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The importance of growth hormone replacement therapy for bone mass in young adults with growth hormone deficiency

Autor: K M, Attie

Publikováno v: Journal of pediatric endocrinologymetabolism : JPEM. 13

Growth hormone (GH) plays an important role in longitudinal bone growth in childhood, accrual of peak bone mass, and bone preservation in adults. GH deficiency (GHD) is associated with reduced bone turnover and decreased bone mineral density (BMD), e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7d745ea0002f839f00642684a1b2a4e
https://pubmed.ncbi.nlm.nih.gov/11086656

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High dose recombinant human growth hormone (GH) treatment of GH-deficient patients in puberty increases near-final height: a randomized, multicenter trial. Genentech, Inc., Cooperative Study Group

Autor: N, Mauras, K M, Attie, E O, Reiter, P, Saenger, J, Baptista

Publikováno v: The Journal of clinical endocrinology and metabolism. 85(10)

GH production rates markedly increase during human puberty, mostly as an amplitude-modulated phenomenon. However, GH-deficient children have been dosed on a standard per kg BW basis similar to prepubertal children. This randomized study was designed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6901775f7b1297cffdd82c72f8525d87
https://pubmed.ncbi.nlm.nih.gov/11061518

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Growth hormone therapy of Turner syndrome: the impact of age of estrogen replacement on final height. Genentech, Inc., Collaborative Study Group

Autor: S D, Chernausek, K M, Attie, J F, Cara, R G, Rosenfeld, J, Frane

Publikováno v: The Journal of clinical endocrinology and metabolism. 85(7)

Clinical trials of recombinant human GH therapy in Turner syndrome that began more than a decade ago show that GH accelerates the linear growth rate. Several studies indicate that final height is also improved, although the magnitude of the increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aebce20e90e60a5f4907951a7f7e4895
https://pubmed.ncbi.nlm.nih.gov/10902791

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Effect of growth hormone treatment on adult height of children with idiopathic short stature. Genentech Collaborative Group

Autor: R L, Hintz, K M, Attie, J, Baptista, A, Roche

Publikováno v: The New England journal of medicine. 340(7)

Short-term administration of growth hormone to children with idiopathic short stature results in increases in growth rate and standard-deviation scores for height. However, the effect of long-term growth hormone therapy on adult height in these child

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e55df1dfd6d1d2903ec22b45c2574e16
https://pubmed.ncbi.nlm.nih.gov/10021478

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Metabolic consequences of 5-year growth hormone (GH) therapy in children treated with GH for idiopathic short stature. Genentech Collaborative Study Group

Autor: P, Saenger, K M, Attie, J, DiMartino-Nardi, R, Hintz, L, Frahm, J W, Frane

Publikováno v: The Journal of clinical endocrinology and metabolism. 83(9)

In a multicenter study the metabolic effects of 5 yr of GH therapy in children with idiopathic short stature were evaluated. Patients received 0.3 mg/kg.week recombinant human GH. Of the 121 patients who entered the study, data for 62 were analyzed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb44d18f5e9b32613d65e3d87b0c841a
https://pubmed.ncbi.nlm.nih.gov/9745413

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Treatment of glucocorticoid-induced growth suppression with growth hormone. National Cooperative Growth Study

Autor: D B, Allen, J R, Julius, T J, Breen, K M, Attie

Publikováno v: The Journal of clinical endocrinology and metabolism. 83(8)

Growth failure is common during long term treatment with glucocorticoids (GC) due to blunting of GH release, insulin-like growth factor I (IGF-I) bioactivity, and collagen synthesis. These effects could theoretically be reversed with GH therapy. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12634fc625146eb840bda2aa1438ac9f
https://pubmed.ncbi.nlm.nih.gov/9709954

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Growth hormone treatment of girls with Turner syndrome: the National Cooperative Growth Study experience

Autor: L, Plotnick, K M, Attie, S L, Blethen, J P, Sy

Publikováno v: Pediatrics. 102(2 Pt 3)

To evaluate growth rate and adult height with recombinant growth hormone (GH) treatment in girls with Turner syndrome (TS) and predictors of their growth response.Data on girls with TS who were treated with GH in the National Cooperative Growth Study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a105e07e09ac8dedb1fa0ba6061a3e6
https://pubmed.ncbi.nlm.nih.gov/9685447

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Growth hormone therapy of Turner's syndrome: beneficial effect on adult height

Autor: K M Attie, A J Johanson, C P Mahoney, S Burstein, Ron G. Rosenfeld, W V Moore, R W Gotlin, P Saenger, B M Lippe, J Frane, S Chernausek, J A Brasel, J Kuntze, J F Cara

Publikováno v: The Journal of pediatrics. 132(2)

Objective: To carry out a multicenter, prospective, randomized trial of human growth hormone (GH), alone or in combination with oxandrolone (OX), in patients with Turner's syndrome (TS). Methods: In an initial phase lasting 12 to 24 months, 70 girls

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04652a5696b47ab3e88b3b74539003a9
https://pubmed.ncbi.nlm.nih.gov/9843362

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