Zobrazeno 1 - 10
of 19
pro vyhledávání: '"K L, Hadingham"'
Publikováno v:
Journal of Neurochemistry. 66:1318-1321
We studied whether microtubule organization is important for actions of ethanol on GABAA ergic responses by testing the effects of microtubule depolymerization on ethanol enhancement of GABA action in mouse L(tk-) cells stably transfected with GABAA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceabbf0d5677203545bba6db383fb248
https://doi.org/10.1046/j.1471-4159.1996.66031318.x
https://doi.org/10.1046/j.1471-4159.1996.66031318.x
Autor:
Paul J. Whiting, M. Anna Casula, Peter B. Wingrove, Frances A. Bromidge, Karen A. Maubach, Karine Martin, Guy R. Seabrook, K. L. Hadingham, Gopalan V. Pillai
Publikováno v:
Journal of Neurochemistry. 77:445-451
L-655,708 is a ligand for the benzodiazepine site of the γ-aminobutyric acid type A (GABAA) receptor that exhibits a 100-fold higher affinity for α5-containing receptors compared with α1-containing receptors. Molecular biology approaches have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5ef9a56887f09ac75c9459e9ec8ec96
https://doi.org/10.1046/j.1471-4159.2001.00289.x
https://doi.org/10.1046/j.1471-4159.2001.00289.x
Publikováno v:
British Journal of Pharmacology. 108:711-716
1. Whole-cell patch clamp recordings were made from L-cells transfected with 2 combinations of subunits of the GABAA receptor. Log concentration-response curves were constructed to gamma-aminobutyric acid (GABA) on alpha 1,beta 1,gamma 2L containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b0a46f5ecc238450fdbdff3d038024
https://doi.org/10.1111/j.1476-5381.1993.tb12866.x
https://doi.org/10.1111/j.1476-5381.1993.tb12866.x
Autor:
K Quirk, C I Ragan, Eric A. Barnard, P C Harkness, Paul J. Whiting, B. Le Bourdelles, Ruth M. McKernan, K. L. Hadingham, A. L. Horne, John A. Kemp
Publikováno v:
Proceedings of the National Academy of Sciences. 89:6378-6382
The differential sensitivity of type A gamma-aminobutyric acid (GABAA) receptors to benzodiazepine ligands seen in the mammalian nervous system is thought to be generated by the existence of a number of different receptor subtypes, assembled from a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f474aa3ff5906690d76a930a1bb3190e
https://doi.org/10.1073/pnas.89.14.6378
https://doi.org/10.1073/pnas.89.14.6378
Autor:
Shil Patel, George McAllister, Josephine A. Stanton, Andrew Pate Owens, Paul J. Whiting, Martin R. Guscott, Kevin C. F. Fone, Stephany M. Biello, J Myers, Margaret S. Beer, K. L. Hadingham, Janusz Jozef Kulagowski, Frances A. Bromidge, Peter H. Hutson, Ian Thomas Huscroft, Thomas W. Rosahl, Nadia Melanie Rupniak, Linda J. Bristow
Publikováno v:
Neuropharmacology. 48(4)
The affinity of several antidepressant and antipsychotic drugs for the 5-HT7 receptor and its CNS distribution suggest potential in the treatment of psychiatric diseases. However, there is little direct evidence of receptor function in vivo to suppor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5ce4c2820c481661443d18cc05cd26
https://pubmed.ncbi.nlm.nih.gov/15755477
https://pubmed.ncbi.nlm.nih.gov/15755477
Autor:
Cyrille Sur, J Myers, Alison J. Macaulay, Peter H. Hutson, Jeremy J. Lambert, John R. Atack, Alison R. Haythornthwaite, Ruth M. McKernan, Richard J. Newman, K. L. Hadingham, Owain W. Howell, Keith A. Wafford, Jennifer Cirone, Gerard R. Dawson, Gillian F. O'Meara, Delia Belelli, David S. Reynolds, Paul J. Whiting, Thomas W. Rosahl, A. Richard Rutter
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(24)
The specific mechanisms underlying general anesthesia are primarily unknown. The intravenous general anesthetic etomidate acts by potentiating GABAAreceptors, with selectivity for β2 and β3 subunit-containing receptors determined by a single aspara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b636265f70a6ef4f5984c13459c1e0b4
https://pubmed.ncbi.nlm.nih.gov/13679430
https://pubmed.ncbi.nlm.nih.gov/13679430
Autor:
Neil Collinson, Cyrille Sur, John R. Atack, Richard J. Newman, Alison J. Macaulay, Gillian F. O'Meara, Owain W. Howell, David S. Reynolds, Frances A. Bromidge, Keith A. Wafford, Ruth M. McKernan, K. L. Hadingham, Paul J. Whiting, Thomas W. Rosahl, Gerard R. Dawson, J Myers
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(10)
The alpha1beta2gamma2 is the most abundant subtype of the GABA(A) receptor and is localized in many regions of the brain. To gain more insight into the role of this receptor subtype in the modulation of inhibitory neurotransmission, we generated mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298f8379784aa0a5d23b087d4be47a56
https://pubmed.ncbi.nlm.nih.gov/11331371
https://pubmed.ncbi.nlm.nih.gov/11331371
Autor:
M A, Casula, F A, Bromidge, G V, Pillai, P B, Wingrove, K, Martin, K, Maubach, G R, Seabrook, P J, Whiting, K L, Hadingham
Publikováno v:
Journal of neurochemistry. 77(2)
L-655,708 is a ligand for the benzodiazepine site of the gamma-aminobutyric acid type A (GABA(A)) receptor that exhibits a 100-fold higher affinity for alpha5-containing receptors compared with alpha1-containing receptors. Molecular biology approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d5f8d184381093ad80e25fc849fab2a
https://pubmed.ncbi.nlm.nih.gov/11299307
https://pubmed.ncbi.nlm.nih.gov/11299307
Autor:
Anthony J. Woollacott, Guy R. Seabrook, Gopalan V. Pillai, Peter B. Simpson, Hedaythul Choudhury, Karen A. Maubach, K. L. Hadingham, Karine Martin
Publikováno v:
Journal of neuroscience methods. 99(1-2)
To facilitate the discovery of novel compounds that modulate human GABA(A) receptor function, we have developed a high throughput functional assay using a fluorescence imaging system. L(tk-) cells expressing combinations of human GABA(A) receptor sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40ebc3954b988899f4490c4b9dbbe40
https://pubmed.ncbi.nlm.nih.gov/10936648
https://pubmed.ncbi.nlm.nih.gov/10936648
Autor:
S.M. O'Shea, Neil L. Harrison, Matthew D. Krasowski, Caroline E. Rick, Cynthia Czajkowski, K. L. Hadingham, Paul J. Whiting
We have investigated the role of the alpha subunit in the modulation of gamma-aminobutyric acid type A (GABA(A)) receptors by the general anesthetic propofol, using whole-cell patch clamp recordings made from distinct stable fibroblast cell lines whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c223ed1023e049a15af6a7fc354f76
https://europepmc.org/articles/PMC2857729/
https://europepmc.org/articles/PMC2857729/
