Zobrazeno 1 - 10
of 846
pro vyhledávání: '"K H Lim"'
Autor:
Paul Trlin, Jenny Gong, Katie K. N. Tran, Vickie H. Y. Wong, Pei Ying Lee, Anh Hoang, Da Zhao, Leah C. Beauchamp, Jeremiah K. H. Lim, Andrew Metha, Kevin J. Barnham, David I. Finkelstein, Bang V. Bui, Phillip Bedggood, Christine T. O. Nguyen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Retinal hyperspectral imaging (HSI) is a non-invasive in vivo approach that has shown promise in Alzheimer’s disease. Parkinson’s disease is another neurodegenerative disease where brain pathobiology such as alpha-synuclein and iron over
Externí odkaz:
https://doaj.org/article/4922d8416bbd4e5ca8336a9df43afadf
Autor:
Qiu Xuan Tan, Nicholas B. Shannon, Weng Khong Lim, Jing Xian Teo, Daniel R. Y. Yap, Sze Min Lek, Joey W. S. Tan, Shih Jia J. Tan, Josephine Hendrikson, Ying Liu, Gillian Ng, Clara Y. L. Chong, Wanyu Guo, Kelvin K. N. Koh, Cedric C. Y. Ng, Vikneswari Rajasegaran, Jolene S.M. Wong, Chin Jin Seo, Choon Kiat Ong, Tony K. H. Lim, Bin Tean Teh, Oi Lian Kon, Claramae S. Chia, Khee Chee Soo, N. Gopalakrishna Iyer, Chin-Ann J. Ong
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionField cancerization is suggested to arise from imbalanced differentiation in individual basal progenitor cells leading to clonal expansion of mutant cells that eventually replace the epithelium, although without evidence.MethodsWe perform
Externí odkaz:
https://doaj.org/article/281912497fc44f628bdcedeb2a207a97
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The retina and brain share similar neurochemistry and neurodevelopmental origins, with the retina, often viewed as a “window to the brain.” With retinal measures of structure and function becoming easier to obtain in clinical populations there is
Externí odkaz:
https://doaj.org/article/4f44d9d2d9df41029a7cb8827aacbc71
Autor:
Dilshan Ariyarathna, Ajinkya Bhonsle, Joseph Nim, Colin K. L. Huang, Gabriella H. Wong, Nicholle Sim, Joy Hong, Kirrolos Nan, Andy K. H. Lim
Publikováno v:
Renal Failure, Vol 44, Iss 1, Pp 648-659 (2022)
Background Intraoperative hypotension is a risk factor for postoperative acute kidney injury (AKI). Elderly patients are susceptible due to reduced responses to acute hemodynamic changes.Aims Determine the association between hypotension identified f
Externí odkaz:
https://doaj.org/article/dfab320d33514e5bae0f7bb49c89acf5
Autor:
Marie J. Y. Reolo, Masayuki Otsuka, Justine Jia Wen Seow, Joycelyn Lee, Yun Hua Lee, Phuong H. D. Nguyen, Chun Jye Lim, Martin Wasser, Camillus Chua, Tony K. H. Lim, Wei Qiang Leow, Alexander Chung, Brian K. P. Goh, Pierce K. H. Chow, Ramanuj DasGupta, Joe Poh Sheng Yeong, Valerie Chew
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionDespite recent advances in immunotherapy for hepatocellular carcinoma (HCC), the overall modest response rate underscores the need for a better understanding of the tumor microenvironment (TME) of HCC. We have previously shown that CD38 i
Externí odkaz:
https://doaj.org/article/5a4cd342a33d48c3a5625cfed3c9b0ef
Autor:
