Zobrazeno 1 - 10
of 56
pro vyhledávání: '"K Leigh Greathouse"'
Autor:
K Leigh Greathouse, James Robert White, R Noah Padgett, Brittany G Perrotta, Gregory D Jenkins, Nicholas Chia, Jun Chen
Publikováno v:
BMJ Open Gastroenterology, Vol 6, Iss 1 (2019)
ObjectiveObesity is a risk factor for colorectal cancer (CRC), accounting for more than 14% of CRC incidence. Microbial dysbiosis and chronic inflammation are common characteristics in both obesity and CRC. Human and murine studies, together, demonst
Externí odkaz:
https://doaj.org/article/a55c0b97d9a745edb400c15b0e500a1c
Autor:
Joshua K. Stone, Natalia von Muhlinen, Chenran Zhang, Ana I. Robles, Amy L. Flis, Eleazar Vega-Valle, Akihiko Miyanaga, Masaru Matsumoto, K. Leigh Greathouse, Tomer Cooks, Giorgio Trinchieri, Curtis C. Harris
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-16 (2024)
Abstract Change within the intratumoral microbiome is a common feature in lung and other cancers and may influence inflammation and immunity in the tumor microenvironment, affecting growth and metastases. We previously characterized the lung cancer m
Externí odkaz:
https://doaj.org/article/cdfd8b5885b44df59ed98c80eee47052
Autor:
Ankan Choudhury, Patrick S. Ortiz, Mikaeel Young, Md. Toslim Mahmud, Ryan T. Stoffel, K. Leigh Greathouse, Christopher M. Kearney
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Helicobacter pylori is the primary cause of 78% of gastric cancer cases, providing an opportunity to prevent cancer by controlling a single bacterial pathogen within the complex gastric microbiota. We developed highly selective antimicrobial
Externí odkaz:
https://doaj.org/article/25e45f99e1eb47a7b416d19c12a04cb4
Autor:
K. Leigh Greathouse, Madhur Wyatt, Abigail J. Johnson, Eugene P. Toy, Joetta M. Khan, Kelly Dunn, Deborah J. Clegg, Sireesha Reddy
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 29, Iss , Pp 100800- (2022)
Dietary patterns contribute to cancer risk. Separately, microbial factors influence the development of several cancers. However, the interaction of diet and the microbiome and their joint contribution to cancer treatment response needs more research.
Externí odkaz:
https://doaj.org/article/18f8bfb902774687b8c4753a12eff193
Autor:
K. Leigh Greathouse, Ankan Choudhury
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 10, Pp 100430- (2021)
A recent study by Montalban-Arques et al.1 in Cell Host & Microbe shows that augmenting the function of the gut microbiota reduces tumor burden. Four Clostridiales species blocked tumor growth as efficient as chemotherapy or immunotherapy in colorect
Externí odkaz:
https://doaj.org/article/fa640d9aed1149718279d8ac12228282
Publikováno v:
JNCI: Journal of the National Cancer Institute.
Intratumoral microbes may have multifunctional roles in carcinogenesis. Microsatellite instability (MSI) is associated with higher tumor immunity and mutational burden. Using whole transcriptome and whole genome sequencing microbial abundance data, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::525820270cd0a73c7086578496034045
https://doi.org/10.1093/jnci/djad083
https://doi.org/10.1093/jnci/djad083
Publikováno v:
Microscopy.
Biological nanoparticles, such as bacterial outer membrane vesicles (OMVs), are routinely characterized through transmission electron microscopy (TEM). In this study, we report a novel method to prepare OMVs for TEM imaging. To preserve vesicular sha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b57593d98c0cfaaffb1637b9bc239c8c
https://doi.org/10.1093/jmicro/dfad027
https://doi.org/10.1093/jmicro/dfad027
Autor:
Bríd M. Ryan, Ann G. Schwartz, Bo Deng, Angela S. Wenzlaff, Susan Olivo-Marston, Yi Wang, K. Leigh Greathouse, Kirsi Vähäkangas, Elise D. Bowman, Kara Calhoun, Andrew C. McClary, Jin Jen, Ping Yang, Ana I. Robles
Main unadjusted effects of smoking, childhood and adult exposure to tobacco smoke and lung cancer risk.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df460653f90ea594be740072cfa0ae6
https://doi.org/10.1158/1940-6207.22524917.v1
https://doi.org/10.1158/1940-6207.22524917.v1
Autor:
Cheryl L. Walker, Shuk-mei Ho, Megan L. Mittelstadt, Kurunthachalam Kannan, Tia Berry, Kevin Lin, Jeffrey I. Everitt, Tiffany Bredfeldt, K. Leigh Greathouse
PDF file - 1.9MB, Effects of neonatal exposure to DES, GEN, or BPA (1, 50 or 50mg/kg, respectively for three consecutive days, PND 10-12) on adult uterine morphology. Shown are photomicrographs of hematoxylin and eosin-stained histological sections o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bf6aee8384a5553218d56b612300a2
https://doi.org/10.1158/1541-7786.22517398
https://doi.org/10.1158/1541-7786.22517398
Autor:
Bríd M. Ryan, Ann G. Schwartz, Bo Deng, Angela S. Wenzlaff, Susan Olivo-Marston, Yi Wang, K. Leigh Greathouse, Kirsi Vähäkangas, Elise D. Bowman, Kara Calhoun, Andrew C. McClary, Jin Jen, Ping Yang, Ana I. Robles
Lung cancer has a familial component which suggests a genetic contribution to its etiology. Given the strong evidence linking smoking with lung cancer, we studied miRNA-related loci in genes associated with smoking behavior. CHRNA, CHRNB gene familie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89fa8f3f8dc1a6b9b80aacc5a107c8fc
https://doi.org/10.1158/1940-6207.c.6544487
https://doi.org/10.1158/1940-6207.c.6544487