Zobrazeno 1 - 10
of 10
pro vyhledávání: '"K L, Belonga"'
Autor:
David A. Kloosterman, L V Goodman, J.D Petke, G Vogeli, Vincent P. Marshall, B Mao, R. A. Poorman, D.J Waldon, S.A Mizsak, M. A. Mitchell, P S Kaytes, E.J Jacobsen, K L Belonga, G. L. Petzold, E.A Powers, Terrence A. Scahill, J.A Gates, S.R Ledbetter, Brian J. Stockman
Publikováno v:
Scopus-Elsevier
Unregulated or overexpressed matrix metalloproteinases (MMPs), including stromelysin, collagenase, and gelatinase. have been implicated in several pathological conditions including arthritis and cancer. Small-molecule MMP inhibitors may have therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32534366bba592aa46a204d7b6186be
https://doi.org/10.1002/pro.5560071105
https://doi.org/10.1002/pro.5560071105
Autor:
Wha Bin Im, Eric Jon Jacobsen, K. L. Belonga, Vimala H. Sethy, Donald B. Carter, J. D. Petke, L. S. Stelzer, Philip F. VonVoigtlander, Andrew H. Tang
Publikováno v:
Journal of Medicinal Chemistry. 39:3820-3836
A series of imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas containing substituted phenyl groups at the 3-position was developed. Compounds within the imidazo[1,5-alpha]quinoxaline urea series had high affinity for the GAB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54362f2ab2566324930ba2cdede281ed
https://doi.org/10.1021/jm960070+
https://doi.org/10.1021/jm960070+
Publikováno v:
The Journal of Organic Chemistry. 60:4177-4183
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6efd078763db9e715543f10879830eb
https://doi.org/10.1021/jo00118a039
https://doi.org/10.1021/jo00118a039
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd4b63f9b99b0a65b9c62e2a022bdd3
https://doi.org/10.1002/chin.199546187
https://doi.org/10.1002/chin.199546187
Autor:
G. E. Padbury, P. G. Larson, C. S. Aaron, L. S. Banitt, K. L. Linseman, J. K. Mayo, J. E. Chin, P. A. Yonkers, Heidi M. Scherch, E. D. Hall, Stephen A. Mizsak, K. L. Belonga, Gordon L. Bundy, J. M. Lin, F. F. Sun, J. M. Tustin, I. M. Richards, Donald E. Ayer, John R. Palmer
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53e41174a634527607b1c5c03a355d49
https://doi.org/10.1002/chin.199607175
https://doi.org/10.1002/chin.199607175
Autor:
Eric Jon Jacobsen, K. L. Belonga, VanDoornik Fj, David J. Houser, Braughler Jm, Edward D. Hall, Donald E. Ayer
Publikováno v:
Journal of Medicinal Chemistry. 35:4464-4472
A series of 2-(aminomethyl)chromans was developed as potent inhibitors of iron-dependent lipid peroxidation. Compounds within this class are extremely effective at inhibiting lipid peroxidation with IC50's as low as 0.2 microM. Selected members were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45a7d58fd342d956d75c9f0e2e2362a
https://doi.org/10.1021/jm00101a025
https://doi.org/10.1021/jm00101a025
Autor:
E D, Hall, P K, Andrus, S L, Smith, J A, Oostveen, H M, Scherch, B S, Lutzke, T J, Raub, G A, Sawada, J R, Palmer, L S, Banitt, J S, Tustin, K L, Belonga, D E, Ayer, G L, Bundy
Publikováno v:
Acta neurochirurgica. Supplement. 66
The 21-aminosteroid (lazaroid) tirilazad mesylate has been demonstrated to be a potent inhibitor of lipid peroxidation and to reduce traumatic and ischemic damage in a number of experimental models. Currently, tirilazad is being actively investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef2a22bfa5202feee4c71d54b7000ffa
https://pubmed.ncbi.nlm.nih.gov/8780807
https://pubmed.ncbi.nlm.nih.gov/8780807
Autor:
Gordon L. Bundy, Geri A. Sawada, Paula K. Andrus, Sarah L. Smith, J. S. Tustin, John R. Palmer, Edward D. Hall, Donald E. Ayer, Thomas J. Raub, Barry S. Lutzke, Jo A. Oostveen, Heidi M. Scherch, K. L. Belonga, L. S. Banitt
Publikováno v:
Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma ISBN: 9783709194676
The 21-aminosteroid (lazaroid) tirilazad mesylate has been demonstrated to be a potent inhibitor of lipid peroxidation and to reduce traumatic and ischemic damage in a number of experimental models. Currently, tirilazad is being actively investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8124d77933406848f8de36a79d00aa7
https://doi.org/10.1007/978-3-7091-9465-2_19
https://doi.org/10.1007/978-3-7091-9465-2_19
Autor:
J. E. Chin, Donald E. Ayer, Gordon L. Bundy, K. L. Belonga, Edward D. Hall, L. S. Banitt, K. L. Linseman, S A Mizsak, J. M. Tustin, John R. Palmer
Publikováno v:
Journal of medicinal chemistry. 38(21)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7b385a200d07d19f00cb82d7c43d4e
https://pubmed.ncbi.nlm.nih.gov/7473542
https://pubmed.ncbi.nlm.nih.gov/7473542
Autor:
E J, Jacobsen, J M, McCall, D E, Ayer, F J, Van Doornik, J R, Palmer, K L, Belonga, J M, Braughler, E D, Hall, D J, Houser, M A, Krook
Publikováno v:
Journal of medicinal chemistry. 33(4)
A novel class of 21-aminosteroids has been developed. Compounds within this series are potent inhibitors of iron-dependent lipid peroxidation in rat brain homogenates with IC50's as low as 3 microM. Furthermore, selected members enhance early neurolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e58ba70111a269922c928458ad3f70f
https://pubmed.ncbi.nlm.nih.gov/2319560
https://pubmed.ncbi.nlm.nih.gov/2319560