Výsledky vyhledávání - "K J, Kopecky"

Correlation of multidrug resistance (MDR1) protein expression with functional dye/drug efflux in acute myeloid leukemia by multiparameter flow cytometry: identification of discordant MDR-/efflux+ and MDR1+/efflux- cases

Autor: Cheryl L. Willman, K. J. Kopecky, I-Ming Chen, John E. Godwin, David R. Head, F. R. Appelbaum, Catherine P. Leith, J. K. Weick

Publikováno v: Blood. 86:2329-2342

Resistance to chemotherapy is a major factor limiting successful treatment of acute myeloid leukemia (AML); one of the best characterized drug resistance mechanisms is extrusion of drugs by the energy-dependent multidrug resistance (MDR1) transport p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d127b61313532d52d4109851a64fc6a
https://doi.org/10.1182/blood.v86.6.2329.bloodjournal8662329

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Long-term follow-up of remission duration, mortality, and second malignancies in hairy cell leukemia patients treated with pentostatin

Autor: I W, Flinn, K J, Kopecky, M K, Foucar, D, Head, J M, Bennett, R, Hutchison, W, Corbett, P, Cassileth, T, Habermann, H, Golomb, K, Rai, E, Eisenhauer, F, Appelbaum, B, Cheson, M R, Grever

Publikováno v: Blood. 96(9)

The nucleoside analogue, pentostatin, has demonstrated high complete response rates and long relapse-free survival times in patients with hairy cell leukemia, a disease that historically had been unresponsive to treatment. Long-term data on duration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c1ee9d2f36a0beafc19968171c87af9b
https://pubmed.ncbi.nlm.nih.gov/11049974

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Twenty-four-color spectral karyotyping reveals chromosome aberrations in cytogenetically normal acute myeloid leukemia

Autor: F F, Zhang, J L, Murata-Collins, P, Gaytan, S J, Forman, K J, Kopecky, C L, Willman, F R, Appelbaum, M L, Slovak

Publikováno v: Genes, chromosomescancer. 28(3)

Multicolor spectral karyotyping allows simultaneous visualization of all human chromosomes and screening for chromosomal rearrangements without a priori knowledge of any abnormalities involved. Based on this potentially increased sensitivity, we inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30a1b228989a5c2b10e9206b84ef84a6
https://pubmed.ncbi.nlm.nih.gov/10862038

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Glutathione S-transferase theta 1 gene deletion and risk of acute myeloid leukemia

Autor: C, Crump, C, Chen, F R, Appelbaum, K J, Kopecky, S M, Schwartz, C L, Willman, M L, Slovak, N S, Weiss

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 9(5)

Individuals with a homozygous deletion of the glutathione S-transferase theta 1 (GSTT1) gene lack GSTT1 enzymatic detoxification of environmental carcinogens by conjugation with glutathione. The GSTT1 gene deletion has been associated with carcinogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::388bdddbc59aca29170c12ae2f8efbac
https://pubmed.ncbi.nlm.nih.gov/10815689

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A phase III comparison of high dose ARA-C (HIDAC) versus HIDAC plus mitoxantrone in the treatment of first relapsed or refractory acute myeloid leukemia Southwest Oncology Group Study

Autor: C, Karanes, K J, Kopecky, D R, Head, M R, Grever, H E, Hynes, E H, Kraut, R H, Vial, A, Lichtin, S, Nand, W E, Samlowski, F R, Appelbaum

Publikováno v: Leukemia research. 23(9)

The aim of this study is to determine whether the addition of mitoxantrone to high dose cytarabine improves the outcome of treatment in patients with relapsed or refractory acute myeloid leukemia (AML). One hundred and sixty-two eligible patients, 14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::965a358688fdce4e638558b6381ae05b
https://pubmed.ncbi.nlm.nih.gov/10475617

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Minimal residual disease in patients with hairy cell leukemia in complete remission treated with 2-chlorodeoxyadenosine or 2-deoxycoformycin and prediction of early relapse

Autor: M S, Tallman, D, Hakimian, K J, Kopecky, S, Wheaton, E, Wollins, K, Foucar, P A, Cassileth, T, Habermann, M, Grever, J M, Rowe, L C, Peterson

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(7)

The purine nucleoside analogues 2-chlorodeoxyadenosine (2-CdA) and 2'-deoxycoformycin (2'-DCF) induce complete remission (CR) in the majority of patients with hairy cell leukemia. However, minimal residual disease (MRD) has been detected in bone marr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::35d166da187f60bc324c3343d28977c6
https://pubmed.ncbi.nlm.nih.gov/10430066

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Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group Study

Autor: C P, Leith, K J, Kopecky, I M, Chen, L, Eijdems, M L, Slovak, T S, McConnell, D R, Head, J, Weick, M R, Grever, F R, Appelbaum, C L, Willman

Publikováno v: Blood. 94(3)

Therapeutic resistance is a major obstacle in the treatment of acute myeloid leukemia (AML). Such resistance has been associated with rapid drug efflux mediated by the multidrug resistance gene 1 (MDR1; encoding P-glycoprotein) and more recently with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03f6af77ba419abc19309a21bfc54783
https://pubmed.ncbi.nlm.nih.gov/10419902

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Estrogen receptor methylation is associated with improved survival in adult acute myeloid leukemia

Autor: Q, Li, K J, Kopecky, A, Mohan, C L, Willman, F R, Appelbaum, J K, Weick, J P, Issa

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(5)

Estrogen receptor methylation (ERM) is a frequent molecular alteration in adult acute myeloid leukemia (AML). In this study, we sought to determine the clinical characteristics and prognostic significance of ERM in AML. ERM was determined for 268 pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5907092c16ba524f94bf2d098bb37ced
https://pubmed.ncbi.nlm.nih.gov/10353741

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Malignant progenitors from patients with acute myelogenous leukemia are sensitive to a diphtheria toxin-granulocyte-macrophage colony-stimulating factor fusion protein

Autor: D E, Hogge, C L, Willman, R J, Kreitman, M, Berger, P D, Hall, K J, Kopecky, C, McLain, E P, Tagge, C J, Eaves, A E, Frankel

Publikováno v: Blood. 92(2)

We have previously demonstrated that human granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to a truncated diphtheria toxin (DT388-GMCSF) kills acute myelogenous leukemia (AML) cell lines bearing the GM-CSF receptor. We now report that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::683fc3fcaf72137404a8d9a1f734daec
https://pubmed.ncbi.nlm.nih.gov/9657759

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AML in the Elderly: a Biologically Distinct Disease in which MDR1 Expression and Unfavorable Cytogenetics Contribute to Poor Clinical Response. Studies of the Southwest Oncology Group

Autor: John E. Godwin, I-Ming Chen, Marilyn L. Slovak, D. R. Head, T. McConnell, K. J. Kopecky, Catherine P. Leith, Cheryl L. Willman, F. R. Appelbaum

Publikováno v: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ISBN: 9783642719622

Elderly patients with acute myeloid leukemia (AML) respond poorly to chemotherapy compared to younger cohorts. To determine the contribution of biologic factors to this poor response, we studied 211 patients (161 de novo, 50 secondary AML) over 55 ye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcbb49cfdc955ed57b8d9dee8cc2504f
https://doi.org/10.1007/978-3-642-71960-8_54

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