Zobrazeno 1 - 10
of 21
pro vyhledávání: '"K L, Lunetta"'
Autor:
J E Siland, B Geelhoed, C Roselli, B Wang, H J Lin, S Weiss, S Trompet, M E van den Berg, E Z Soliman, L Y Chen, I Ford, J W Jukema, P W Macfarlane, J Kornej, H Lin, K L Lunetta, M Kavousi, J A Kors, M A Ikram, X Guo, J Yao, M Dörr, S B Felix, U Völker, N Sotoodehnia, D E Arking, B H Stricker, S R Heckbert, S A Lubitz, E J Benjamin, A Alonso, P T Ellinor, P van der Harst, M Rienstra
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268768 (2022)
BackgroundBoth elevated and low resting heart rates are associated with atrial fibrillation (AF), suggesting a U-shaped relationship. However, evidence for a U-shaped causal association between genetically-determined resting heart rate and incident A
Externí odkaz:
https://doaj.org/article/ac9d5b0f7c084fa48d7e8ef72647886a
Autor:
Jirong Long, Nora Franceschini, Charles Kooperberg, Eric Boerwinkle, Julie R. Palmer, Laura M. Raffield, Guochong Jia, Lindsay Fernández-Rhodes, Wei Zheng, K. L. Lunetta, Tamar Sofer, Robert B. Wallace, Diana L. Cousminer, Quenna Wong, Joanne M. Murabito, Leslie A. Lange, Babette S. Zemel, Struan F.A. Grant, Ran Tao, Chloé Sarnowski, Jonathan P. Bradfield, Gary Zirpoli, Kari E. North, Hakon Hakonarson, Adolfo Correa
Publikováno v:
Hum Reprod
STUDY QUESTIONDoes the expansion of genome-wide association studies (GWAS) to a broader range of ancestries improve the ability to identify and generalise variants associated with age at menarche (AAM) in European populations to a wider range of worl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0877b9c4d62e3355c3705ca67e7a9426
https://pubmed.ncbi.nlm.nih.gov/34021356
https://pubmed.ncbi.nlm.nih.gov/34021356
Autor:
Schellenberg Gd, Haines Jl, K. L. Lunetta, Lindsay A. Farrer, Gaoyuan Meng, Yang You, Jaeyoon Chung, Tatiana Foroud, Richard Mayeux, Tsuneya Ikezu, David A. Bennett, Li-San Wang, Rhoda Au, Margaret A. Pericak-Vance, Junming Hu, Congcong Zhu, Rebecca Panitch, Weiming Xia, Gyungah Jun, Thor D. Stein
BackgroundRecent reports suggest that the rare apolipoprotein E (APOE) Christchurch mutation and ε2 allele protect against Alzheimer’s disease (AD) pathology by reducing the burden of tau pathology. However, the mechanism(s) underlying the ε2 pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12271ba8174512e10930dd6cef81dc0c
https://doi.org/10.1101/2020.11.20.20235051
https://doi.org/10.1101/2020.11.20.20235051
Autor:
Johan G. Eriksson, Ayse Demirkan, Francesco Cucca, Hanna Ollila, Klaus Berger, A.G. Uitterlinden, Sharon L.R. Kardia, Yongmei Liu, Veikko Salomaa, W. V. Zhuang, Antonio Terracciano, Nese Direk, Osorio Meirelles, K. L. Lunetta, Myriam Fornage, Jennifer A. Smith, Lei Yu, Karin Hek, Aarno Palotie, Elisabeth Widen, Karestan C. Koenen, Thomas H. Mosley, Jürgen Wellmann, Markus Perola, Wei Zhao, Luigi Ferrucci, Kristine Yaffe, C M van Duijn, A. Hofman, Angelina R. Sutin, Aaron Isaacs, Jessica D. Faul, Paul Lichtenstein, Mike A. Nalls, Patrik K. E. Magnusson, Ben A. Oostra, Alexander Viktorin, Anna Murray, Jari Lahti, Mikael Landén, Joanne M. Murabito, David R. Weir, Toshiko Tanaka, Nancy L. Pedersen, Jun Ding, Luke C. Pilling, David A. Bennett, Tiina Paunio, Alan B. Zonderman, Marilyn C. Cornelis, Fernando Rivadeneira, David J. Llewellyn, Henning Tiemeier, Katri Räikkönen, Annemarie I. Luik, Antonella Mulas, Tamara B. Harris
Publikováno v:
Psychological Medicine, 46(8), 1613-1623. Cambridge University Press
BackgroundMajor depressive disorder (MDD) is moderately heritable, however genome-wide association studies (GWAS) for MDD, as well as for related continuous outcomes, have not shown consistent results. Attempts to elucidate the genetic basis of MDD m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928a41c5b883998a79f85f0291c8e8a8
https://doi.org/10.1017/s0033291715002081
