Zobrazeno 1 - 10
of 26
pro vyhledávání: '"K Ian White"'
Autor:
Yan Gao, Yousuf A. Khan, Weike Mo, K. Ian White, Matthew Perkins, Richard A. Pfuetzner, Josef G. Trapani, Axel T. Brunger, Teresa Nicolson
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112345- (2023)
Summary: The AAA+ NSF complex is responsible for SNARE complex disassembly both before and after membrane fusion. Loss of NSF function results in pronounced developmental and degenerative defects. In a genetic screen for sensory deficits in zebrafish
Externí odkaz:
https://doaj.org/article/fa469058d265459a95ab589acda03f97
Autor:
Kailu Yang, Chuchu Wang, Alex J. B. Kreutzberger, K. Ian White, Richard A. Pfuetzner, Luis Esquivies, Tomas Kirchhausen, Axel T. Brunger
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) introduced a relatively large number of mutations, including three mutations in the highly conserved heptad repeat 1 (HR1) region of the spike glycoprotein (S) critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45c4883d159c4a7d1431cf4a96acb4e6
https://doi.org/10.1073/pnas.2300360120
https://doi.org/10.1073/pnas.2300360120
Publikováno v:
eLife, Vol 7 (2018)
The recycling of SNARE proteins following complex formation and membrane fusion is an essential process in eukaryotic trafficking. A highly conserved AAA+ protein, NSF (N-ethylmaleimide sensitive factor) and an adaptor protein, SNAP (soluble NSF atta
Externí odkaz:
https://doaj.org/article/16de592c06514366be70c0596def7c4f
Autor:
Ucheor B Choi, Minglei Zhao, K Ian White, Richard A Pfuetzner, Luis Esquivies, Qiangjun Zhou, Axel T Brunger
Publikováno v:
eLife, Vol 7 (2018)
SNARE complex disassembly by the ATPase NSF is essential for neurotransmitter release and other membrane trafficking processes. We developed a single-molecule FRET assay to monitor repeated rounds of NSF-mediated disassembly and reassembly of individ
Externí odkaz:
https://doaj.org/article/b6ef30140f2c4082a52d6af39cbdac0b
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 57:156-187
ATPases associated with diverse cellular activities (AAA+ proteins) are a superfamily of proteins found throughout all domains of life. The hallmark of this family is a conserved AAA+ domain responsible for a diverse range of cellular activities. Typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6525ddca002878fad7e0a3ca73de35
https://doi.org/10.1080/10409238.2021.1979460
https://doi.org/10.1080/10409238.2021.1979460
Autor:
Kailu Yang, Chuchu Wang, Alex J. B. Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J. Eisen, K. Ian White, Richard G. Held, Subu Subramanian, Kendra Marcus, Richard A. Pfuetzner, Luis Esquivies, Catherine A. Doyle, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tom Kirchhausen, Axel T. Brunger
Publikováno v:
bioRxiv
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available COVID-19 vaccines and monoclonal antibody therapies through epitope change on the receptor binding domain of the viral spike glycoprotein. Hence, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ff3f156726e60f7df4ce4c7d4fff23
https://doi.org/10.1073/pnas.2210990119
https://doi.org/10.1073/pnas.2210990119
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available COVID-19 vaccines and monoclonal antibody therapies due to structural and dynamic changes of the viral spike glycoprotein (S). The heptad repeat 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b846c9d223712a51ccdee19d02ee31a5
https://doi.org/10.1073/pnas.2119467119
https://doi.org/10.1073/pnas.2119467119
Autor:
Kailu Yang, Chuchu Wang, Alex J.B. Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J. Eisen, K. Ian White, Richard Pfuetzner, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tomas Kirchhausen, Axel T. Brunger
Publikováno v:
Biophysical Journal. 122:322a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21524c0bc377dbfacb386449620421d1
https://doi.org/10.1016/j.bpj.2022.11.1802
https://doi.org/10.1016/j.bpj.2022.11.1802
Autor:
Lisa M. Monteggia, Rong Sun, Ok-Ho Shin, Pei-Yi Lin, K Ian White, Baris Alten, Qiangjun Zhou, Axel T. Brunger, Ege T. Kavalali, Luis Esquivies, Wendy K. Chung
Publikováno v:
Neuron. 109(1)
SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) complex, composed of synaptobrevin, syntaxin, and SNAP25, forms the essential fusion machinery for neurotransmitter release. Recent studies have reported several mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc60365e64b9b94698f8b796b9ca85f2
https://pubmed.ncbi.nlm.nih.gov/33412092
https://pubmed.ncbi.nlm.nih.gov/33412092
Structures of neurexophilin-neurexin complexes reveal a regulatory mechanism of alternative splicing
Autor:
Axel T. Brunger, Steven C Wilson, Richard A. Pfuetzner, K Ian White, Thomas C. Südhof, Ucheor B. Choi, Qiangjun Zhou
Publikováno v:
The EMBO Journal
Neurexins are presynaptic, cell‐adhesion molecules that specify the functional properties of synapses via interactions with trans‐synaptic ligands. Neurexins are extensively alternatively spliced at six canonical sites that regulate multifarious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb24e2c3ef66193aa11dd9dc35674ee
https://pubmed.ncbi.nlm.nih.gov/31566781
https://pubmed.ncbi.nlm.nih.gov/31566781