Zobrazeno 1 - 10
of 393
pro vyhledávání: '"K Kumasaka"'
ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models
Autor:
Sebastian Schmid, Zachary R. Russell, Alex Shimura Yamashita, Madeline E. West, Abigail G. Parrish, Julia Walker, Dmytro Rudoy, James Z. Yan, David C. Quist, Betemariyam N. Gessesse, Neriah Alvinez, Kimberly D. Hill, Larry W. Anderson, Patrick J. Cimino, Debra K. Kumasaka, Ralph E. Parchment, Eric C. Holland, Frank Szulzewsky
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114829- (2024)
Summary: Pediatric-type high-grade gliomas frequently harbor gene fusions involving receptor tyrosine kinase genes, including neurotrophic tyrosine kinase receptor (NTRK) fusions. Clinically, these tumors show high initial response rates to tyrosine
Externí odkaz:
https://doaj.org/article/4470af9805e444e2b122261c594c9aa1
Akademický článek
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Autor:
Anupam Jhingran, Katrina B. Mar, Debra K. Kumasaka, Sue E. Knoblaugh, Lisa Y. Ngo, Brahm H. Segal, Yoichiro Iwakura, Clifford A. Lowell, Jessica A. Hamerman, Xin Lin, Tobias M. Hohl
Publikováno v:
Cell Reports, Vol 2, Iss 6, Pp 1762-1773 (2012)
Fluorescence can be harnessed to monitor microbial fate and to investigate functional outcomes of individual microbial cell-host cell encounters at portals of entry in native tissue environments. We illustrate this concept by introducing fluorescent
Externí odkaz:
https://doaj.org/article/94a86de78786411491d78235ccebd396
Autor:
Masami Nishiyama, Haruka Sato, Yuka Someya, K Kumasaka, Chiyohiko Shindoh, Wakako Satoh, Masahito Miura, Ayana Matsumoto, Taiki Hasegawa
Publikováno v:
Heart and Vessels. 36:568-576
In non-diabetic patients with severe disease, such as acute myocardial infarction or acute heart failure, admission blood glucose level is associated with their short-term and long-term mortality. We examined whether transient elevation of glucose af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d893926d67b7450547e042fc0ee089c5
https://doi.org/10.1007/s00380-020-01726-6
https://doi.org/10.1007/s00380-020-01726-6
Publikováno v:
European Heart Journal. 42
Introduction Mechano-electric coupling (MEC) means that muscle stretching can induce action potentials. Stretch-activated channels (SACs) have been believed to play important roles in their induction. Purpose To investigate what degree of muscle stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51ffee9629fd81e9dff10a822d506b52
https://doi.org/10.1093/eurheartj/ehab724.3205
https://doi.org/10.1093/eurheartj/ehab724.3205
Autor:
Anupam Jhingran, Shinji Kasahara, Kelly M Shepardson, Beth A Fallert Junecko, Lena J Heung, Debra K Kumasaka, Sue E Knoblaugh, Xin Lin, Barbara I Kazmierczak, Todd A Reinhart, Robert A Cramer, Tobias M Hohl
Publikováno v:
PLoS Pathogens, Vol 11, Iss 1, p e1004589 (2015)
Aspergillus fumigatus forms ubiquitous airborne conidia that humans inhale on a daily basis. Although respiratory fungal infection activates the adaptor proteins CARD9 and MyD88 via C-type lectin, Toll-like, and interleukin-1 family receptor signals,
Externí odkaz:
https://doaj.org/article/e140aba6a5704c38aed93a6aecc95cef
Autor:
Chiyohiko Shindoh, M Nishiyama, Hideki Ota, Ryuta Kawashima, Haruka Sato, K Kumasaka, Y Someya, Wakako Satoh, T Ueda, Masahito Miura
Publikováno v:
European Heart Journal - Cardiovascular Imaging. 22
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): JSPS KAKENHI, Grant-in-Aid for Early-Career Scientists. Background Pulmonary arterial hypertension (PAH) remains a fatal disorder char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bc477b7f3e6d8d6e219be1c870c76c1
https://doi.org/10.1093/ehjci/jeab090.119
https://doi.org/10.1093/ehjci/jeab090.119
Autor:
Eric A. Horne, Patrick J. Cimino, Eric C. Holland, N. Wageling, Debra K. Kumasaka, Linda Wordeman, Daniel D Azorín, Ernest Hamel, Cong Xu, Michael Wagenbach, Philippe Diaz, Frank Winkler, Nephi Stella, Erik Jung
Publikováno v:
Neuro-oncology Advances
BackgroundGlioma is sensitive to microtubule-targeting agents (MTAs), but most MTAs do not cross the blood brain barrier (BBB). To address this limitation, we developed the new chemical entity, ST-401, a brain-penetrant MTA.MethodsSynthesis of ST-401
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bfc145b0391ed89f1823a0578d8834
https://doi.org/10.1093/noajnl/vdaa165
https://doi.org/10.1093/noajnl/vdaa165
Autor:
Michael Wagenbach, Erik Jung, Eric A. Horne, Eric C. Holland, Cong Xu, Juan Ruiz, Frank Winkler, Ernest Hamel, Linda Wordeman, Philippe Diaz, Nephi Stella, Patrick J. Cimino, Debra K. Kumasaka
Publikováno v:
Neuro Oncol
Most cancer therapeutics developed to date are excluded from the brain and are therefore ineffective in treating glioma, the most devastating type of brain cancer in adults. Microtubule targeting agents (MTAs) are indispensable medicines to treat a w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b07f46801883bf4dca8218851d65f44
https://europepmc.org/articles/PMC7650914/
https://europepmc.org/articles/PMC7650914/
Autor:
Chiyohiko Shindoh, Masahito Miura, Haruka Sato, M Nishiyama, Wakako Satoh, K Kumasaka, Y Someya
Publikováno v:
European Heart Journal. 41
Introduction Connexin43 (Cx43) forms gap junction channels in ventricular muscle and also exits in the inner mitochondrial membrane (mCx43). We have previously reported that carbenoxolone, a blocker of Cx43, increased the occurrence of arrhythmias wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed5f7fbfe02d5f8967dcc776aa1748ab
https://doi.org/10.1093/ehjci/ehaa946.3683
https://doi.org/10.1093/ehjci/ehaa946.3683