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Autor:
K J, Okolotowicz, W J, Lee, R F, Hartman, A Y, Kim, S R, Ottersberg, D E, Robinson, S R, Lefler, S D, Rose
Publikováno v:
Archiv der Pharmazie. 334(6)
Upon farnesylation by protein farnesyltransferase (FTase), key proteins become compartmentalized in cells. For example, cell membrane localization is essential for the mitogenic role of mutant Ras protein, which acts as a switch for cancer cell proli