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Identifying bias in CCR1 antagonists using radiolabeled binding, receptor internalization, β-arrestin translocation, and chemotaxis assays

Autor: Maria Rosa Mazzoni, A. Fazzini, Annette Gilchrist, K M Alley, J L Yarfi, D S Pyen, S J Ha, S E Sansom, J Ahn, T D Gauntner, J R Merritt, A Willett, Kelly A. Bachovchin

Publikováno v: British Journal of Pharmacology.

Background and Purpose Investigators have suggested that the chemokine receptor CCR1 plays a role in multiple myeloma. Studies using antisense and neutralizing antibodies to CCR1 showed that down-regulation of the receptor altered disease progression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bf2852ac826f60b512a9d7f838d9893
https://doi.org/10.1111/bph.12835

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Identifying bias in CCR1 antagonists using radiolabelled binding, receptor internalization, β-arrestin translocation and chemotaxis assays

Autor: A, Gilchrist, T D, Gauntner, A, Fazzini, K M, Alley, D S, Pyen, J, Ahn, S J, Ha, A, Willett, S E, Sansom, J L, Yarfi, K A, Bachovchin, M R, Mazzoni, J R, Merritt

Investigators have suggested that the chemokine receptor CCR1 plays a role in multiple myeloma. Studies using antisense and neutralizing antibodies to CCR1 showed that down-regulation of the receptor altered disease progression in a mouse model. More

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d4d31d699604170ff475c206a69f5d03
http://hdl.handle.net/11568/678292

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