Výsledky vyhledávání - "K J, Guarino"

Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand

Autor: T, Rosen, T F, Seeger, S, McLean, M C, Desai, K J, Guarino, D, Bryce, K, Pratt, J, Heym, P M, Chalabi, J H, Windels

Publikováno v: Journal of Medicinal Chemistry. 36:3197-3201

The synthesis of a highly potent and selective NK 1 receptor antagonist radioligand, [ 3 H] -cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine (6a) is described. The in vitro binding pharmacology and autoradiographic distribution of 6a in guinea pig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a950b9db5c8a1ccce62eaf84d5f823ec
https://doi.org/10.1021/jm00073a022

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Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole

Autor: T, Rosen, T F, Seeger, S, McLean, A A, Nagel, J L, Ives, K J, Guarino, D, Bryce, J, Furman, R W, Roth, P M, Chalabi

Publikováno v: Journal of medicinal chemistry. 33(11)

4-(2-Methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole (5) is a highly potent member of a structurally novel series of selective serotonin-3 receptor antagonists. The synthesis of tritiated 5 and its binding profile in neuroblastoma-glioma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44ba59a4c982c74ebf80c9e12cc3dccd
https://pubmed.ncbi.nlm.nih.gov/2231600

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