Výsledky vyhledávání - "K M, Brinkhous"

Pharmacokinetics of Recombinant Factor IX after Intravenous and Subcutaneous Administration in Dogs and Cynomolgus Monkeys

Autor: J. Sigman, James C. Keith, K. M. Brinkhous, Robert G. Schaub, Kyle P. McCarthy, P. Stewart, M. Read, Timothy Nichols

Publikováno v: Thrombosis and Haemostasis. 87:824-830

SummaryHemophilia B therapy requires intravenous (IV) infusions of large volumes of factor IX due to the low concentration of factor IX in concentrates (∼100 IU/mL). High concentration recombinant factor IX (rFIX) could be a significant advance sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e27c7ff0db68bd089060a952d8a2574c
https://doi.org/10.1055/s-0037-1613091

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The roles of von Willebrand factor and factor VIII in arterial thrombosis: studies in canine von Willebrand disease and hemophilia A

Autor: T C, Nichols, D A, Bellinger, R L, Reddick, S V, Smith, G G, Koch, K, Davis, J, Sigman, K M, Brinkhous, T R, Griggs, M S, Read

Publikováno v: Blood. 81:2644-2651

We have studied the roles of von Willebrand factor (vWF) and factor VIII in arterial thrombosis in four canine phenotypes: normal (n = 6), hemophilia A (n = 11), von Willebrand disease (vWD) (n = 9), and hemophilia A/vWD (n = 1). vWF activity was det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c5575b867e5477429ceb8eeb9bf5cc
https://doi.org/10.1182/blood.v81.10.2644.bloodjournal81102644

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PROTHROMBIN DEFICIENCY THE CAUSE OF BLEEDING IN BILE FISTULA DOGS

Autor: W. B. Hawkins, K. M. Brinkhous

Publikováno v: The Journal of Experimental Medicine

The bleeding tendency that develops in bile fistula dogs, completely or partially deprived of bile, is due to a prothrombin deficiency of the blood plasma. However, a relatively low prothrombin level may exist in these animals without the occurrence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f43d639a4148766ec7869b588462b0
https://pubmed.ncbi.nlm.nih.gov/19870504

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Pharmacokinetics of recombinant factor IX after intravenous and subcutaneous administration in dogs and cynomolgus monkeys

Autor: K, McCarthy, P, Stewart, J, Sigman, M, Read, J C, Keith, K M, Brinkhous, T C, Nichols, R G, Schaub

Publikováno v: Thrombosis and haemostasis. 87(5)

Hemophilia B therapy requires intravenous (IV) infusions of large volumes of factor IX due to the low concentration of factor IX in concentrates (approximately 100 IU/mL). High concentration recombinant factor IX (rFIX) could be a significant advance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25e0406971a3c3b3319941a537ac5c12
https://pubmed.ncbi.nlm.nih.gov/12038784

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