Zobrazeno 1 - 10 of 107 pro vyhledávání: '"K M, Barone"'
1
Leukocyte recruitment into human skin transplanted onto severe combined immunodeficient mice induced by TNF-alpha is dependent on E-selectin
Autor: H C Yan, H M Delisser, J M Pilewski, K M Barone, P J Szklut, X J Chang, T J Ahern, P Langer-Safer, S M Albelda
Publikováno v: The Journal of Immunology. 152:3053-3063
In order to study the in vivo role of E-selectin in human inflammation, we have developed a model in which human skin is transplanted onto severe combined immunodeficient (SCID) mice. The grafted skin closely resembles normal skin and retains its hum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e528d179777b0572c07331d73b2c89b6
https://doi.org/10.4049/jimmunol.152.6.3053
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2
Protein engineering of novel plasminogen activators with increased thrombolytic potency in rabbits relative to activase
Autor: G A Timony, Glenn R. Larsen, K S Henson, J B Stoudemire, P G Horgan, K M Barone, L B Angus
Publikováno v: Journal of Biological Chemistry. 266:8156-8161
Human tissue-type plasminogen activator (t-PA) is a glycoprotein used currently in thrombolytic therapy for patients with acute myocardial infarction. Due to its rapid rate of clearance from the circulation, continuous intravenous administration of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2475c0babdb575e780a7ebe01126aade
https://doi.org/10.1016/s0021-9258(18)92955-8
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3
Replacement of finger and growth factor domains of tissue plasminogen activator with plasminogen kringle 1. Biochemical and pharmacological characterization of a novel chimera containing a high affinity fibrin-binding domain linked to a heterologous protein
Autor: L B Angus, Glenn R. Larsen, G E Morris, K M Barone, P G Horgan, Ahern Tim J, G A Timony, J B Stoudemire, M J Brenner, P R Langer-Safer
Publikováno v: Journal of Biological Chemistry. 266:3715-3723
A novel triple-kringle plasminogen activator protein, PK1 delta FE1X, has been produced which is a genetic chimera between the fibrin binding kringle 1 domain of plasminogen and the two kringles and serine protease domains of naturally occurring wild
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98115804d76878514ed49243b3cf5a94
https://doi.org/10.1016/s0021-9258(19)67853-1
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4
Site-directed mutagenesis in human tissue-plasminogen activator. Distinguishing sites in the amino-terminal region required for full fibrinolytic activity and rapid clearance from the circulation
Autor: L B Angus, J B Stoudemire, Ahern Tim J, G A Timony, G E Morris, K S Henson, P G Horgan, K M Barone, P R Langer-Safer, Glenn R. Larsen
Publikováno v: Journal of Biological Chemistry. 265:5540-5545
Recombinant variants of tissue plasminogen activator (t-PA) containing either substitutions or deletions of amino acids within the fibronectin finger-like domain (residues 6-50) were found to exhibit widely varying in vivo clearance profiles in rats
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eba31d8307d684ad1449c473dc2a798d
https://doi.org/10.1016/s0021-9258(19)39394-9
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5
Spectrum of sialylated and nonsialylated fuco-oligosaccharides bound by the endothelial-leukocyte adhesion molecule E-selectin. Dependence of the carbohydrate binding activity on E-selectin density
Autor: M, Larkin, T J, Ahern, M S, Stoll, M, Shaffer, D, Sako, J, O'Brien, C T, Yuen, A M, Lawson, R A, Childs, K M, Barone
Publikováno v: The Journal of biological chemistry. 267(19)
Carbohydrate recognition by the human endothelial-leukocyte adhesion molecule, E-selectin, has been investigated by binding studies using 3H-labeled Chinese hamster ovary cells expressing different levels of the transfected full-length adhesion molec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a79accc909be72fe092e8d845c8a8c55
https://pubmed.ncbi.nlm.nih.gov/1377689
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6
Replacement of finger and growth factor domains of tissue plasminogen activator with plasminogen kringle 1. Biochemical and pharmacological characterization of a novel chimera containing a high affinity fibrin-binding domain linked to a heterologous protein
Autor: P R, Langer-Safer, T J, Ahern, L B, Angus, K M, Barone, M J, Brenner, P G, Horgan, G E, Morris, J B, Stoudemire, G A, Timony, G R, Larsen
Publikováno v: The Journal of biological chemistry. 266(6)
A novel triple-kringle plasminogen activator protein, PK1 delta FE1X, has been produced which is a genetic chimera between the fibrin binding kringle 1 domain of plasminogen and the two kringles and serine protease domains of naturally occurring wild
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ed8a81927d955f666f56d9e573aea19
https://pubmed.ncbi.nlm.nih.gov/1847387
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7
Site-directed mutagenesis in human tissue-plasminogen activator. Distinguishing sites in the amino-terminal region required for full fibrinolytic activity and rapid clearance from the circulation
Autor: T J, Ahern, G E, Morris, K M, Barone, P G, Horgan, G A, Timony, L B, Angus, K S, Henson, J B, Stoudemire, P R, Langer-Safer, G R, Larsen
Publikováno v: The Journal of biological chemistry. 265(10)
Recombinant variants of tissue plasminogen activator (t-PA) containing either substitutions or deletions of amino acids within the fibronectin finger-like domain (residues 6-50) were found to exhibit widely varying in vivo clearance profiles in rats
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::449dc56bdfee8ee11724a1009bd4efe5
https://pubmed.ncbi.nlm.nih.gov/2108143
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8
Akademický článek
Anti-Inflammatory Potential of Fucoidan for Atherosclerosis: In Silico and In Vitro Studies in THP-1 Cells.
Autor: Huwait, Etimad1,2 (AUTHOR) dalal.alsaadi@hotmail.com, Al-Saedi, Dalal A.1,2 (AUTHOR), Mirza, Zeenat3,4 (AUTHOR) ehuwait@kau.edu.sa
Publikováno v: Molecules. May2022, Vol. 27 Issue 10, p3197-3197. 16p.
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9
Akademický článek
Geochemical Characteristics and Constraints on Provenance, Tectonic Setting, and Paleoweathering of Middle Jurassic Zhiluo Formation Sandstones in the Northwest Ordos Basin, North-Central China.
Autor: Cai, Yelei1 (AUTHOR) caiyelei1228@126.com, Ouyang, Fei1 (AUTHOR) lxr811@glut.edu.cn, Luo, Xianrong1 (AUTHOR) mlwen@glut.edu.cn, Zhang, Zilong2 (AUTHOR) zhangzilong@briug.cn, Wen, Meilan1 (AUTHOR) 15308383616@163.com, Luo, Xiaoneng2 (AUTHOR) lxnbriug@126.com, Tang, Rui1 (AUTHOR)
Publikováno v: Minerals (2075-163X). May2022, Vol. 12 Issue 5, p603-603. 24p.
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