Zobrazeno 1 - 10
of 1 157
pro vyhledávání: '"K Hur"'
Autor:
Chan Hyoung Kim, Wi-jae Lee, Yeounsun Oh, Youngjeon Lee, Hyomin K. Lee, Jung Bae Seong, Kyung-Seob Lim, Sang Je Park, Jae-Won Huh, Young-Hyun Kim, Kyoung Mi Kim, Junho K. Hur, Seung Hwan Lee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The CRISPR-Cas nickase system for genome editing has attracted considerable attention owing to its safety, efficiency, and versatility. Although alternative effectors to Cas9 have the potential to expand the scope of genome editing, their ap
Externí odkaz:
https://doaj.org/article/7104cba81f98464089fea937ef604ff9
Autor:
Rajib Schubert, Taegeun Bae, Branko Simic, Sheena N. Smith, Seong-Ho Park, Gabriela Nagy-Davidescu, Viviana Gradinaru, Andreas Plückthun, Junho K. Hur
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Tyrosinase CRISPR knock out in the B16 melanoma cell line eliminates melanin production, with the lack of pigment not affecting tumour engraftment or growth and allowing for 3D imaging after clearing by PACT.
Externí odkaz:
https://doaj.org/article/6f1c0d373c3348b49dc96ba76bdb0d0a
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Terahertz (THz) radiation can affect the degree of DNA methylation, the spectral characteristics of which exist in the terahertz region. DNA methylation is an epigenetic modification in which a methyl (CH3) group is attached to cytosine, a n
Externí odkaz:
https://doaj.org/article/f3e108d4d14d4ce4b6bd1a6b0ef93749
Autor:
Jeonghun Kwon, Minyoung Kim, Woochang Hwang, Anna Jo, Gue-Ho Hwang, Minhee Jung, Un Gi Kim, Gang Cui, Heonseok Kim, Joon-Ho Eom, Junho K. Hur, Junwon Lee, Youngho Kim, Jin-soo Kim, Sangsu Bae, Jungjoon K. Lee
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract We present a novel genome-wide off-target prediction method named Extru-seq and compare it with cell-based (GUIDE-seq), in vitro (Digenome-seq), and in silico methods using promiscuous guide RNAs with large numbers of valid off-target sites.
Externí odkaz:
https://doaj.org/article/4edbb888a4dd403fbce800cf628179c6
Autor:
Han‐Eol Park, Song Hyun Jo, Rosalind H. Lee, Christian P. Macks, Taeyun Ku, Jihwan Park, Chung Whan Lee, Junho K. Hur, Chang Ho Sohn
Publikováno v:
Advanced Science, Vol 10, Iss 16, Pp n/a-n/a (2023)
Abstract Spatial transcriptomics is a newly emerging field that enables high‐throughput investigation of the spatial localization of transcripts and related analyses in various applications for biological systems. By transitioning from conventional
Externí odkaz:
https://doaj.org/article/0d314c6b20064328a975ad772c270f0c
Autor:
Sojin Kim, Tamrin Chowdhury, Hyeon Jong Yu, Jee Ye Kahng, Chae Eun Lee, Seung Ah. Choi, Kyung-Min Kim, Ho Kang, Joo Ho Lee, Soon-Tae Lee, Jae-Kyung Won, Kyung Hyun Kim, Min-Sung Kim, Ji Yeoun Lee, Jin Wook Kim, Yong-Hwy Kim, Tae Min Kim, Seung Hong Choi, Ji Hoon Phi, Young-Kyoung Shin, Ja-Lok Ku, Sungyoung Lee, Hongseok Yun, Hwajin Lee, Dokyoung Kim, Kyoungmi Kim, Junho K. Hur, Sung-Hye Park, Seung-Ki Kim, Chul-Kee Park
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background The activation of the telomere maintenance mechanism (TMM) is one of the critical drivers of cancer cell immortality. In gliomas, TERT expression and TERT promoter mutation are considered to reliably indicate telomerase activation
Externí odkaz:
https://doaj.org/article/f8118b5a57eb4e34a8c2820b80aa8ed9
Autor:
Hanseop Kim, Wi-jae Lee, Chan Hyoung Kim, Yeounsun Oh, Lee Wha Gwon, Hyomin Lee, Woojeung Song, Junho K. Hur, Kyung-Seob Lim, Kang Jin Jeong, Ki-Hoan Nam, Young-Suk Won, Kyeong-Ryoon Lee, Youngjeon Lee, Young-Hyun Kim, Jae-Won Huh, Bong-Hyun Jun, Dong-Seok Lee, Seung Hwan Lee
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 353-362 (2022)
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas12a system is composed of a Cas12a effector that acts as a DNA-cleaving endonuclease and a crispr RNA (crRNA) that guides the effector to the target DNA. It is considered a key
Externí odkaz:
https://doaj.org/article/ca3da64f7d3e427f968243ed76e0d3c6
Autor:
Yeo-Jun Yoon, Donghyun Kim, Kwon Yong Tak, Seungyeon Hwang, Jisun Kim, Nam Suk Sim, Jae-Min Cho, Dojin Choi, Yongmi Ji, Junho K. Hur, Hyunki Kim, Jong-Eun Park, Jae-Yol Lim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The long-term maintenance of diverse salivary gland cells remains challenging. Here the authors establish a protocol for long-term maintenance of murine and human salivary gland organoids exhibiting gland-specific gene expression, gland functions, an
Externí odkaz:
https://doaj.org/article/a2bef5aed8064dfe9c01da030644cd00
Autor:
Yeounsun Oh, Wi-jae Lee, Junho K. Hur, Woo Jeung Song, Youngjeon Lee, Hanseop Kim, Lee Wha Gwon, Young-Hyun Kim, Young-Ho Park, Chan Hyoung Kim, Kyung-Seob Lim, Bong-Seok Song, Jae-Won Huh, Sun-Uk Kim, Bong-Hyun Jun, Cheulhee Jung, Seung Hwan Lee
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Prime editing can induce a desired base substitution, insertion, or deletion in a target gene using reverse transcriptase after nick formation by CRISPR nickase. In this study, we develop a technology that can be used to insert or replace ex
Externí odkaz:
https://doaj.org/article/478d21aa92f94a34b52403f151d6642d
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0295458 (2023)
[This corrects the article DOI: 10.1371/journal.pone.0286632.].
Externí odkaz:
https://doaj.org/article/8f5a546e8c3849fcb6563b03731c31c4