Zobrazeno 1 - 10
of 68
pro vyhledávání: '"K Hestdal"'
Autor:
SI Helle, J Geisler, JP Poulsen, K Hestdal, K Meadows, W Collins, KM Tveit, JMP Holly, PE Lønning
Publikováno v:
British Journal of Cancer
Fourteen patients suffering from advanced colorectal (n = 7), pancreatic (n = 4) or gastric (n = 3) carcinomas received treatment with microencapsulated octreotide pamoate 90 mg i.m. every 4 weeks (n = 4), 160 mg i.m. every 4 weeks (n = 4) or 160 mg
Publikováno v:
The Journal of Immunology. 156:1415-1424
In addition to Ag presentation for T cell surveillance, MHC molecules have been implicated in mediating regulatory signals. We have assessed biologic responses following engagement of the TCR accessible region of the HLA class I alpha 2 domain. mAbs
Publikováno v:
Blood. 84:125-132
Interleukin-1 (IL-1) has been shown to stimulate hematopoietic progenitor cell growth both in vitro and in vivo. Although IL-1 alone lacks the ability to promote hematopoietic progenitor growth in vitro, it is a potent synergistic factor in combinati
Publikováno v:
Blood. 82:2991-2997
Several mechanisms have been proposed to explain the pathogenesis of severe congenital neutropenia (SCN); however, the mechanism(s) still remains unknown. In particular, clinical observations suggest that abnormal responsiveness of myeloid progenitor
Publikováno v:
The Journal of Immunology. 151:3215-3224
Monocyte/macrophage contribution of C biosynthesis is important, particularly during inflammation. Since granulocyte-macrophage CSF (GM-CSF) and macrophage-CSF (M-CSF) exert a variety of stimulatory effects on monocyte/macrophage functions in vitro,
Autor:
K Hestdal, SE Jacobsen, FW Ruscetti, CM Dubois, DL Longo, R Chizzonite, JJ Oppenheim, JR Keller
Publikováno v:
Blood. 80:2486-2494
To determine the mechanism(s) by which interleukin-1 (IL-1) promotes granulopoiesis in vivo, we examined the effect of in vivo administration of IL-1 alpha on colony-stimulating factor (CSF) receptor expression on bone marrow cells (BMCs) and whether
Publikováno v:
Blood. 78:2841-2847
Interleukin-1 (IL-1) has profound stimulatory effects on hematopoiesis but the mechanism(s) of action remain unknown. The direct action of IL- 1 on hematopoietic progenitor cells requires the presence of a specific IL-1 receptor (IL-1R). In this repo
Publikováno v:
The Journal of Immunology. 147:22-28
Murine bone marrow cells expressing the cell surface Ag RB6-8C5 were identified by fluorescence-activated cell-sorting analysis using a rat IgG mAb. The fluorescent intensity of RB6-8C5 was variable on bone marrow cells. This made it possible to sepa
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(12)
Activation-induced death of T cells regulates immune responses and is considered to involve apoptosis induced by ligation of Fas and TNF receptors. The role of other receptors in signaling T cell death is less clear. In this study we demonstrate that
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(9)
TCR binding to an MHC class I/peptide complex is a central event in CTL-mediated elimination of target cells. In this study, we demonstrate that specific activation of the TCR-binding region of the HLA-A2 class I alpha2 domain induces apoptotic cell