Zobrazeno 1 - 10
of 115
pro vyhledávání: '"K K Khanna"'
Autor:
E. M. Poursani, D. Mercatelli, P. Raninga, J. L. Bell, F. Saletta, F. V. Kohane, Y. Zheng, J. Rouaen, T. R. Jue, F. T. Michniewicz, E. Kasiou, M. Tsoli, G. Cirillo, S. Waters, T. Shai-Hee, E. Valli, M. Brettle, R. Whan, L. Vahadat, D. Ziegler, J. G. Lock, F. M. Giorgi, K. K. Khanna, O. Vittorio
Copper is a trace element essential to cellular function with elevated levels implicated in cancer progression. Clinical trials using copper chelators are associated with improved patient survival, however, the molecular mechanisms by which copper de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31d0e2b4cac35b40f6068e3740b0affe
https://doi.org/10.1101/2022.10.03.510707
https://doi.org/10.1101/2022.10.03.510707
Autor:
Heather Thorne, A-M Patch, John F. Pearson, F Newell, Georgia Chenevix-Trench, Sriganesh Srihari, Vanessa Lakis, Katia Nones, Conrad Leonard, Sunil R. Lakhani, J Beasley, Peter T. Simpson, Michael T. Parsons, Mark A. Ragan, Aimee L Davidson, Amanda B. Spurdle, Andrea Degasperi, K. K. Khanna, Oliver Holmes, Julie K. Johnson, Kaltin Ferguson, Stephen H. Kazakoff, Serena Nik-Zainal, Scott Wood, Nick Waddell, Pamela Mukhopadhyay, Qinying Xu, X. M. De Luca, A.E. McCart Reed, Lynne Reid
Publikováno v:
Cancer Research. 79:P5-10
Approximately 10-15% of breast cancers are associated with a strong family history of disease. Pathogenic variants in BRCA1, BRCA2 or other moderate to highly penetrant susceptibility genes (e.g. TP53, ATM, CHEK2, PALB2 and PTEN) account for a number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::317682359e8da6428f3291f702dbfddd
https://doi.org/10.1158/1538-7445.sabcs18-p5-10-01
https://doi.org/10.1158/1538-7445.sabcs18-p5-10-01
Autor:
Fares Al-Ejeh, Ana Cristina Vargas, A. Hasson, Mariska Miranda, P. Kalita-de Croft, Peter T. Simpson, X. M. De Luca, Jamie R. Kutasovic, K. K. Khanna, Jonathan Beesley, Jodi M. Saunus, Emad A. Rakha, Ashwini Raghavendra, Georgia Chenevix-Trench, Julia Margaret Wendy Gee, Samir Lal, Emarene Kalaw, Irma Gresshoff, Korinne Northwood, Christopher J. Ormandy, Ian O. Ellis, Malcolm Lim, Andrew J. Dalley, A.E. McCart Reed, Andrew R. Green, Sunil R. Lakhani, Dan V. Nicolau
BackgroundIntratumoural heterogeneity is a poor prognostic feature in triple-negative breast cancer (TNBC) and other high-grade malignancies. It is caused by genomic instability and phenotypic plasticity, but how these features co-evolve during tumou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f92ff5d4512d02716e3d46a042bfc3e
https://doi.org/10.1101/2021.03.30.437624
https://doi.org/10.1101/2021.03.30.437624
Autor:
Juliet D. French, Mahdi Moradi Marjaneh, Fares Al-Ejeh, Mariska Miranda, Jason Sang Hun Lee, Francesco Casciello, Chatterjee O, Reed Aem, Adrian P. Wiegmans, Georgia Chenevix-Trench, Kutasovic, Peter T. Simpson, E Rozali, Jodi M. Saunus, Seckin Akgul, Herlina Y. Handoko, K. K. Khanna, Stacey L. Edwards, Wei Shi, Bryan W. Day, Lakhani, Tianqing Liu
BackgroundThe nucleocytoplasmic shuttling of ERK5 has gained recent attention as a regulator of its diverse roles in cancer progression but the exact mechanisms for this shuttling are still under investigation.MethodsUsing in vitro, in vivo and in si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2ab962a716be0c3fbd45cc509e53e25
