Zobrazeno 1 - 10
of 63
pro vyhledávání: '"K L Kaffka"'
Autor:
Patricia L. Kilian, Vincent S. Madison, Emily Labriola-Tompkins, M Hatada, J Karas, D Biondi, K L Kaffka, Grace Ju, Bradford Graves, C Chandran
Publikováno v:
Proceedings of the National Academy of Sciences. 88:11182-11186
Human interleukin 1 beta (IL-1 beta) exerts its diverse biological effects by binding to specific receptors on target cells. Two types of IL-1 receptor (IL-1R) have been identified: the type I IL-1R (p80) and the type II IL-1R (p68). Using site-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2154470c1d9859f2c01775964133906
https://doi.org/10.1073/pnas.88.24.11182
https://doi.org/10.1073/pnas.88.24.11182
Autor:
C A Campen, G J Stepan, K L Kaffka, William R. Benjamin, J M Plocinski, Patricia L. Kilian, Kim W. McIntyre, Richard Anthony Chizzonite, K D Kolinsky
Publikováno v:
The Journal of Experimental Medicine
Recombinant human interleukin 1 receptor antagonist (IL-1ra) and 35F5, a neutralizing monoclonal antibody (mAb) to the type I mouse IL-1 receptor, were examined for their ability to bind to IL-1 receptors (IL-1Rs) on various types of mouse cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333ca471d78384a1eb290f180418ac52
http://europepmc.org/articles/PMC2190808
http://europepmc.org/articles/PMC2190808
Publikováno v:
In Vitro Cellular & Developmental Biology. 26:1173-1179
Recent studies suggest that the proliferation and expression of HLA-DR molecules in endometrial epithelium may be regulated by systemic steroids and local cytokines. To test the interacting influences of cytokines and steroids on the expression of HL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3474810bad6e23f99bab8c558db2ced
https://doi.org/10.1007/bf02623695
https://doi.org/10.1007/bf02623695
Publikováno v:
Lymphokine and cytokine research. 11(2)
In this study murine splenocytes were found to possess specific, high-affinity IL-1 receptors (IL-1R) capable of binding radiolabeled human IL-1 alpha with a Kd of 2-6 x 10(-10) M. Experiments performed with purified splenic B cells demonstrated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eba80e1148dd7a98b25c03286bb4fcb3
https://pubmed.ncbi.nlm.nih.gov/1533794
https://pubmed.ncbi.nlm.nih.gov/1533794
Autor:
William R. Benjamin, S P Eisenberg, K L Kaffka, D Biondi, J M Plocinski, E Labriola-Tompkins, Grace Ju, Patricia L. Kilian, C A Campen, J Karas
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 88(7)
Interleukin 1 (IL-1) receptor antagonist (IL-1ra) is a naturally occurring protein that binds to the IL-1 receptor present on T cells, fibroblasts, and other cell types and acts to block IL-1-induced responses. IL-1ra is a pure antagonist and has no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2f2ec87383f17516729f452a64a055
https://pubmed.ncbi.nlm.nih.gov/1826365
https://pubmed.ncbi.nlm.nih.gov/1826365
Publikováno v:
Cancer research. 51(7)
The human ovarian carcinoma cell line, NIH:OVCAR-3, possesses high affinity receptors for interleukin-1 (IL-1). Binding experiments with 125I-IL-1 alpha indicate a dissociation constant of approximately 55 pM and the presence of approximately 7800 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::104eaa3e5d95c3f6e43de348ac0f2f2f
https://pubmed.ncbi.nlm.nih.gov/1825935
https://pubmed.ncbi.nlm.nih.gov/1825935
Publikováno v:
The Journal of clinical endocrinology and metabolism. 70(4)
Previous studies suggest that prostaglandin E2 (PGE2) is important in normal endometrial function and that it may be involved in certain uterine dysfunctions. In this study, the ability of the purified E. coli-derived recombinant interleukin-1 alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5198b53ee52332c29b606c3a9d48aeda
https://pubmed.ncbi.nlm.nih.gov/2138628
https://pubmed.ncbi.nlm.nih.gov/2138628
Autor:
W R, Benjamin, R A, Chizzonite, N S, Tare, J M, Plocinski, K L, Kaffka, K W, McIntyre, D A, Faherty, P L, Kilian
Publikováno v:
Progress in clinical and biological research. 349
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be4dfacdae0221eb0ebf694ed8e9716b
https://pubmed.ncbi.nlm.nih.gov/2144644
https://pubmed.ncbi.nlm.nih.gov/2144644
Autor:
P L Kilian, K L Kaffka, A S Stern, D Woehle, W R Benjamin, T M Dechiara, U Gubler, J J Farrar, S B Mizel, P T Lomedico
Publikováno v:
The Journal of Immunology. 136:4509-4514
Pure, E. coli-derived recombinant murine interleukin 1 alpha (IL 1 alpha) was labeled with 125I and used for receptor binding studies. The 125I-IL 1 binds to murine EL-4 thymoma cells in a specific and saturable manner. Scatchard plot analysis for bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4fb30e4bc104d33f0f452e7bcf72515
https://doi.org/10.4049/jimmunol.136.12.4509
https://doi.org/10.4049/jimmunol.136.12.4509
Autor:
Robert M. Crowl, R Bhatt, P L Kilian, K L Kaffka, L Collins, W H Tsien, Richard Anthony Chizzonite, Grace Ju
Publikováno v:
Journal of Biological Chemistry. 262:5723-5731
To locate functional domains of the interleukin-2 (IL-2) protein, a cDNA clone encoding biologically active human IL-2 was mutagenized using synthetic oligonucleotides to incorporate defined amino acid substitutions and deletions in the mature protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34c3ba0770f7c701f9f79be7f7f5490a
https://doi.org/10.1016/s0021-9258(18)45635-9
https://doi.org/10.1016/s0021-9258(18)45635-9