Zobrazeno 1 - 10
of 10
pro vyhledávání: '"K J Finney"'
Publikováno v:
Cell proliferation. 31(2)
In a previous study we reported that the NSAID sulindac had a marked inhibitory effect on the development of colonic tumours in mice treated with the carcinogen 1,2‐dimethylhydrazine (DMH). In this study we examined the effects of sulindac in respe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f43937bd5d99164bd6fcfa3d40b59a
https://pubmed.ncbi.nlm.nih.gov/9745616
https://pubmed.ncbi.nlm.nih.gov/9745616
Publikováno v:
Scopus-Elsevier
The in-vitro effects of hydroxyurea 5-FU and 5-FUdR have been extensively studied in experimental systems employing cell-line techniques. In this study we investigated the effects of these drugs on the levels of incorporation of labeled nucleosides i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4123c5336f66a021ef478c862b1db920
https://pubmed.ncbi.nlm.nih.gov/1748627
https://pubmed.ncbi.nlm.nih.gov/1748627
Autor:
Kathryn Elliott, K J Finney, Alexander J. Watson, Paul G. Ince, D R Appleton, Moganaden Moorghen
Publikováno v:
Carcinogenesis. 12(11)
An organ-culture system has been used to investigate the effect of certain gastrointestinal peptides on the morphology and cell proliferation of explants of azoxymethane (AOM)-treated colonic mucosa. Our aim was to ascertain whether such factors play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a79817d7f23af4ee0d3d87ad838baf
https://pubmed.ncbi.nlm.nih.gov/1934285
https://pubmed.ncbi.nlm.nih.gov/1934285
Autor:
James P. Sunter, Moganaden Moorghen, David R. Appleton, Paul G. Ince, Kathryn Elliott, Adrian L. Harris, Alexander J. Watson, K J Finney
Publikováno v:
Biochemical pharmacology. 41(8)
The in-vitro pharmacokinetics of vincristine (VCR) in normal rat colonic mucosa were studied. Two complementary approaches were adopted using an explant organ-culture system. Firstly [G-3H]vincristine (3HVCR) accumulation, retention and efflux were c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ef3cccbe88d04a55c51c1441f7f0c3
https://pubmed.ncbi.nlm.nih.gov/2009097
https://pubmed.ncbi.nlm.nih.gov/2009097
Publikováno v:
Anticancer research. 10(3)
Nineteen samples of primary colorectal carcinoma and adjacent mucosa were examined for EGFr expression using radioligand binding assays and immunohistochemical staining with the monoclonal antibody EGFR1. Radioligand binding experiments showed expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::752261491c5826f41e0e24b287dc8064
https://pubmed.ncbi.nlm.nih.gov/2195985
https://pubmed.ncbi.nlm.nih.gov/2195985
Publikováno v:
British Journal of Cancer
A morphological method has been developed allowing measurement of the effect on intestinal epithelia of vincristine. In routinely prepared tissue sections the proportion of mitotic events progressing beyond metaphase is counted by microscopy. When es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f720c2f144f22fbb054aea241d84289
https://doi.org/10.1038/bjc.1988.80
https://doi.org/10.1038/bjc.1988.80
Publikováno v:
British Journal of Cancer
A method is described enabling the direct measurement of vincristine resistance in intact tissues in vivo by morphological study. Using the metaphase arresting properties of the drug, counts were made of escaping anaphase and telophase mitotic figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60cfe9e4425c0179c702f33d2402a84
https://doi.org/10.1038/bjc.1985.232
https://doi.org/10.1038/bjc.1985.232
Publikováno v:
British Journal of Cancer
Verapamil increases the sensitivity of primary human colorectal carcinoma tissue to vincristine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f353bd3685dad05b92b5f317dea28531
https://doi.org/10.1038/bjc.1986.19
https://doi.org/10.1038/bjc.1986.19
Publikováno v:
The Journal of pathology. 156(4)
Sulindac, a non-steroidal anti-inflammatory drug, has been reported to lead to tumour regression in cases of human polyposis coli. We have investigated the effects of this drug on the growth of 1,2-dimethylhydrazine (DMH)-induced mouse colonic tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7447f6b2f2578b5561cb90e8964920a
https://pubmed.ncbi.nlm.nih.gov/3225717
https://pubmed.ncbi.nlm.nih.gov/3225717
Publikováno v:
Chemischer Informationsdienst. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f303c4162bc3c1de00f999ae2873601f
https://doi.org/10.1002/chin.197913083
https://doi.org/10.1002/chin.197913083