Výsledky vyhledávání

Imaging of subclinical atherosclerosis - Impact on self-rated CVD risk and beliefs about possibilities to influence personal risk

Autor: E Andersson, S Nordin, K Lindvall, P Liv, U Naslund

Publikováno v: European Journal of Preventive Cardiology. 30

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): The Heart Foundation in Northern Sweden, Swedish Research Council. Background Adequate risk perception of cardiovascular disease (CVD) and beliefs about the possibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::060a87e67e87c144d341f29ba869f5d1
https://doi.org/10.1093/eurjpc/zwad125.061

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Akademický článek

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Supplementary Figures 1 - 4 from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers

Autor: Anne B. Jefferson, Cynthia M. Shafer, Eleni Venetsanakos, Elizabeth Ornelas, Catherine A. Luu, Mika K. Lindvall, Jiong Lan, William F. Estacio, Laura V. Doyle, Mercedita Del Rosario, Kenneth Crawford, Stephen E. Basham, Brent A. Appleton, Ida Aronchik

PDF file - 650K, Figure S1. RSK N-terminal Kinase Directly Phosphorylates YB1 on Ser102. COS7 cells either (A) untransfected or (B) transiently expressing WT RSK2 or T493M RSK2 were placed under serum starvation conditions for 20 hrs, followed by 3 h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0775c12e2c455a77f0f6170b2bd449e4
https://doi.org/10.1158/1541-7786.22511391

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Supplementary Methods from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ad7594fcd5df49250ddfdaff9459d2
https://doi.org/10.1158/1541-7786.22511388

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Supplementary Figure Legends from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers

PDF file - 74K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab586f9613d97b5fef19284a31f81a52
https://doi.org/10.1158/1541-7786.22511394

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Supplementary Table 2 from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers

PDF file - 28K, Percent Inhibition of MDA-MB-231 or H358 cells when grown as colonies on Scivax plates in the presence of LJI308.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac94484c1d0dc1a9aeed55e1da54f5f1
https://doi.org/10.1158/1541-7786.22511382

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Data from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers

The p90 ribosomal S6 kinase (RSK) family of serine/threonine kinases is expressed in a variety of cancers and its substrate phosphorylation has been implicated in direct regulation of cell survival, proliferation, and cell polarity. This study charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8ae1dcb5259c892f097fe0a3db0af33
https://doi.org/10.1158/1541-7786.c.6539931.v1

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Supplementary Table 1 from Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK-Driven Cancers

XLSX file - 27K, Competition binding of LJH685, LJI308, BI-D1870-AE, and FMK-PA at 10 microM concentration to either 96 or 492 kinases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c710e99010aa509d4e83e6d2196235f
https://doi.org/10.1158/1541-7786.22511385.v1

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Akademický článek

Inside the mind of a medicinal chemist: the role of human bias in compound prioritization during drug discovery.

Autor: Peter S Kutchukian, Nadya Y Vasilyeva, Jordan Xu, Mika K Lindvall, Michael P Dillon, Meir Glick, John D Coley, Natasja Brooijmans

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48476 (2012)

Medicinal chemists' "intuition" is critical for success in modern drug discovery. Early in the discovery process, chemists select a subset of compounds for further research, often from many viable candidates. These decisions determine the success of

Externí odkaz: https://doaj.org/article/8278d8c8630b4124807ed15a08836945

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