Zobrazeno 1 - 10
of 42
pro vyhledávání: '"K Kasdorf"'
Autor:
MJ Alfa, GKM Harding, AR Ronald, RB Light, N MacFarlane, N Olson, P DeGagne, K Kasdorf, A Simor, KS MacDonald, L Louie
Publikováno v:
Canadian Journal of Infectious Diseases, Vol 10, Iss 4, Pp 287-294 (1999)
OBJECTIVE: To monitor prospectively patients with Clostridium difficile-associated diarrhea (CAD) in a six hundred bed tertiary care hospital to determine which factors influenced the recurrence of the diarrhea.
Externí odkaz:
https://doaj.org/article/f3c21cdc5d5d4a84836e1a8c75348c32
Autor:
K Kasdorf, R. B. Light, L Louie, P. Degagne, G.K.M. Harding, Michelle J. Alfa, Kelly S. MacDonald, N. Olson, A. Simor, N MacFarlane, Allan R. Ronald
Publikováno v:
Canadian Journal of Infectious Diseases, Vol 10, Iss 4, Pp 287-294 (1999)
OBJECTIVE: To monitor prospectively patients withClostridium difficile-associated diarrhea (CAD) in a six hundred bed tertiary care hospital to determine which factors influenced the recurrence of the diarrhea.DESIGN: A prospective, nonrandomized stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f9c6155dbfe644fdfb12f834832c6a
https://doi.org/10.1155/1999/102891
https://doi.org/10.1155/1999/102891
Publikováno v:
Pure and Applied Chemistry. 69:383-388
FR-900848 is a pentacyclopropane nucleoside antifungal agent isolated from the fermentation broth of Streptoverricillium fervens. The full structure with relative and absolute stereochemistry of this unusual natural product were established by a comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4992a8041c76edf5ffca9417b576a396
https://doi.org/10.1351/pac199769030383
https://doi.org/10.1351/pac199769030383
Autor:
W. W. Doubleday, David J. Williams, Anthony G. M. Barrett, Andrew J. P. White, G. J. Tustin, K. Kasdorf, Dieter Hamprecht
Publikováno v:
Chemical Communications. :1693-1700
The full structural elucidation of FR-900848, an antifungal pentacyclopropane nucleoside natural product from Streptoverticillum fervens, is reported. A series of model compounds are prepared using multiple asymmetric Simmons–Smith cyclopropanation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f89ff5238dc8e2cc397e73c51e20c0a
https://doi.org/10.1039/a700487g
https://doi.org/10.1039/a700487g
Autor:
K. Kasdorf, Anthony G. M. Barrett
Publikováno v:
Journal of the American Chemical Society. 118:11030-11037
Quatercyclopropane 31 was oxidized, homologated, reduced, and monocyclopropanated to provide the pentacyclopropane alcohol 35. Subsequent deoxygenation of alcohol 35 was effected using N-(phenylthio)succinimide (24) and tributylphosphine followed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a908a79b29109955e9e038678ac0ff8
https://doi.org/10.1021/ja960964j
https://doi.org/10.1021/ja960964j
Publikováno v:
Journal of Heterocyclic Chemistry. 33:1545-1550
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1bf001e6a2eff42dca1de3e4f862a31
https://doi.org/10.1002/jhet.5570330510
https://doi.org/10.1002/jhet.5570330510
Publikováno v:
The Journal of Organic Chemistry. 61:3280-3288
Full structural elucidation of FR-900848, an antifungal pentacyclopropane nucleoside natural product from Streptoverticillium fervens, is reported. A series of model compounds were prepared using multiple asymmetric Simmons−Smith cyclopropanation r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad567e9034e08592f2c9c0ffbc243363
https://doi.org/10.1021/jo960054k
https://doi.org/10.1021/jo960054k
Publikováno v:
ChemInform. 25
Double asymmetric Simmons–Smith cyclopropanation and Whitham elimination were used to prepare (E)-1,2-bis-[(1S,2S)-2-methylcyclopropyl]ethane, the dicyclopropylethene unit of FR-900848.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20d3c1c2fdd465d623b4721658ebd88f
https://doi.org/10.1002/chin.199451295
https://doi.org/10.1002/chin.199451295
Autor:
W. W. Doubleday, David J. Williams, G. J. Tustin, Andrew J. P. White, K. Kasdorf, Anthony G. M. Barrett
Publikováno v:
ChemInform. 26
Two sequential asymmetric bicyclopropanation reactions were used to prepare (1R,3S,4R,6S,7S,9R,10S,12R)-quatercyclopropyl-1,12-dimethanol and (1S,3R,4R,6S,7S,9R,10R,12S)-quatercyclopropyl-1,12-dimethanol.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89340a114130fb387845b0439ad5c288
https://doi.org/10.1002/chin.199532114
https://doi.org/10.1002/chin.199532114
Publikováno v:
ChemInform. 26
Whitham elimination is used to prepare (Z)-1,2-bis[(1S,2S)-2-methylcyclopropyl]ethene, which along with the corresponding E-alkene, is used as a structural model to determine that the geometry of the dicyclopropylethene unit of FR-900848 is trans.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b67214f8b3e44c6c87e6f8e2fbf78871
https://doi.org/10.1002/chin.199531249
https://doi.org/10.1002/chin.199531249