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pro vyhledávání: '"K L, Tivel"'
Publikováno v:
Molecular pharmacology. 50(4)
Multiple drug resistance (MDR) as a result of overexpression of the P-glycoprotein drug transporter, a product of the MDR1 gene, is a significant problem in cancer therapeutics. We demonstrate that phosphorothioate antisense oligonucleotides can redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71d4a43c0023251b9d9aa3a4ab91085a
https://pubmed.ncbi.nlm.nih.gov/8863825
https://pubmed.ncbi.nlm.nih.gov/8863825
Autor:
S T, Crooke, M J, Graham, J E, Zuckerman, D, Brooks, B S, Conklin, L L, Cummins, M J, Greig, C J, Guinosso, D, Kornbrust, M, Manoharan, H M, Sasmor, T, Schleich, K L, Tivel, R H, Griffey
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(2)
Biophysical and pharmacokinetic properties of five analogs of ISIS 3082, a 20-mer phosphorothioate oligodeoxynucleotide that inhibits the expression of mouse intercellular adhesion molecule 1, were evaluated. Compared to the parent compound, ISIS 308
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d2defa0c01a053d57855b82849fe768
https://pubmed.ncbi.nlm.nih.gov/8627575
https://pubmed.ncbi.nlm.nih.gov/8627575