cholesterol in the zona fasciculata of the adrenal cortex under the control of corticotropin (ACTH) (reviewed in New et al. 1989). Synthesis of Cortisol requires five enzymatic steps (Fig. 1): cleavage of the cholesterol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3206dc59b15d87d88091e8ab53cd3d4
https://doi.org/10.1007/978-3-642-77763-9_41

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Mapping of the MouseLy-6, Xp-14, andGdc-1 loci to chromosome 15

Autor: K. M. Curnow, I. E. C. McKenzie, P. M. Hogarth, E. M. Eicher, B. K. Lee, Vivien R. Sutton

Publikováno v: Immunogenetics. 25:21-27

The Ly-6 locus is now regarded as a gene complex consisting of at least five closely linked loci (Ly-6A-Ly-6E) whose polymorphic products are identified by monoclonal antibodies and distinguished by different tissue distributions. Ly-6 has been assig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8fd0ed6cde080721b75dfac8dcd21f
https://doi.org/10.1007/bf00768829

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Isolation of the CD7 gene from the DNA of transfected L cells

Autor: Ian Farquhar Campbell Mckenzie, Mauro S. Sandrin, K. M. Curnow, Nicholas J. Deacon, Claudia A. Mickelson, Hilary A. Vaughan, K. E. Lovering

Publikováno v: Immunogenetics. 25(6)

Using DNA from L cells which expressed high levels of the CD7 (Leu-9 or HuLy-m2) antigen obtained after two cycles of transfection, a genomic library was constructed in the lambda phage Charon 4A. Recombinant clones containing the gene coding for thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6c416b01ddfae9a559ea43a38399bf
https://pubmed.ncbi.nlm.nih.gov/2954903

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