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Downregulation of myogenic microRNAs in sub-chronic but not in sub-acute model of daunorubicin-induced cardiomyopathy

Autor: Peter Krenek, Peter Kruzliak, Jan Klimas, E. Malikova, Luis Rodrigo, Giampiero La Rocca, K. Galkova, Mariusz Adamek, Gabriel Doka

Publikováno v: Molecular and Cellular Biochemistry. 432:79-89

Cardiac muscle-related microRNAs play important roles in cardiac development and disease by translational silencing of mRNAs, the dominant mechanism of microRNA action. To test whether they could be involved in daunorubicin-associated cardiomyopathy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22345459bcdce00dc6e6ed6108159f2
https://doi.org/10.1007/s11010-017-2999-8

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Ramipril restores PPARβ/δ and PPARγ expressions and reduces cardiac NADPH oxidase but fails to restore cardiac function and accompanied myosin heavy chain ratio shift in severe anthracycline-induced cardiomyopathy in rat

Autor: E. Malikova, J. Srankova, Peter Krenek, Hana Cernecka, K. Galkova, Jan Klimas, Jan Kyselovic, L. Pivackova, Gabriel Doka

Publikováno v: European Journal of Pharmacology. 791:244-253

We hypothesized that peroxisome proliferator-activated receptors (PPARs) might be involved in a complex protective action of ACE inhibitors (ACEi) in anthracyclines-induced cardiomyopathy. For purpose of study, we compared effects of ramipril on card

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6255dae13d10e48d9ccab9f07441c2
https://doi.org/10.1016/j.ejphar.2016.08.040

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Local and systemic renin-angiotensin system participates in cardiopulmonary-renal interactions in monocrotaline-induced pulmonary hypertension in the rat

Autor: E. Malikova, Peter Krenek, Peter Vavrinec, Diana Vavrincova-Yaghi, Jan Klimas, Zuzana Kmecova, K. Galkova

Publikováno v: Molecular and cellular biochemistry. 418(1-2)

Renin-angiotensin system (RAS) is one of the pathophysiological mechanisms in heart failure. Recently, involvement of the kidney in the disease progression has been proposed in patients with pulmonary arterial hypertension (PAH). We hypothesized that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9c716e0327f2d4937e8514b05975c9
https://pubmed.ncbi.nlm.nih.gov/27344167

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[Diagnosis and immediate results of treatment of patients with non-epithelial tumors of upper gastrointestinal tract]

Autor: L M Mihaleva, E V Gorbachev, E D Fedorov, G N Goluhov, A I Mihalev, A E Sergeenko, S G Shapoval'jants, K Galkova, Dots Plahov

Publikováno v: Scopus-Elsevier

We presented an experience of treatment of 225 patients with non-epithelial tumors of upper gastrointestinal tract. Complicated disease's course was observed in 24% of cases. Tactical approaches are discussed depending on localization, dimensions and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67feda8d36fc1928c8cd063f9ad25e58
https://pubmed.ncbi.nlm.nih.gov/26081185

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PP.08.11

Autor: D. Vavrincova, Jan Klimas, K. Galkova, E. Malikova, Peter Krenek, Peter Vavrinec

Publikováno v: Journal of Hypertension. 33:e203

Objective:Monocrotaline induced pulmonary arterial hypertension is well known experimental model in rats. Undergoing processes in failing right ventricle are still not completely known. Heat shock protein 90 (Hsp90) seems to play a role in compensati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85c13b6f956ba072b8e6c7389f5c37f0
https://doi.org/10.1097/01.hjh.0000467963.83478.3f

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