Zobrazeno 1 - 10
of 55
pro vyhledávání: '"K L Woolley"'
Publikováno v:
European Respiratory Journal. 9:2104-2108
The aims of this study were: to assess the safety of a sputum induction method using inhaled normal saline in children with acute asthma; and to investigate changes in sputum cell counts between acute exacerbations of asthma and its resolution. Ultra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f27bae97cca537a016c3ab12e03d5c
https://doi.org/10.1183/09031936.96.09102104
https://doi.org/10.1183/09031936.96.09102104
Autor:
Isao Ohno, Masaaki Honma, Kunio Shirato, Yuko Nitta, Kohei Yamauchi, Hiroki Hoshi, Paul M. O'Byrne, Gen Tamura, Manel Jordana, K L Woolley
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 15:404-409
The increase in thickness of bronchial walls by such structural changes as subepithelial fibrosis contributes to the severity and chronicity of asthma by amplifying airway narrowing. However, the pathogenesis of this structural alteration is not know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790cd6b3143d7595c9aa6d7a231654e4
https://doi.org/10.1165/ajrcmb.15.3.8810646
https://doi.org/10.1165/ajrcmb.15.3.8810646
Publikováno v:
Scopus-Elsevier
Asthma is accompanied by the accumulation of potentially damaging eosinophils within inflamed airways. How eosinophils may be removed from the airways is not clear. The phagocytic removal of eosinophils in vitro requires that they undergo apoptosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ca0fc2bd85aa3eb1158b3945c7602f
https://doi.org/10.1164/ajrccm.154.1.8680686
https://doi.org/10.1164/ajrccm.154.1.8680686
Autor:
Manel Jordana, I Ramis, Paul M. O'Byrne, E Adelroth, John S. Abrams, M. J. Woolley, K L Woolley
Publikováno v:
Scopus-Elsevier
Cytokines, such as interleukin-3 (IL-3), have been suggested to play an important role in mediating the increased number of airway eosinophils and metachromatic cells in patients with even mild asthma. We used immunohistochemistry to determine the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da3b7ed64362227f895d618e5fec997
https://doi.org/10.1164/ajrccm.153.1.8542142
https://doi.org/10.1164/ajrccm.153.1.8542142
Autor:
Paul M. O'Byrne, Masaaki Honma, Kohei Yamauchi, Yuko Nitta, K L Woolley, Hiroki Hoshi, Gen Tamura, Manel Jordana, Jerry Dolovich, Isao Ohno
Publikováno v:
Scopus-Elsevier
Tissue remodeling in bronchial tissues from asthmatics as well as in nasal polyp (NP) tissues includes sub-basement membrane deposition of collagen, stromal deposition of extracellular matrix protein, and hypertrophy/hyperplasia of airway smooth musc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a43777ffbf788fa678c259897f1218
https://doi.org/10.1165/ajrcmb.13.6.7576701
https://doi.org/10.1165/ajrcmb.13.6.7576701
Publikováno v:
Scopus-Elsevier
Allergen inhalation challenge is associated with increases in eosinophil number and activation, and provides a useful model for investigating airway inflammation in asthma. Limited information, however, is available on the effect of allergen challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ebfaf7ad75a00ce9bf176fe6507689
https://doi.org/10.1164/ajrccm.151.6.7767540
https://doi.org/10.1164/ajrccm.151.6.7767540
Publikováno v:
Scopus-Elsevier
Increasing evidence implicates the eosinophil as an important effector cell in asthma, but little is known regarding its regulation in vivo. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been shown to regulate eosinophil function in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84816334e807454f931a20a9358cd5d
https://doi.org/10.1183/09031936.94.07091576
https://doi.org/10.1183/09031936.94.07091576
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 149:1138-1141
Previous studies have suggested that the endogenous release of inhibitory prostanoids limits the bronchoconstrictor response to repeated exercise. The aim of our study was to determine whether inhaled prostaglandin (PG)E2 attenuates exercise-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a7bfb8926fac182be0acef65d35b4c
https://doi.org/10.1164/ajrccm.149.5.8173753
https://doi.org/10.1164/ajrccm.149.5.8173753
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 28(9)
Induced sputum is a useful way to monitor airway inflammation in asthma, but cell counts are time-consuming and labour intensive.The aim of this study was to evaluate a novel processing method using eosinophil cationic protein (ECP) as a biochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d95c0e7c7033e9d91b29b2d93455760
https://pubmed.ncbi.nlm.nih.gov/9761006
https://pubmed.ncbi.nlm.nih.gov/9761006
Autor:
M. J. Woolley, K L Woolley, Jennifer Wattie, C. G. Lane, Paul M. O'Byrne, M. Dahlback, W H Stevens, Russ Ellis
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 77(3)
The presence of airway eosinophils before allergen inhalation may contribute to the development of allergen-induced airway responses. We examined whether a reduction in airway eosinophil numbers before allergen inhalation as a result of inhalation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384edfe77ae4aef816f43d5fd49e7e3f
https://pubmed.ncbi.nlm.nih.gov/7836134
https://pubmed.ncbi.nlm.nih.gov/7836134