Zobrazeno 1 - 10
of 153
pro vyhledávání: '"K Heran, Darwin"'
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Mycobacterium tuberculosis is a major human pathogen and the causative agent of tuberculosis disease. M. tuberculosis is able to persist in the face of host-derived antimicrobial molecules nitric oxide (NO) and copper (Cu). However, M. tuber
Externí odkaz:
https://doaj.org/article/930ec61416c94acba7c9da73348084d7
Publikováno v:
mSphere, Vol 7, Iss 5 (2022)
ABSTRACT Mycobacterium tuberculosis possesses a Pup-proteasome system analogous to the eukaryotic ubiquitin-proteasome pathway. We have previously shown that the hexameric mycobacterial proteasome ATPase (Mpa) recruits pupylated protein substrates vi
Externí odkaz:
https://doaj.org/article/a184a9652e7149a79b867117d414e7d2
Autor:
K. Heran Darwin, Sarah A. Stanley
Publikováno v:
Open Biology, Vol 12, Iss 4 (2022)
There are many reactive intermediates found in metabolic pathways. Could these potentially toxic molecules be exploited for an organism's benefit? We propose that during certain microbial infections, the production of inherently reactive aldehydes by
Externí odkaz:
https://doaj.org/article/565aa2c91d304b289671c5e3ba5c7c9e
Autor:
Daisy X Ji, Kristen C Witt, Dmitri I Kotov, Shally R Margolis, Alexander Louie, Victoria Chevée, Katherine J Chen, Moritz M Gaidt, Harmandeep S Dhaliwal, Angus Y Lee, Stephen L Nishimura, Dario S Zamboni, Igor Kramnik, Daniel A Portnoy, K Heran Darwin, Russell E Vance
Publikováno v:
eLife, Vol 10 (2021)
Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriatel
Externí odkaz:
https://doaj.org/article/a13a048f3761473cb07137e4ffca8ea4
Autor:
Samuel H. Becker, Kathrin Ulrich, Avantika Dhabaria, Beatrix Ueberheide, William Beavers, Eric P. Skaar, Lakshminarayan M. Iyer, L. Aravind, Ursula Jakob, K. Heran Darwin
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT The bacterial pathogen Mycobacterium tuberculosis is the leading cause of death by an infectious disease among humans. Here, we describe a previously uncharacterized M. tuberculosis protein, Rv0991c, as a molecular chaperone that is activate
Externí odkaz:
https://doaj.org/article/f5ea186d359e44bc9800d53283f1b1a1
Publikováno v:
EMBO reports. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2bd90d5e90b153425661efa71e2405f
https://doi.org/10.15252/embr.202357041
https://doi.org/10.15252/embr.202357041
Mycobacterium tuberculosisis a major human pathogen and the causative agent of tuberculosis disease.M. tuberculosisis able to persist in the face of host-derived antimicrobial molecules nitric oxide and copper. However,M. tuberculosiswith defective p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c638696c8912e96aa1223b51fafb050
https://doi.org/10.1101/2023.02.11.528157
https://doi.org/10.1101/2023.02.11.528157
Autor:
Marie I. Samanovic, Hao-Chi Hsu, Marcus B. Jones, Victoria Jones, Michael R. McNeil, Samuel H. Becker, Ashley T. Jordan, Miroslav Strnad, Changcheng Xu, Mary Jackson, Huilin Li, K. Heran Darwin
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT It was recently reported that the human-exclusive pathogen Mycobacterium tuberculosis secretes cytokinins, which had only been known as plant hormones. While cytokinins are well-established, adenine-based signaling molecules in plants, they
Externí odkaz:
https://doaj.org/article/8cd03f758378472fbebf93b3106723bd
Autor:
Champak Chatterjee, Remco Merkx, Susan Zhang, Christa Schiesswohl, Paul P. Geurink, K. Heran Darwin, Gerbrand J. van der Heden van Noort, Huib Ovaa, Guido V. Janssen
Publikováno v:
ChemBioChem
ChemBioChem, 22(21), 3082-3089. WILEY-V C H VERLAG GMBH
Chembiochem
ChemBioChem, 22(21), 3082-3089. WILEY-V C H VERLAG GMBH
Chembiochem
Tuberculosis is a global health problem caused by infection with the Mycobacterium tuberculosis (Mtb) bacteria. Although antibiotic treatment has dramatically reduced the impact of tuberculosis on the population, the existence and spreading of drug r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b608c1a7078e3992ad73f9eb595eb50
https://doi.org/10.1002/cbic.202100333
https://doi.org/10.1002/cbic.202100333
Mycobacterium tuberculosisis a major human pathogen and the causative agent of tuberculosis disease. WhileM. tuberculosiscan persist in the presence of host-derived antimicrobials like nitric oxide and copper, bacteria defective for proteasome activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef5892d85f5f1e19e617fb495521ca44
https://doi.org/10.1101/2022.09.30.510424
https://doi.org/10.1101/2022.09.30.510424