Výsledky vyhledávání

Cytokine and alloantibody networks in long term cardiac allografts in rat recipients treated with rapamycin

Autor: B Wasowska, K J Wieder, W W Hancock, X X Zheng, B Berse, J Binder, T B Strom, J W Kupiec-Weglinski

Publikováno v: The Journal of Immunology. 156:395-404

Treatment with rapamycin (RPM) prevents accelerated rejection of (LEW x BN)F1 cardiac allografts in LEW rats presensitized with BN skin grafts. This study analyzed the influence of RPM on cytokine (IL-2, IL-4, IL-10, and IL-12) and alloantibody netwo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5917d7672ab9b4b5f6faec86e10d44f
https://doi.org/10.4049/jimmunol.156.1.395

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CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines

Autor: J W Kupiec-Weglinski, B Wasowska, I Papp, G Schmidbauer, M H Sayegh, W M Baldwin, K J Wieder, W W Hancock

Publikováno v: The Journal of Immunology. 151:5053-5061

The accelerated (24 h) rejection of (LEWxBN)F1 cardiac allografts (Tx) in LEW rats sensitized with BN skin grafts, is abrogated with CD4 mAb (BWH-4) administration between skin (day -7) and heart (day 0) transplantation (Tx survival ca. 11 days, p <

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ea8ab326bd1abeb52a9f923a65278bc
https://doi.org/10.4049/jimmunol.151.9.5053

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Rapamycin treatment depresses intragraft expression of KC/MIP-2, granzyme B, and IFN-gamma in rat recipients of cardiac allografts

Autor: K J Wieder, W W Hancock, G Schmidbauer, C L Corpier, I Wieder, L Kobzik, T B Strom, J W Kupiec-Weglinski

Publikováno v: The Journal of Immunology. 151:1158-1166

Rapamycin (RPM) treatment prevents accelerated rejection of cardiac allografts in sensitized rats. The prominent feature of this brisk 24-h rejection, which includes a panoply of both cellular and humoral host immune responses, is a massive infiltrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::738e410f714c7f50c2e001816466d028
https://doi.org/10.4049/jimmunol.151.2.1158

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Evidence for functional heterogeneity of rat CD4+ T cells in vivo. Differential expression of IL-2 and IL-4 mRNA in recipients of cardiac allografts

Autor: I Papp, K J Wieder, T Sablinski, P J O'Connell, E L Milford, T B Strom, J W Kupiec-Weglinski

Publikováno v: The Journal of Immunology. 148:1308-1314

The in vivo relevance of functional dichotomy of CD4+ Th clones was studied by analyzing the induction of mRNA encoding for Th1- (IL-2) and Th2- (IL-4) specific lymphokines in a model of accelerated (24 h) cardiac allograft (Tx) rejection in presensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb849258893e14b879c3339a7bd03c3f
https://doi.org/10.4049/jimmunol.148.5.1308

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Transcriptional modulation of human IL-6 gene expression by verapamil

Autor: G Walz, B Zanker, C Barth, K J Wieder, S C Clark, T B Strom

Publikováno v: The Journal of Immunology. 144:4242-4248

Calcium channel-blocking agents interfere with the initial increase of cytosolic calcium that follows mitogenic stimulation of T lymphocytes. In cultures of mitogen-stimulated PBMC, verapamil also blocked T cell accumulation of cytoplasmic IL-2-encod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e2a16db3853965ca3c80d21e40ab92c
https://doi.org/10.4049/jimmunol.144.11.4242

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Cytokine and alloantibody networks in long-term cardiac allografts in rapamycin-treated sensitized rat recipients

Autor: B, Wasowska, K J, Wieder, W W, Hancock, B, Berse, J, Binder, T B, Strom, J W, Kupiec-Weglinski

Publikováno v: Transplantation proceedings. 27(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8cb1406bdd4e5db701eb0ae20f2fe800
https://pubmed.ncbi.nlm.nih.gov/7879047

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Some properties of polyethylene glycol:phenylalanine ammonia-lyase adducts

Autor: T. van Es, Nicholas C. Palczuk, K J Wieder, Frank F. Davis

Publikováno v: Journal of Biological Chemistry. 254:12579-12587

Methoxypolyethylene glycol of 5000 daltons (PEG) was attached covalently to phenylalanine ammonia-lyase from Rhodotorula glutinis. Attachment of sufficient quantities of PEG to phenylalanine ammonia-lyase substantially reduces immunological recogniti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c87f2fd204b014c7ac626153abf13422
https://doi.org/10.1016/s0021-9258(19)86354-8

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Enzyme-Polyethylene Glycol Adducts: Modified Enzymes with Unique Properties

Autor: Frank F. Davis, Nicholas C. Palczuk, R. Chen, Abraham Abuchowski, T. van Es, K J Wieder, K V Savoca

Publikováno v: Enzyme Engineering ISBN: 9781468469875

There are many clinical disorders which, in theory might be treated by the use of appropriate enzymes. However, there are serious problems associated with enzyme therapy. First, inadequate amounts of human enzymes are available; and most foreign enzy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b86141b260b6ced1228874a9436f5c99
https://doi.org/10.1007/978-1-4684-6985-1_35