Zobrazeno 1 - 8
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pro vyhledávání: '"K J, Strissel"'
Autor:
J A, West-Mays, J R, Cook, P M, Sadow, D K, Mullady, P, Bargagna-Mohan, K J, Strissel, M E, Fini
Publikováno v:
Investigative ophthalmologyvisual science. 40(5)
Expression of the genes for collagenase and interleukin-1alpha (IL-1alpha) are induced as stromal cells become activated to the repair fibroblast phenotype after injury to the cornea. This investigation examines the mechanisms whereby expression of t
Publikováno v:
Investigative ophthalmologyvisual science. 40(3)
The matrix metalloproteinase gelatinase B is synthesized by cells at the leading edge of the corneal epithelium migrating to heal a wound. Recent data from the authors' laboratory suggest that excessive synthesis contributes to repair defects. The go
Publikováno v:
The Journal of experimental zoology. 278(4)
A temperature-dependent metastatic phenotype reported for a frog cell line, PNKT-4B, provided a means for studying potential mediators of cell-matrix interaction involved in metastatic invasion. Zymography revealed that these cells secreted enzyme sp
Publikováno v:
Investigative ophthalmologyvisual science. 38(7)
To explore the role of autocrine interleukin-1 alpha (IL-1 alpha) as a central regulator of the repair phenotype in corneal fibroblasts.Disruption of the actin cytoskeleton with cytochalasin B (CB), which mimics changes in shape that occur in repair
Publikováno v:
Investigative ophthalmologyvisual science. 38(2)
Classic studies have demonstrated that corneal epithelial cell density in culture can alter the balance of stimulatory and inhibitory cytokines controlling the elaboration of collagenolytic activity by co-cultured stromal cells. The current study att
Publikováno v:
Developmental genetics. 20(3)
The lens of the vertebrate eye was the classic model used to demonstrate the concepts of inductive interactions controlling development. However, it is in the Drosophila model that the greatest progress in understanding molecular mechanisms of eye de
Publikováno v:
Investigative ophthalmologyvisual science. 36(1)
To determine the molecular mechanisms whereby substances released by corneal epithelial cells act to inhibit the elaboration of collagenolytic activity by corneal stromal cells and to determine whether inhibitory activity might be mediated by interle
Publikováno v:
The Journal of biological chemistry. 269(15)
Stimulation of collagenase expression in cultures of normal diploid fibroblasts by the tumor promotor phorbol 12-myristate 13-acetate (PMA) occurs secondarily to synthesis of unknown intermediary proteins. We have investigated the hypothesis that a f