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Akademický článek

Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation

Autor: M. Glymenaki, A. Barnes, S. O’ Hagan, G. Warhurst, A. J. McBain, I. D. Wilson, D. B. Kell, K. J. Else, S. M. Cruickshank

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract Inflammatory bowel disease (IBD) is associated with altered microbiota composition and metabolism, but it is unclear whether these changes precede inflammation or are the result of it since current studies have mainly focused on changes afte

Externí odkaz: https://doaj.org/article/ba1deb3aefe84912bdbd91350647c562

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Caveolin1 interacts with the glucocorticoid receptor in the lung but is dispensable for its anti-inflammatory actions in lung inflammation and Trichuris Muris infection

Autor: G, Caratti, T, Poolman, R J, Hurst, L, Ince, A, Knight, K, Krakowiak, H J, Durrington, J, Gibbs, K J, Else, L C, Matthews, D W, Ray

Publikováno v: Scientific Reports

Glucocorticoids (Gcs) are widely prescribed anti-inflammatory compounds, which act through the glucocorticoid receptor (GR). Using an unbiased proteomics screen in lung tissue, we identified the membrane protein caveolin -1 (Cav1) as a direct interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3d489b4057c13e72627b32a8e3704c21
https://pubmed.ncbi.nlm.nih.gov/31189975

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Anti-inflammatory effects of infliximab in mice are independent of tumour necrosis factor α neutralization

Autor: M B, Assas, S E, Levison, M, Little, H, England, L, Battrick, J, Bagnall, J T, McLaughlin, P, Paszek, K J, Else, J L, Pennock

Publikováno v: Clinical and Experimental Immunology

Summary Infliximab (IFX) has been used repeatedly in mouse preclinical models with associated claims that anti‐inflammatory effects are due to inhibition of mouse tumour necrosis factor (TNF)‐α. However, the mechanism of action in mice remains u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98177ff3d0f046658034082e8d98b7b0
https://pubmed.ncbi.nlm.nih.gov/27669117

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Akademický článek

T. Muris Infection Dynamics of a Fresh, Wild Isolate: Is the Established E Isolate Still Relevant?

Autor: Mair I; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Bennett AR; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.; Wellcome Centre for Cell-Matrix Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Forman R; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Othman AA; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Logunova L; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Smith H; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Lowe AE; School of Life Sciences, University of Nottingham, Nottingham, UK., Bradley JE; School of Life Sciences, University of Nottingham, Nottingham, UK., Thornton DJ; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.; Wellcome Centre for Cell-Matrix Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Else KJ; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.

Publikováno v: Parasite immunology [Parasite Immunol] 2024 Nov; Vol. 46 (11), pp. e13072.

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Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris

Autor: R, Bowcutt, L V, Bell, M, Little, J, Wilson, C, Booth, P J, Murray, K J, Else, S M, Cruickshank

Publikováno v: Parasite Immunology

Alternatively activated macrophages (AAMs) have key roles in the immune response to a variety of gastrointestinal helminths such as Heligmosomoides bakeri and Nippostrongylus brasiliensis. In addition, AAMs have been implicated in the resolution of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79b23bc08acf7e11f43a4cf60686e2a4
https://pubmed.ncbi.nlm.nih.gov/21585399

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Cytokine production in BALB/c mice immunized with radiation attenuated third stage larvae of the filarial nematode, Brugia pahangi

Autor: A J Bancroft, R K Grencis, K J Else, E Devaney

Publikováno v: The Journal of Immunology. 150:1395-1402

BALB/c mice immunized with radiation attenuated third stage larvae of the filarial nematode Brugia pahangi are strongly immune to challenge infection. Investigation of the profile of cytokines secreted by spleen cells from immune mice stimulated in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4619a9418efc4fafa105b32ffd014a44
https://doi.org/10.4049/jimmunol.150.4.1395

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Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection

Autor: M, Svensson, L, Bell, M C, Little, M, DeSchoolmeester, R M, Locksley, K J, Else

Publikováno v: Parasite Immunology

Eosinophils have recently been demonstrated capable of localizing to lymph nodes that drain mucosal surfaces, in particular during T helper 2 (Th2) responses. Resistance of mice to infection with the gastrointestinal nematode Trichuris muris depends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9845f9cdeb66cfcbdd4930937400692d
https://pubmed.ncbi.nlm.nih.gov/21155838

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Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection

Autor: D, Artis, N E, Humphreys, C S, Potten, N, Wagner, W, Müller, J R, McDermott, R K, Grencis, K J, Else

Publikováno v: European journal of immunology. 30(6)

The ontogeny and function of gut-associated-lymphoid tissue is known to be critically dependent on the beta7 integrin subfamily. We have investigated the development of intestinal inflammation and pathogen-specific protective immunity to enteric helm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c3e732a23d7986cb2e67bf8778a7f05
https://pubmed.ncbi.nlm.nih.gov/10898502

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Intestinal nematode parasites, cytokines and effector mechanisms

Autor: K J, Else, F D, Finkelman

Publikováno v: International journal for parasitology. 28(8)

Laboratory models of intestinal nematode infection have played an important role in developing our understanding of the immune mechanisms that operate against infectious agents. The type of helper T cell response that develops following infection wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d302d775c36247ccb0261930cad14880
https://pubmed.ncbi.nlm.nih.gov/9762559

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Cellular immune responses to the murine nematode parasite Trichuris muris. I. Differential cytokine production during acute or chronic infection

Autor: K J, Else, R K, Grencis

Publikováno v: Immunology. 72(4)

A variety of T-cell parameters have been analysed in two H-2 compatible strains of mice, B10.BR and BALB/K, which differ in an absolute fashion in their ability to resist infection with the parasitic nematode Trichuris muris: BALB/K mice expel T. mur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6521738b5431f47faea8da2c3179f60f
https://pubmed.ncbi.nlm.nih.gov/1903765

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