Zobrazeno 1 - 10
of 10
pro vyhledávání: '"K H, Sprugel"'
Publikováno v:
Blood. 88(9)
Severe suppression of the hematopoietic system is a major factor in limiting chemotherapy dose escalation. To determine whether a combination of human recombinant granulocyte colony-stimulating factor (G-CSF) and thrombopoietin (TPO) would alter reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34f57f77b685c879fc0ededc7010a91b
https://pubmed.ncbi.nlm.nih.gov/8896401
https://pubmed.ncbi.nlm.nih.gov/8896401
Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice
Publikováno v:
Experimental hematology. 24(10)
The recent cloning of thrombopoietin (TPO) has allowed us to study its in vivo effects in normal and myelosuppressed mice. Normal Balb/c mice were treated with recombinant human TPO (hTPO) at doses ranging from 1 to 20 kU for 7 days, and complete blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a8fad97931b726f209e2adfe456c85f
https://pubmed.ncbi.nlm.nih.gov/8765500
https://pubmed.ncbi.nlm.nih.gov/8765500
Publikováno v:
Experimental hematology. 24(2)
Thrombopoietin (Tpo), the ligand for the proto-oncogene receptor c-Mpl, increases megakaryocyte size, ploidy, and surface expression of platelet-specific glycoproteins, is inversely related to platelet mass, and is a potent in vivo stimulus of platel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db5b9f0f9cbc5a61bffb418b5a2d11f9
https://pubmed.ncbi.nlm.nih.gov/8641351
https://pubmed.ncbi.nlm.nih.gov/8641351
Publikováno v:
Blood. 86(10)
The activity of the c-Mpl ligand hematopoietic progenitors meets criteria expected for thrombopoietin (TPO). Bio-assays have shown that blood TPO levels are inversely related to platelet mass. We sought to identify the molecular basis for this regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9fea954d5e5ef435d4d8ac7d96e71709
https://pubmed.ncbi.nlm.nih.gov/7579332
https://pubmed.ncbi.nlm.nih.gov/7579332
Autor:
V. C. Broudy, J. Humes, K. H. Sprugel, N Lin, M. C. Bailey, T. Papayannopoulou, A. Grossmann, J. W. Forstrom, Kenneth Kaushansky, Hong Ping Ren
Publikováno v:
The Journal of clinical investigation. 96(3)
Thrombopoietin (TPO), the ligand for the receptor protooncogene c-mpl, has been cloned and shown to be the critical regulator of platelet production. Several features of c-Mpl expression, including its presence on erythroid cell lines, and the panmye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4107c43bee809b0bc0bd9e15664f686
https://pubmed.ncbi.nlm.nih.gov/7657840
https://pubmed.ncbi.nlm.nih.gov/7657840
Publikováno v:
Progress in clinical and biological research. 365
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::affc59309a1dfe34e395a2cd078a4e56
https://pubmed.ncbi.nlm.nih.gov/1862143
https://pubmed.ncbi.nlm.nih.gov/1862143
Publikováno v:
The American journal of pathology. 136(6)
To examine the effects of recombinant growth factors in vivo, impaired wound healing was studied in genetically diabetic C57BL/KsJ-db/db mice. Large full-thickness skin wounds made on the backs of these mice exhibited significant delays in the entry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5292ff7760194edb3cec61c9c8d8d2ef
https://pubmed.ncbi.nlm.nih.gov/2356856
https://pubmed.ncbi.nlm.nih.gov/2356856
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 255:H1165-H1172
To elucidate further the role of the platelet in the development of monocrotaline pyrrole (MCTP)-induced lung injury and pulmonary hypertension, MCTP-treated rats were made thrombocytopenic by cotreatment with an anti-rat platelet serum (PAS). Lung i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7373079cb13f3db46746b73d9541c5d
https://doi.org/10.1152/ajpheart.1988.255.5.h1165
https://doi.org/10.1152/ajpheart.1988.255.5.h1165
Publikováno v:
Progress in clinical and biological research. 266
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc158994c8099058d0857e337ea912f5
https://pubmed.ncbi.nlm.nih.gov/3380852
https://pubmed.ncbi.nlm.nih.gov/3380852
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 237(1)
Monocrotaline pyrrole (MCTP) causes endothelial cell damage, pulmonary hypertension and right ventricular hypertrophy in rats by an undetermined mechanism. A role for 5-hydroxytryptamine (5-HT) in the cardiopulmonary response to MCTP has been suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a7a0c2229fcccdff2fbe3cc08c3e3d6
https://pubmed.ncbi.nlm.nih.gov/2937908
https://pubmed.ncbi.nlm.nih.gov/2937908