Zobrazeno 1 - 10
of 12
pro vyhledávání: '"K J Tomaselli"'
Autor:
S Gaur, John Bertin, D J LaCount, R C Armstrong, S M Mendrysa, Paul D. Friesen, J F Krebs, K J Tomaselli
Publikováno v:
Journal of Virology. 70:6251-6259
Baculovirus p35 prevents programmed cell death in diverse organisms and encodes a protein inhibitor (P35) of the CED-3/interleukin-1 beta-converting enzyme (ICE)-related proteases. By using site-directed mutagenesis, we have identified P35 domains ne
Autor:
N C, Hoglen, B P, Hirakawa, C D, Fisher, S, Weeks, A, Srinivasan, A M, Wong, K L, Valentino, K J, Tomaselli, X, Bai, D S, Karanewsky, P C, Contreras
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 297(2)
Previous studies have shown that caspase inhibitors are effective at protecting against anti-Fas antibody (alpha-Fas)-mediated liver injury/lethality. The purpose of these experiments was to characterize more fully the efficacy of a broad-spectrum, i
Publikováno v:
Cancer research. 59(9)
Apoptotic changes of the nucleus induced by Fas (Apo1/CD95) stimulation are completely blocked by reducing intracellular ATP level. In this study, we examined the ATP-dependent step(s) of Fas-mediated apoptotic signal transduction using two cell line
Publikováno v:
The Journal of biological chemistry. 272(48)
Bcl-xL, an antiapoptotic member of the Bcl-2 family, inhibits programmed cell death in a broad variety of cell types. Recent reports have demonstrated that cytochrome c is released from mitochondria during apoptosis and have suggested that this relea
Autor:
T, Fernandes-Alnemri, A, Takahashi, R, Armstrong, J, Krebs, L, Fritz, K J, Tomaselli, L, Wang, Z, Yu, C M, Croce, G, Salveson
Publikováno v:
Cancer research. 55(24)
Recent evidence suggests that mammalian cysteine proteases related to Caenorhabditis elegans CED-3 are key components of mammalian programmed cell death or apoptosis. We have shown recently that the CPP32 and Mch2 alpha cysteine proteases cleave the
Autor:
L K, Simmons, P C, May, K J, Tomaselli, R E, Rydel, K S, Fuson, E F, Brigham, S, Wright, I, Lieberburg, G W, Becker, D N, Brems
Publikováno v:
Molecular pharmacology. 45(3)
Amyloid beta peptide (A beta), the major protein constituent of senile plaques in patients with Alzheimer's disease, is believed to facilitate the progressive neurodegeneration that occurs in the latter stages of this disease. Early attempts to chara
Autor:
K J, Tomaselli, D E, Hall, L A, Flier, K R, Gehlsen, D C, Turner, S, Carbonetto, L F, Reichardt
Publikováno v:
Neuron. 5(5)
Integrins mediate neuronal process outgrowth on components of the ECM. Integrin alpha subunit-specific antibodies have been used to examine the roles of individual beta 1 integrins in attachment and neurite outgrowth by the neuronal cell line, PC12,
Publikováno v:
The Journal of Immunology. 126:540-544
Modulation of a human common acute lymphoblastic leukemia antigen (CALLA) by specific monoclonal antibody (J5) has been studied with the immune precipitation method to identify radiolabeled antigen. Surfaces of leukemic cells have been labeled using
Autor:
Philip Stashenko, John M. Pesando, H Levine, K J Tomaselli, Edmond J. Yunis, Lee M. Nadler, Jerome Ritz, Herbert Lazarus, Stuart F. Schlossman
Publikováno v:
Human Immunology. 3:67-76
Three monoclonal antibodies have been used to isolate Ia-like antigens from three human cell lines; two of which are thought to be homozygous at the HLA-D/DR locus. Complete extraction of the Ia antigens identified by one antibody leaves those recogn
Publikováno v:
The Journal of Immunology. 131:2038-2045
CALLA is a 100,000-dalton surface glycoprotein expressed by malignant cells of patients with clinically important subtypes of acute leukemia. Incubation of human leukemic cells expressing CALLA with specific monoclonal antibody (J5) at 37 degrees C c