Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis

Autor: S. Shankar, J. Stolp, S. C. Juvet, J. Beckett, P. S. Macklin, F. Issa, J. Hester, K. J. Wood

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Human regulatory B (Breg) cells have been difficult to study due to their scarcity and heterogeneity. Here the authors expand human B cells to exert immunosuppressive function in vitro and in vivo, and to implicate the TIM-1/STAT3 axis for the regula

Externí odkaz: https://doaj.org/article/02b7aeb86da34599b909177af4c5c1a6

CD1d/NKT cells (PP-006)

Autor: K. Kurimoto, X. Liu, E. Sekine-Kondo, K. Yamazaki, J. Yanping, L. L. Allan, M. Tsuji, Y. Andoh, T. Shigeura, J. Rossjohn, T. Maekawa, C. Wang, N. Dashtsoodol, L. P. Ho, S. Miura, X. Ruijing, D. I. Godfrey, J. M. Fletcher, M. Ciula, C. Li, Y. Guo, Y. Sonoda, D. G. Doherty, K. Hajipouran Benam, X. Wei, M. A. Jordan, T. Liu, A. M. Moodycliffe, T. Fujii, Y. Li, R. Sayeed, A. Frattini, H. Iwasaki, C. A. Benedict, C. Lang, E. Girardi, Y. Kinjo, H. Kikuchi, C. Perinu, T. Nakayama, N. D. Jones, M. Moll, K. Minamino, K. Kawana, Y. Taketani, D. Hohl, Ines Mrakovčić-Šutić, A. M. Stax, B. L. Macleod, C. Zhang, J. Jukes, A. J. Tyznik, K. J. Wood, Y. Harrak, Z. Rui, K. Kyparissoudis, P. Illarionov, S. Senju, S. Ryser, Y. Ichihara, L. Kjer-Nielsen, S. Zeng, B. Pei, Y. Chen, V. Costantino, J. McCluskey, Y. N. Nobori, J. Xiang, G. Cameron, R. Castaño, Y. Aoki, H. Ehara, J. Zhang, T. Tashiro, M. Zhang, M. Suzuki, M. Saitou, K. Onoé, M. Kinebuchi, D. Pellici, M. Kronenberg, N. Takahashi, D. G. Pellicci, W. Song, Y. Uemura, K. Tabeta, T. Nakajima, A. Matsuura, Z. Tian, B. Yongyi, Q. Wang, Y. Ji, Aleksandar Bulog, B. K. Chung, A. E. Hogan, R. Tan, D. M. Zajonc, N. Hirosawa, Z. Zhou, A. Llebaria, O. Ishihara, T. Yamashita, W. Yujuan, S. Chakravarti, A. G. Brooks, Y. Ikarashi, E. Tupin, P. Wang, R. Slattery, J. L. Vela, N. A. Nagarajan, S. Zhang, M. Inafuku, S. Fujii, T. Iyoda, M. Ushida, R. I. Staiano, X. Li, Y. Sakamoto, K. Kawakami, A. G. Baxter, J. Youxin, D. Zheng, H. Yuling, X. Jie, M. A. Exley, A. J. McMichael, D. Chen, H. Ogura, C. M. Barra, M. Triggiani, Y. Iwasawa, J. Matsumoto, Z. Lijun, M. J. Her, M. J. Smyth, L. Li, O. Patel, D. Godfrey, S. K. Andersson, A. Petraroli, A. Smed-Sörensen, K. Shimizu, H. Hyodo, H. Watarai, T. Taniguchi, H. Oku, T. Xinti, H. Watanabe, S. Porcelli, L. C. Sullivan, M. Taniguchi, G. S. Besra, T. Nagamatsu, S. Loffredo, J. Zhong, N. Hongo, M. Satoh, A. Mangoni, K. Inaba, Vladimir Mićović, S. Kozuma, T. Jinquan, S. Snelgrove, K. Mori, J. K. Sandberg, K. Iwabuchi, S. Janes, P. van den Elzen

Publikováno v: International Immunology. 22:i52-i57

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13dc1dbc29e6d20e2aaf2222fa8f8f25
https://doi.org/10.1093/intimm/dxq081

Cell therapy (DC, Treg, NKT) (PP-040)

Autor: Y. J. Chang, K. Tainton, Abbas Rezaei, K. Taniguchi, Y. C. Tsai, C. P. O'Neil, M. A. Swartz, N. Ilic, J. C. Wu, P. Neeson, M. Rosset, A. E. J. Yeoh, Y. Guo, E. Walker, D. Ritchie, M. Uzuki, M. Polanczyk, S. Berzins, D. Godfrey, S. Nikoo, S. Zhang, D. Gross, W. Lee, A. del Toro Arreola, A. Daneri Navarro, M. Bozorgmehr, M. Jeddi-Tehrani, J. Huang, L. Jimenez Perez, A. Duran Cardenas, Z. Vahedian, E. T. Akporiaye, E. Leeansyah, A. Akbari, K. J. Wood, R. Robles Garcia, A. A. Tomei, H. Quach, L. Sofronic-Milosavljevic, J. Davoust, T. Uchida, S. Velasco Ramirez, A. L. T. Yu, A. C. Chan, J. A. Hubbell, C. H. Wong, Y. Huang, F. E. Larios Jimenez, J. Chuang, S. V. Seow, L. E. Ling, C. Nembrini, K. Fujiki, B. Wei, J. K. Eby, D. Haley, S. del Toro Arreola, M. Colic, M. Prince, I. Majstorovic, M. Nakamura, A. Saquin, X. Zhang, A. E. Suarez Rincon, Massoumeh Ebtekar, Amir-Hassan Zarnani, J. Zhong, D. Campana, S. M. H. Chai, A. Gruden-Movsesijan, Y. Chen, P. L. Tan, K. Y. Dane, R. A. Franco Topete, G. Lui, D. Velluto

Publikováno v: International Immunology. 22:ii121-ii123

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc75270c88e10330bc894c9a4027ea90
https://doi.org/10.1093/intimm/dxq127

Gene therapy in transplantation

Autor: K J, Wood, T G, Prior

Publikováno v: Current opinion in molecular therapeutics. 3(4)

In transplantation, gene therapy strategies to prolong graft survival involve gene transfer and expression of immunomodulatory or graft-protecting molecules. The local production of immunosuppressive molecules has the potential to reduce their system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::16686a8779470ab967e5cfc47ae7a3fb
https://pubmed.ncbi.nlm.nih.gov/11525563

Induction of tolerance to alloantigen

Autor: O, Witzke, J A, Barbara, K J, Wood

Publikováno v: Reviews in immunogenetics. 1(3)

The study of transplantation tolerance has been a major area of immunological research since the pioneering work by Medawar and colleagues. It has been classically defined as the absence of an immune response to a specific antigen in the setting of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb60d794f36cd304f41159456609e599
https://pubmed.ncbi.nlm.nih.gov/11256428