Zobrazeno 1 - 10
of 797
pro vyhledávání: '"K H, Poon"'
Autor:
Georgia K. Atkin-Smith, Jascinta P. Santavanond, Amanda Light, Joel S. Rimes, Andre L. Samson, Jeremy Er, Joy Liu, Darryl N. Johnson, Mélanie Le Page, Pradeep Rajasekhar, Raymond K. H. Yip, Niall D. Geoghegan, Kelly L. Rogers, Catherine Chang, Vanessa L. Bryant, Mai Margetts, M. Cristina Keightley, Trevor J. Kilpatrick, Michele D. Binder, Sharon Tran, Erinna F. Lee, Walter D. Fairlie, Dilara C. Ozkocak, Andrew H. Wei, Edwin D. Hawkins, Ivan K. H. Poon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Endothelial cells are integral components of all vasculature within complex organisms. As they line the blood vessel wall, endothelial cells are constantly exposed to a variety of molecular factors and shear force that can induce cellular da
Externí odkaz:
https://doaj.org/article/12adadfbad504a22aba93116f2876b03
Autor:
Rhynelle S. Dmello, Michelle Palmieri, Pathum S. Thilakasiri, Larissa Doughty, Tracy L. Nero, Ashleigh R. Poh, Sarah Q. To, Erinna F. Lee, W. Douglas Fairlie, Lisa Mielke, Michael W. Parker, Ivan K. H. Poon, Eduard Batlle, Matthias Ernst, Ashwini L. Chand
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-13 (2024)
Abstract Excessive STAT3 signalling via gp130, the shared receptor subunit for IL-6 and IL-11, contributes to disease progression and poor survival outcomes in patients with colorectal cancer. Here, we provide evidence that bazedoxifene inhibits tumo
Externí odkaz:
https://doaj.org/article/edd38efeaa4746be83b35dd07210b0bf
Autor:
Jascinta P. Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K. Y. Yap, Kaiwen W. Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F. Rutter, Bo Shi, Gemma F. Ryan, Amy L. Hodge, Sarah Caruso, Amy A. Baxter, Dilara C. Ozkocak, Chad Johnson, Zoe I. Day, Alyce J. Mayfosh, Mark D. Hulett, Thanh K. Phan, Georgia K. Atkin-Smith, Ivan K. H. Poon
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-12 (2024)
Abstract Discovery of new small molecules that can activate distinct programmed cell death pathway is of significant interest as a research tool and for the development of novel therapeutics for pathological conditions such as cancer and infectious d
Externí odkaz:
https://doaj.org/article/62a57fe64f944d87ab3862e5bd598553
Autor:
Zoe I. Day, Alyce J. Mayfosh, Amy A. Baxter, Scott A. Williams, Joanne M. Hildebrand, Thomas F. Rau, Ivan K. H. Poon, Mark D. Hulett
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 555 (2024)
Here, we describe GS-9, a novel water-soluble fatty acid-based formulation comprising L-lysine and arachidonic acid, that we have shown to induce ferroptosis. GS-9 forms vesicle-like structures in solution and mediates lipid peroxidation, as evidence
Externí odkaz:
https://doaj.org/article/7ae74655cf7a41208939f28a5aa2a6ea
Autor:
Scott A. Williams, Fung T. Lay, Guneet K. Bindra, Suresh Banjara, Ivan K. H. Poon, Thanh Kha Phan, Marc Kvansakul, Mark D. Hulett
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Defensins are a class of host defence peptides that contribute to the immune system of eukaryotes. Here, the authors report the structure of saltwater crocodile defensin CpoBD13 and the mechanism of pH-dependent antifungal activity.
Externí odkaz:
https://doaj.org/article/34709b6a3e3f4e138fbe3e5c970854e2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/a51ad7a6088b4e8d919b69029fa6757f
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Extracellular vesicles (EVs) are membrane-bound particles released by cells in various (patho)physiological conditions. EVs can transfer effector molecules and elicit potent responses in recipient cells, making them attractive therapeutic agents and
Externí odkaz:
https://doaj.org/article/51c5a3ff79474d96b78f32533598a94c
Autor:
Tien K. Nguyen, Stephanie Paone, Enoch Chan, Ivan K. H. Poon, Amy A. Baxter, Shane R. Thomas, Mark D. Hulett
Publikováno v:
Cells, Vol 11, Iss 20, p 3198 (2022)
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and its management places a huge burden on healthcare systems through hospitalisation and treatment. Atherosclerosis is a chronic inflammatory disease of the arteria
Externí odkaz:
https://doaj.org/article/46bfd90df202454d8a17f3786326abb2
Autor:
Natalie J. Bitto, Lesley Cheng, Ella L. Johnston, Rishi Pathirana, Thanh Kha Phan, Ivan K. H. Poon, Neil M. O'Brien‐Simpson, Andrew F. Hill, Timothy P. Stinear, Maria Kaparakis‐Liaskos
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract Gram‐positive bacteria ubiquitously produce membrane vesicles (MVs), and although they contribute to biological functions, our knowledge regarding their composition and immunogenicity remains limited. Here we examine the morphology, conten
Externí odkaz:
https://doaj.org/article/4e974bc7551049d3a9a0104e038372a4
Autor:
Caroline Boulouis, Wan Rong Sia, Muhammad Yaaseen Gulam, Jocelyn Qi Min Teo, Yi Tian Png, Thanh Kha Phan, Jeffrey Y W Mak, David P Fairlie, Ivan K H Poon, Tse Hsien Koh, Peter Bergman, Chwee Ming Lim, Lin-Fa Wang, Andrea Lay Hoon Kwa, Johan K Sandberg, Edwin Leeansyah
Publikováno v:
PLoS Biology, Vol 18, Iss 6, p e3000644 (2020)
Mucosa-associated invariant T (MAIT) cells are abundant antimicrobial T cells in humans and recognize antigens derived from the microbial riboflavin biosynthetic pathway presented by the MHC-Ib-related protein (MR1). However, the mechanisms responsib
Externí odkaz:
https://doaj.org/article/1a7439938aa940da856fd9dd1aad64f2