Výsledky vyhledávání - "K L, Whitcomb"

Autor: A G Paige, J Liu, O Kinstler, K L Whitcomb

Publikováno v: Pharmaceutical Research. 12:1883-1888

Purpose. Recombinant human granulocyte-colony stimulating factor (rhG-CSF) was covalently conjugated to both rat and human serum albumin (RSA and HSA respectively) to increases the circulating half life (t1/2) of rhG-CSF.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ffc4a966e7e47f62813a58f536b2956
https://doi.org/10.1023/a:1016227519561

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Autor: R W Niven, A Y Ip, K L Whitcomb, L Shaner, O B Kinstler

Publikováno v: Pharmaceutical Research. 12:1343-1349

Purpose. The objective of this study was to highlight differences in the pulmonary absorption of a monoPEGylated rhG-CSF and rhG-CSF after intratracheal instillation and aerosol delivery.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e48dd694c02af00c981f8d3b9408d11
https://doi.org/10.1023/a:1016281925554

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Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality

Autor: C L, Farrell, J V, Bready, K L, Rex, J N, Chen, C R, DiPalma, K L, Whitcomb, S, Yin, D C, Hill, B, Wiemann, C O, Starnes, A M, Havill, Z N, Lu, S L, Aukerman, G F, Pierce, A, Thomason, C S, Potten, T R, Ulich, D L, Lacey

Publikováno v: Cancer research. 58(5)

Keratinocyte growth factor (KGF) stimulates the proliferation and differentiation of epithelial cells including those of the gastrointestinal tract. Although chemotherapeutics and radiation exposure kill rapidly proliferating tumor cells, rapidly div

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c7d8168e7e876dd5ddafd43d6336397
https://pubmed.ncbi.nlm.nih.gov/9500453

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Systemic absorption and activity of recombinant consensus interferons after intratracheal instillation and aerosol administration

Autor: R W, Niven, K L, Whitcomb, M, Woodward, J, Liu, C, Jornacion

Publikováno v: Pharmaceutical research. 12(12)

The pulmonary pharmacokinetics and bioactivity of E. coli derived recombinant consensus interferon (CIFN) and a modified lactose-conjugated consensus interferon (LacCIFN) were evaluated in animals.Estimated doses of 20 and 100 micrograms/kg of the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b1caea60f2da5b69098e14e5ad15099
https://pubmed.ncbi.nlm.nih.gov/8786962

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Prolonged circulation of recombinant human granulocyte-colony stimulating factor by covalent linkage to albumin through a heterobifunctional polyethylene glycol

Autor: A G, Paige, K L, Whitcomb, J, Liu, O, Kinstler

Publikováno v: Pharmaceutical research. 12(12)

Recombinant human granulocyte-colony stimulating factor (rhG-CSF) was covalently conjugated to both rat and human serum albumin (RSA and HSA respectively) to increases the circulating half life (t1/2) of rhG-CSF.Conjugates of RSA (MW 67,000) and HSA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95231491b82d0a5c1bae7bee7b57608f
https://pubmed.ncbi.nlm.nih.gov/8786961

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The pulmonary absorption of aerosolized and intratracheally instilled rhG-CSF and monoPEGylated rhG-CSF

Autor: R W, Niven, K L, Whitcomb, L, Shaner, A Y, Ip, O B, Kinstler

Publikováno v: Pharmaceutical research. 12(9)

The objective of this study was to highlight differences in the pulmonary absorption of a monoPEGylated rhG-CSF and rhG-CSF after intratracheal instillation and aerosol delivery.Male Sprague Dawley rats (250 g) were anesthetized and intratracheally i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3bfddd1749fcde7d9f953f9d617b05c0
https://pubmed.ncbi.nlm.nih.gov/8570533

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