https://doi.org/10.1017/s0033291715002081
Autor:
K. L. Lunetta, Shalender Bhasin, David Karasik, Douglas P. Kiel, Wei V. Zhuang, Thomas G. Travison, Joanne M. Murabito, Andrea D. Coviello
Publikováno v:
Clinical Endocrinology. 80:277-282
SummaryObjective Circulating testosterone, oestradiol and oestrone concentrations vary considerably between men. Although a substantial proportion of this variation may be attributed to morbidity and behavioural factors, these cannot account for its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fc03843903638eb25c8a32a3aecc7a9
https://doi.org/10.1111/cen.12260
https://doi.org/10.1111/cen.12260
Autor:
K. L. Lunetta, C.M. van Duijn, A.G. Uitterlinden, Stefania Bandinelli, Linda Broer, A. M. Arnold, Yongmei Liu, Marcus Dörr, Joanne M. Murabito, W. Hoffmann, Toshiko Tanaka, Thomas Kocher, Albert Hofman, Ellen W. Demerath, Albert V. Smith, Jerome I. Rotter, David Karasik, Bruce M. Psaty, Vilmundur Gudnason, Robert C. Kaplan, Ben A. Oostra, Kurt Lohman, Lenore J. Launer, G. J. Tranah, Luigi Ferrucci, S. Walter, H. Wallaschofski, M. E. Garcia, Nora Franceschini, Henning Tiemeier, Tamara B. Harris, Douglas P. Kiel, Gil Atzmon, G. Homuth, A.B. Newman
Publikováno v:
Age, 35(4), 1367-1376. Springer International Publishing AG
Age
Age
Experimental mild heat shock is widely known as an intervention that results in extended longevity in various models along the evolutionary lineage. Heat shock proteins (HSPs) are highly upregulated immediately after a heat shock. The elevation in HS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f233bed3aefd977f9ee2673787b71313
https://doi.org/10.1007/s11357-012-9417-7
https://doi.org/10.1007/s11357-012-9417-7
Autor:
Richard C. Green, Mark W. Logue, Charles DeCarli, Holly Posner, Heng Zou, Stephen W. Hurt, L. Adrienne Cupples, Lindsay A. Farrer, Margaret Moline, K. L. Lunetta
Publikováno v:
Alzheimer's & Dementia. 7:493-500
Background Recent pathological studies report vascular pathology in clinically diagnosed Alzheimer's disease (AD) and AD pathology in clinically diagnosed vascular dementia (VaD). We compared magnetic resonance imaging (MRI) measures of vascular brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f6f571a4e3dd19c9945f78ea179fc67
https://doi.org/10.1016/j.jalz.2011.01.004
https://doi.org/10.1016/j.jalz.2011.01.004
Autor:
L. A. Cupples, K. L. Lunetta, Robert C. Green, Stefan Wagenpfeil, Charles DeCarli, Robert Perneczky, Lindsay A. Farrer, Alexander Kurz
Publikováno v:
Neurology. 75:137-142
Background: Clinical and epidemiologic studies suggest that patients with Alzheimer disease (AD) with larger head circumference have better cognitive performance at the same level of brain pathology than subjects with smaller head circumference.Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ababf60740497c9491bdd375ba800b5c
https://doi.org/10.1212/wnl.0b013e3181e7ca97
https://doi.org/10.1212/wnl.0b013e3181e7ca97
Publikováno v:
Human Heredity. 59:125-135
The Haplotype Relative Risk (HRR) was first proposed [Falk et al., Ann Hum Genet 1987] to test for Linkage Disequilibrium (LD) between a marker and a putative disease locus using case-parent trios. Spurious association does not appear in such family-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360d798a9708eff1b774dc48d9b2f606
https://doi.org/10.1159/000085571
https://doi.org/10.1159/000085571
Publikováno v:
GeneScreen. 1:41-45
Introduction Genotyping of a set of microsatellite markers is often necessary to map genes for complex human diseases by linkage analysis. Presence of null alleles (such as a mutation in the primer-binding sequence) can lead to pseudo-deficiency of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d69fcdecf9588d936a5a4157125fb06c
https://doi.org/10.1046/j.1466-9218.2000.00007.x
https://doi.org/10.1046/j.1466-9218.2000.00007.x