Zobrazeno 1 - 10
of 48
pro vyhledávání: '"K L, Kunze"'
Autor:
P. L. S. Uson, K. L. Kunze, M. A. Golafshar, G. Botrus, D. Riegert-Johnson, L. Boardman, M. J. Borad, D. Ahn, M. B. Sonbol, A. Kahn, M. Klint, E. D. Esplin, R. L. Nussbaum, A. K. Stewart, T. Bekaii-Saab, N. J. Samadder
Publikováno v:
Digestive Diseases and Sciences. 67:5107-5115
To determine prevalence and clinical utility of pathogenic germline variants (PGV) in gastric and esophageal cancer patients using universal genetic testing approach.We undertook a prospective study of germline sequencing using an 80 gene next-genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b2e553962a4145aaf3c8e32ea72fd8
https://doi.org/10.1007/s10620-022-07387-x
https://doi.org/10.1007/s10620-022-07387-x
Publikováno v:
Pharmaceutical research. 17(3)
The intestinal metabolism of some CYP3A substrates can be altered profoundly by co-administration of the potent inhibitor, ketoconazole. The present research was conducted to test the hypothesis that, unlike the inhibition kinetics observed with isol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ef793fa40b39e2b4821ed335bfdb770
https://pubmed.ncbi.nlm.nih.gov/10801218
https://pubmed.ncbi.nlm.nih.gov/10801218
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(5)
The purpose of this work was to evaluate the effect of mutual unbound inhibitor and unbound enzyme depletion on the potency of three antifungal cytochrome P-450 (CYP)3A inhibitors with over 1000-fold range in enzyme affinity. Incubations were perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6aff131baed2dad473aa39bded9c9df5
https://pubmed.ncbi.nlm.nih.gov/10220488
https://pubmed.ncbi.nlm.nih.gov/10220488
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
It has been suggested that the binding of a drug to plasma proteins will influence the intestinal extraction efficiency when drug is delivered to the mucosal epithelium via either the gut lumen or vasculature. We evaluated this hypothesis using cytoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fabd6479349bbcc04e20255b7a97aa86
https://pubmed.ncbi.nlm.nih.gov/10215698
https://pubmed.ncbi.nlm.nih.gov/10215698
Autor:
J M, Fisher, S A, Wrighton, P B, Watkins, P, Schmiedlin-Ren, J C, Calamia, D D, Shen, K L, Kunze, K E, Thummel
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
Cytochrome P-450 (CYP) 3A4 accounts for approximately 50% of all P-450s found in the small intestine (Paine et al., 1997) and contributes to the extensive and variable first-pass extraction of drugs such as cyclosporine and saquinavir. We recently de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6789775d613f0dd7610a3a8071ef759
https://pubmed.ncbi.nlm.nih.gov/10215697
https://pubmed.ncbi.nlm.nih.gov/10215697
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(2)
The purpose of this study was to compare the kinetics of intestinal and hepatic cytochrome P-450 3A (CYP3A) inhibition by using microsomal midazolam 1'-hydroxylation as a marker of enzyme activity. The effect of two antifungal agents commonly implica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0a69f14e51ce48d7d3f2bfd8a6ee15c
https://pubmed.ncbi.nlm.nih.gov/9929500
https://pubmed.ncbi.nlm.nih.gov/9929500
Publikováno v:
Anesthesiology. 87(1)
There is considerable unexplained variability in alfentanil pharmacokinetics, particularly systemic clearance. Alfentanil is extensively metabolized in vivo, and thus systemic clearance depends on hepatic biotransformation. Cytochrome P450 3A4 was pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d276e68ffa5e4a058cc311c39501468d
https://pubmed.ncbi.nlm.nih.gov/9232132
https://pubmed.ncbi.nlm.nih.gov/9232132
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(5)
Kinetic studies demonstrate that two forms of human liver cytochrome P450 are responsible for the formation of (R)-8-hydroxywarfarin: a low-affinity enzyme (KM approximately 1.5 mM), previously identified as P4501A2; and a high-affinity enzyme (KM =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33dbf88a6c27aba01e93d34288e7c3fc
https://pubmed.ncbi.nlm.nih.gov/8723744
https://pubmed.ncbi.nlm.nih.gov/8723744
Autor:
D J, Black, K L, Kunze, L C, Wienkers, B E, Gidal, T L, Seaton, N D, McDonnell, J S, Evans, J E, Bauwens, W F, Trager
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(4)
Consistent with expectations based on human in vitro microsomal experiments, administration of fluconazole (400 mg/day) for 6 days to six human volunteers significantly reduced the cytochrome P450 (P450)-dependent metabolic clearance of the warfarin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4856d1d501c512806cba1d22e667419
https://pubmed.ncbi.nlm.nih.gov/8801057
https://pubmed.ncbi.nlm.nih.gov/8801057
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(4)
The antifungal agent fluconazole was found to be a potent inhibitor of cytochrome P450 (P450) 2C9 (Ki = 7-8 microM), the principal enzyme responsible for the clearance (85%) of the more potent anticoagulant (S)-warfarin to the inactive (S)-7- and (S)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1afd5bfe9868126e0065c1132184ae68
https://pubmed.ncbi.nlm.nih.gov/8801056
https://pubmed.ncbi.nlm.nih.gov/8801056