Výsledky vyhledávání

Solution structures of stromelysin complexed to thiadiazole inhibitors

Autor: David A. Kloosterman, L V Goodman, J.D Petke, G Vogeli, Vincent P. Marshall, B Mao, R. A. Poorman, D.J Waldon, S.A Mizsak, M. A. Mitchell, P S Kaytes, E.J Jacobsen, K L Belonga, G. L. Petzold, E.A Powers, Terrence A. Scahill, J.A Gates, S.R Ledbetter, Brian J. Stockman

Publikováno v: Scopus-Elsevier

Unregulated or overexpressed matrix metalloproteinases (MMPs), including stromelysin, collagenase, and gelatinase. have been implicated in several pathological conditions including arthritis and cancer. Small-molecule MMP inhibitors may have therapeu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32534366bba592aa46a204d7b6186be
https://doi.org/10.1002/pro.5560071105

Zobrazit plný text záznamu

3-Phenyl-Substituted Imidazo[1,5-a]quinoxalin-4-ones and Imidazo[1,5-a]quinoxaline Ureas That Have High Affinity at the GABAA/Benzodiazepine Receptor Complex

Autor: Wha Bin Im, Eric Jon Jacobsen, K. L. Belonga, Vimala H. Sethy, Donald B. Carter, J. D. Petke, L. S. Stelzer, Philip F. VonVoigtlander, Andrew H. Tang

Publikováno v: Journal of Medicinal Chemistry. 39:3820-3836

A series of imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas containing substituted phenyl groups at the 3-position was developed. Compounds within the imidazo[1,5-alpha]quinoxaline urea series had high affinity for the GAB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54362f2ab2566324930ba2cdede281ed
https://doi.org/10.1021/jm960070+

Zobrazit plný text záznamu

High-Affinity Partial Agonist Imidazo[1,5-a]quinoxaline Amides, Carbamates, and Ureas at the γ-Aminobutyric Acid A/Benzodiazepine Receptor Complex

Autor: J. D. Petke, L. S. Stelzer, Donald B. Carter, Philip F. VonVoigtlander, Tenbrink Ruth E, H. K. Im, Vimala H. Sethy, Eric Jon Jacobsen, Wha Bin Im, Andrew H. Tang, K. L. Belonga

Publikováno v: Journal of Medicinal Chemistry. 39:158-175

A series of imidazo[1,5-a]quinoxaline amides, carbamates, and ureas which have high affinity for the gamma-aminobutyric acid A/benzodiazepine receptor complex was developed. Compounds within this class have varying efficacies ranging from antagonists

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5414df68ea1c5ffa659277bcc6b94528
https://doi.org/10.1021/jm940765f

Zobrazit plný text záznamu

2-(Aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia

Autor: Eric Jon Jacobsen, K. L. Belonga, VanDoornik Fj, David J. Houser, Braughler Jm, Edward D. Hall, Donald E. Ayer

Publikováno v: Journal of Medicinal Chemistry. 35:4464-4472

A series of 2-(aminomethyl)chromans was developed as potent inhibitors of iron-dependent lipid peroxidation. Compounds within this class are extremely effective at inhibiting lipid peroxidation with IC50's as low as 0.2 microM. Selected members were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45a7d58fd342d956d75c9f0e2e2362a
https://doi.org/10.1021/jm00101a025

Zobrazit plný text záznamu

Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants

Autor: E D, Hall, P K, Andrus, S L, Smith, J A, Oostveen, H M, Scherch, B S, Lutzke, T J, Raub, G A, Sawada, J R, Palmer, L S, Banitt, J S, Tustin, K L, Belonga, D E, Ayer, G L, Bundy

Publikováno v: Acta neurochirurgica. Supplement. 66

The 21-aminosteroid (lazaroid) tirilazad mesylate has been demonstrated to be a potent inhibitor of lipid peroxidation and to reduce traumatic and ischemic damage in a number of experimental models. Currently, tirilazad is being actively investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef2a22bfa5202feee4c71d54b7000ffa
https://pubmed.ncbi.nlm.nih.gov/8780807

Zobrazit plný text záznamu

Neuroprotective Efficacy of Microvascularly-Localized Versus Brain-Penetrating Antioxidants

Autor: Gordon L. Bundy, Geri A. Sawada, Paula K. Andrus, Sarah L. Smith, J. S. Tustin, John R. Palmer, Edward D. Hall, Donald E. Ayer, Thomas J. Raub, Barry S. Lutzke, Jo A. Oostveen, Heidi M. Scherch, K. L. Belonga, L. S. Banitt

Publikováno v: Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma ISBN: 9783709194676

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8124d77933406848f8de36a79d00aa7
https://doi.org/10.1007/978-3-7091-9465-2_19

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání