Zobrazeno 1 - 10
of 10
pro vyhledávání: '"K J, Bame"'
Publikováno v:
The Biochemical journal. 337
Heparan sulphate proteoglycans on cell surfaces have been shown to mediate the degradation or recycling of several ligands. Since the interaction with ligand may affect proteoglycan catabolism once the complex is internalized, this could alter the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b04caf0b98fc6e7bbb53136ac68a3df2
https://pubmed.ncbi.nlm.nih.gov/9895290
https://pubmed.ncbi.nlm.nih.gov/9895290
Publikováno v:
The Journal of biological chemistry. 272(27)
Alzheimer's disease is characterized by senile plaques composed of polymeric fibrils of beta amyloid (Abeta), a 39-42-amino acid peptide formed after proteolytic processing of the amyloid precursor protein (betaAPP). Heparan sulfate proteoglycans hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bab687d503dd82fa9e599a59e89747f8
https://pubmed.ncbi.nlm.nih.gov/9202014
https://pubmed.ncbi.nlm.nih.gov/9202014
Publikováno v:
The Journal of biological chemistry. 272(4)
Once internalized, cell-associated heparan sulfate proteoglycans are degraded to short glycosaminoglycans by the action of endoglycosidases or heparanases. We have begun to address the question of how many heparanases are responsible for this process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2e587b1ed708aa33fe55b921bc2233c
https://pubmed.ncbi.nlm.nih.gov/8999930
https://pubmed.ncbi.nlm.nih.gov/8999930
Autor:
K J, Bame
Publikováno v:
The Journal of biological chemistry. 268(27)
The initial steps in the catabolism of cell-associated heparan sulfate proteolgycans in Chinese hamster ovary (CHO) cells are similar to what has been observed in other cells, cell surface proteoglycans are internalized and the heparan sulfate glycos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9c8e8886de896941b4ec2c11dc4e5c3
https://pubmed.ncbi.nlm.nih.gov/8376358
https://pubmed.ncbi.nlm.nih.gov/8376358
Publikováno v:
The Journal of biological chemistry. 266(19)
The coordination of N-deacetylation and N-sulfation of heparan sulfate was examined in wild-type Chinese hamster ovary cells and mutant pgsE-606. This mutant expresses about 3-fold less N-sulfotransferase activity, which causes the proportion of N-su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::725b1bb563e81c12a0aaf60a119153fe
https://pubmed.ncbi.nlm.nih.gov/2061321
https://pubmed.ncbi.nlm.nih.gov/2061321
Publikováno v:
The Journal of biological chemistry. 266(16)
A previous study identified a Chinese hamster ovary cell mutant, pgsE-606, which is defective in the N-sulfotransferase that catalyzes one of the initial polymer-modification reactions in the biosynthesis of heparan sulfate (Bame, K. J., and Esko, J.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::043acd111b03857a57a4edb9cedf8005
https://pubmed.ncbi.nlm.nih.gov/2037581
https://pubmed.ncbi.nlm.nih.gov/2037581
Publikováno v:
Methods in enzymology. 138
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1307e6851c6018f46aabf63a001df442
https://pubmed.ncbi.nlm.nih.gov/3298954
https://pubmed.ncbi.nlm.nih.gov/3298954
Publikováno v:
The Journal of biological chemistry. 261(22)
The lysosomal membrane enzyme acetyl-CoA:alpha-glucosaminide N-acetyltransferase catalyzes the transfer of the acetyl group from acetyl-CoA to terminal alpha-linked glucosamine residues of heparan sulfate. The reaction appears to be a transmembrane p
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https://explore.openaire.eu/search/publication?articleId=pmid________::6894b2df9a71d0d53b3c81fb4fc570de
https://pubmed.ncbi.nlm.nih.gov/3733705
https://pubmed.ncbi.nlm.nih.gov/3733705
Publikováno v:
The Journal of biological chemistry. 258(5)
Acetyl coenzyme A has been shown to be required for heparan sulfate degradation for the acetylation of terminal alpha-linked glucosamine residues (Klein, U., Kresse, H., and von Figura, K. (1978) Proc. Natl. Acad. Sci. U.S.A. 75, 5185-5189). We can n
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https://explore.openaire.eu/search/publication?articleId=pmid________::e83d24abcde152c78a634ad27d047905
https://pubmed.ncbi.nlm.nih.gov/6402508
https://pubmed.ncbi.nlm.nih.gov/6402508
Publikováno v:
The Journal of biological chemistry. 264(14)
Heparan sulfate N-sulfotransferase catalyzes the transfer of sulfate groups from adenosine 3'-phosphate, 5'-phosphosulfate to the free amino groups of glucosamine residues in heparan sulfate. We have identified a Chinese hamster ovary cell mutant, de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bcde1487ac0c5e90f14987100dffebeb
https://pubmed.ncbi.nlm.nih.gov/2524478
https://pubmed.ncbi.nlm.nih.gov/2524478