HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6Chigh inflammatory monocytes in murine sepsis survivors

Autor: S I, Valdés-Ferrer, M, Rosas-Ballina, P S, Olofsson, B, Lu, M E, Dancho, M, Ochani, J H, Li, J A, Scheinerman, D A, Katz, Y A, Levine, L K, Hudson, H, Yang, V A, Pavlov, J, Roth, L, Blanc, D J, Antoine, S S, Chavan, U, Andersson, B, Diamond, K J, Tracey

Publikováno v: Journal of Internal Medicine

Background More than 500,000 hospitalized patients survive severe sepsis annually in the USA. Recent epidemiological evidence, however, demonstrated that these survivors have significant morbidity and mortality, with 3-year fatality rates higher than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::982134e9277ec7aff15cb1afe41ab080
http://europepmc.org/articles/PMC4223507

Alterations in Neuronal Nicotinic Acetylcholine Receptors in the Pathogenesis of Various Cognitive Impairments.

Autor: Guan, Zhi‐Zhong^1,2 (AUTHOR) zzg@gmc.edu.cn

Publikováno v: CNS Neuroscience & Therapeutics. Oct2024, Vol. 30 Issue 10, p1-14. 14p.

Organ Neuroprosthetics: Connecting Transplanted and Artificial Organs with the Nervous System.

Autor: Micera S; The BioRobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, 56127, Italy.; Interdisciplinary Research Center Health Science, Scuola Superiore Sant'Anna, Pisa, 56127, Italy.; Bertarelli Foundation Chair in Translational Neuroengineering, Neuro-X Institute, School of Engineering, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, 1015, Switzerland., Menciassi A; The BioRobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, 56127, Italy.; Interdisciplinary Research Center Health Science, Scuola Superiore Sant'Anna, Pisa, 56127, Italy., Cianferotti L; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, 50121, Italy., Gruppioni E; Centro Protesi INAIL, Budrio, 40054, Italy., Lionetti V; Interdisciplinary Research Center Health Science, Scuola Superiore Sant'Anna, Pisa, 56127, Italy.; UOSVD Anesthesia and Resuscitation, Fondazione Toscana G. Monasterio, Pisa, 56127, Italy.

Publikováno v: Advanced healthcare materials [Adv Healthc Mater] 2024 Sep; Vol. 13 (24), pp. e2302896. Date of Electronic Publication: 2024 Apr 24.

Anti-inflammatory effects of a new tumour necrosis factor-alpha (TNF-α) inhibitor (CNI-1493) in collagen-induced arthritis (CIA) in rats

Autor: K ÅKERLUND, H ERLANDSSON HARRIS, K J TRACEY, H WANG, T FEHNIGER, L KLARESKOG, J ANDERSSON, U ANDERSSON

Publikováno v: Clinical and Experimental Immunology. 115:32-41

SUMMARYA recently developed compound, a multivalent guanylhydrazone (CNI-1493) that inhibits TNF-α production by suppressing TNF-α translational efficiency, was administered in an experimental model of collagen type II-induced arthritis in DA rats.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4ca2df24b6eb5b367be7fe95ed4a26
https://doi.org/10.1046/j.1365-2249.1999.00750.x

Targeting the MCP‐GPX4/HMGB1 Axis for Effectively Triggering Immunogenic Ferroptosis in Pancreatic Ductal Adenocarcinoma.

Autor: Li, Ge¹ (AUTHOR), Liao, Chengyu² (AUTHOR), Chen, Jiangzhi¹ (AUTHOR), Wang, Zuwei^2,3 (AUTHOR), Zhu, Shuncang² (AUTHOR), Lai, Jianlin^2,3 (AUTHOR), Li, Qiaowei^4,5 (AUTHOR), Chen, Yinhao² (AUTHOR), Wu, Dihan² (AUTHOR), Li, Jianbo² (AUTHOR), Huang, Yi^2,6 (AUTHOR), Tian, Yifeng^2,3 (AUTHOR), Chen, Yanling¹ (AUTHOR) chenyanling@fjmu.edu.cn, Chen, Shi^2,3,4,5 (AUTHOR) wawljwalj@fjmu.edu.cn

Publikováno v: Advanced Science. 6/5/2024, Vol. 11 Issue 21, p1-21. 21p.