https://doi.org/10.1101/2021.03.23.436061
https://doi.org/10.1101/2021.03.23.436061
Autor:
Stephen H. Kazakoff, Julie Johnson, Nicola Waddell, Oliver Holmes, Sunil R. Lakhani, K. K. Khanna, Conrad Leonard, Michael T. Parsons, Peter T. Simpson, Vanessa Lakis, Katia Nones, Serena Nik-Zainal, Aimee L Davidson, Scott Wood, Andrea Degasperi, Georgia Chenevix-Trench, A.E. McCart Reed, Lynne Reid, John V. Pearson, Ann-Marie Patch, Kaltin Ferguson, X. M. De Luca, Sriganesh Srihari, Jonathan M. Harris, Jonathan Beesley, Mark A. Ragan, David G. Barnes, Heather Thorne, Pamela Mukhopadhyay, Felicity Newell, Qinying Xu, Amanda B. Spurdle
Publikováno v:
Ann Oncol
Background Whole-genome sequencing (WGS) is a powerful method for revealing the diversity and complexity of the somatic mutation burden of tumours. Here, we investigated the utility of tumour and matched germline WGS for understanding aetiology and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a412216dcef79f04224ef9da58a55a6a
https://pubmed.ncbi.nlm.nih.gov/31090898
https://pubmed.ncbi.nlm.nih.gov/31090898
Publikováno v:
Indian Forester. 147:137
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64e270529c1843388bcc19d5870df9b7
https://doi.org/10.36808/if/2021/v147i2/155043
https://doi.org/10.36808/if/2021/v147i2/155043
Autor:
Murugan Kalimutho, J. Dunn, Anjum Zafar, Abel Tan, Christopher Sutton, Laeeq Malik, Andrew G. Bert, K. K. Khanna, Desmond Yip, Tara Boulding, Gregory J. Goodall, Fan Wu, Kristine Hardy, Jade K. Forwood, Sudha Rao, Jane E. Dahlstrom, Robert McCuaig
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
Scientific Reports
Scientific Reports
Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c42539811b2ffb99475722082110e1
http://link.springer.com/article/10.1038/s41598-019-55020-1
http://link.springer.com/article/10.1038/s41598-019-55020-1
Autor:
Andrew G. Bert, Anjum Zafar, Gregory J. Goodall, Abel Tan, Christopher Sutton, Jade K. Forwood, Tara Boulding, Kristine Hardy, Robert McCuaig, Laeeq Malik, Murugan Kalimutho, J. Dunn, Jane E. Dahlstrom, Sudha Rao, Desmond Yip, Fan Wu, K. K. Khanna
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
Scientific Reports
Scientific Reports
Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d23c03ffe7f3f7c6267d8f89708c259
https://doi.org/10.1038/s41598-017-17913-x
https://doi.org/10.1038/s41598-017-17913-x
Autor:
EB Butler, Nobuo Horikoshi, Vijay Charaka, CR Hunt, Ferid Murad, Walter N. Hittelman, Kalpana Mujoo, K. K. Khanna, Raj K. Pandita, Sharmistha Chakraborty, Alexander Y. Kots, Anjana Tiwari, Tej K. Pandita
Genomic integrity is critical for preservation of stem cell function and is, maintained through a robust DNA damage response (DDR) with systemized DNA DSB repair by either the non-homologous end joining (NHEJ) pathway or the homologous recombination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae5f1d65c69d5ad324d75779baa09e2
Publikováno v:
ESMO Open. 3:A309-A310
Introduction CEP55, discovered first by our laboratory, is a key regulator of cytokinesis, with perturbation of its levels causing cytokinesis failure and multi-nucleation. Since its discovery, CEP55 over-expression has been linked to increased aggre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::696972ef5485fb7d1c0f78d03d37da36
https://doi.org/10.1136/esmoopen-2018-eacr25.730
https://doi.org/10.1136/esmoopen-2018-eacr25.730