Katie K. N. Tran, Vickie H. Y. Wong, Jeremiah K. H. Lim, Ali Shahandeh, Anh Hoang, David I. Finkelstein, Bang V. Bui, Christine T. O. Nguyen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract In addition to well characterized motor symptoms, visual disturbances are increasingly recognized as an early manifestation in Parkinson’s disease (PD). A better understanding of the mechanisms underlying these changes would facilitate the
Externí odkaz:
https://doaj.org/article/2ca2db10f64c4d158e15ba9dcf88633e
Autor:
Phuong H. D. Nguyen, Martin Wasser, Chong Teik Tan, Chun Jye Lim, Hannah L. H. Lai, Justine Jia Wen Seow, Ramanuj DasGupta, Cheryl Z. J. Phua, Siming Ma, Jicheng Yang, Sheena D/O Suthen, Wai Leong Tam, Tony K. H. Lim, Joe Yeong, Wei Qiang Leow, Yin Huei Pang, Gwyneth Soon, Tracy Jiezhen Loh, Wei Keat Wan, Chung Yip Chan, Peng Chung Cheow, Han Chong Toh, Alfred Kow, Yock Young Dan, Juinn Huar Kam, Shridhar Iyer, Krishnakumar Madhavan, Alexander Chung, Glenn K. Bonney, Brian K. P. Goh, Naiyang Fu, Victor C. Yu, Weiwei Zhai, Salvatore Albani, Pierce K. H. Chow, Valerie Chew
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
In order to design cancer immune therapies, it is important to understand how tumours evade the immune response that is mounted against them. Authors here analyse the distribution and properties of immune cells in hepatocellular carcinoma and describ
Externí odkaz:
https://doaj.org/article/2648047cd2d74e93ad29e2f0557f8fa3
Autor:
Amos H. P. Loh, Clara Angelina, Meng Kang Wong, Sheng Hui Tan, Sarvesh A. Sukhatme, Trifanny Yeo, Su Bin Lim, York Tien Lee, Shui Yen Soh, Wing Leung, Kenneth T. E. Chang, Yong Wei Chua, Syed M. F. Alkaff, Tony K. H. Lim, Chwee Teck Lim, Zhi Xiong Chen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Existing marker-based methods of minimal residual disease (MRD) determination in neuroblastoma do not effectively enrich for the circulating disease cell population. Given the relative size differential of neuroblastoma tumor cells over normal hemato
Externí odkaz:
https://doaj.org/article/59fd66efa5fa4cafad88aaaf99036c3c
Autor:
Jeremiah K. H. Lim, Qiao-Xin Li, Tim Ryan, Phillip Bedggood, Andrew Metha, Algis J. Vingrys, Bang V. Bui, Christine T. O. Nguyen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Hyperspectral imaging of the retina has recently been posited as a potentially useful form of spectroscopy of amyloid-beta (Aβ) protein in the eyes of those with Alzheimer’s disease (AD). The concept of using the retina as a biomarker for
Externí odkaz:
https://doaj.org/article/28ea0fabc8e749f5be0e21a89d4e8ea5
Autor:
Phuong H. D. Nguyen, Siming Ma, Cheryl Z. J. Phua, Neslihan A. Kaya, Hannah L. H. Lai, Chun Jye Lim, Jia Qi Lim, Martin Wasser, Liyun Lai, Wai Leong Tam, Tony K. H. Lim, Wei Keat Wan, Tracy Loh, Wei Qiang Leow, Yin Huei Pang, Chung Yip Chan, Ser Yee Lee, Peng Chung Cheow, Han Chong Toh, Florent Ginhoux, Shridhar Iyer, Alfred W. C. Kow, Yock Young Dan, Alexander Chung, Brian K. P. Goh, Salvatore Albani, Pierce K. H. Chow, Weiwei Zhai, Valerie Chew
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Intratumoural heterogeneity is a feature of liver cancer. Here, the authors demonstrate that heterogeneity exists at the immune cell level in liver cancer and show that tumours with high intratumoural immune heterogeneity demonstrated an immune suppr
Externí odkaz:
https://doaj.org/article/04bfa3244f6242d895349149a2c716b4