Zobrazeno 1 - 10
of 24
pro vyhledávání: '"K J Watling"'
Publikováno v:
European Journal of Pharmacology. 182:465-472
Clozapine, an atypical neuroleptic drug devoid of extrapyramidal side effects, was a moderately potent, competitive inhibitor of the binding of [ 3 H]quaternised ICS 205–930 to 5-HT 3 receptor sites in rat cortical membranes, possessing a pK i valu
Publikováno v:
British Journal of Pharmacology. 99:767-773
1. The binding properties and pharmacological specificity of the selective NK3 tachykinin receptor agonist [3H))-senktide [( 3H]-succinyl[Asp6,MePhe8] substance P (6-11] have been examined in homogenates of guinea-pig ileum longitudinal muscle-myente
Publikováno v:
Annals of the New York Academy of Sciences. 632
Publikováno v:
British Journal of Pharmacology. 94:148-154
1. Tachykinin-stimulated inositol phospholipid hydrolysis was examined in slices of longitudinal muscle from guinea-pig ileum. 2. Substance P, neurokinin A and neurokinin B induced a concentration-dependent accumulation of total [3H]-inositol phospha
Autor:
R. Baker, S Aspley, Robert J. Barnaby, R G Jackson, N S Gee, C I Ragan, K J Watling, D C Billington, Paul D. Leeson, G G Reid
Publikováno v:
Biochemical Journal. 249:143-148
1. Hydrolysis of both enantiomers of inositol 1-phosphate and both enantiomers of inositol 4-phosphate to inositol is inhibited by LiCl in liver and brain. 2. The phosphatase activity is predominantly soluble. 3. Inositol 1,4-bisphosphate is also hyd
Publikováno v:
British Journal of Pharmacology. 90:211-217
Tachykinin-stimulated inositol phospholipid hydrolysis was examined in slices of hamster urinary bladder. In the presence of lithium, to inhibit inositol monophosphatase activity, substance P, eledoisin and related tachykinins induced large, dose-dep
Autor:
Leslie L. Iversen, K. J. Watling, Robin J. Breckenridge, Lindsey C. Williams, Sukhvinder S. Bansal, Colin J. Suckling
Publikováno v:
Biochemical Pharmacology. 34:4173-4177
Autor:
John L. Neumeyer, Ross J. Baldessarini, Nora S. Kula, K. J. Watling, Alexander Campbell, Dirk Reischig, George W. Arana
Publikováno v:
Journal of Medicinal Chemistry. 26:516-521
The enantiomers [(S)-(+) and (R)-(-)] of N-n-propylnorapomorphine (NPA) were synthesized. (R)-NPA was obtained by the acid-catalyzed rearrangement of N-n-propylnormorphine. (R)-NPA also was converted to (RS)-N-n-propylnorapomorphine dimethyl ether by
Publikováno v:
Biochemical Journal. 249:883-889
1. An inositol monophosphatase was purified to homogeneity from bovine brain. 2. The enzyme is a dimer of subunit Mr 29,000. 3. The enzyme hydrolyses both enantiomers of myo-inositol 1-phosphate and both enantiomers of myo-inositol 4-phosphate, but h
Autor:
K. J. Watling
Publikováno v:
Trends in Pharmacological Sciences. 9:227-229