Výsledky vyhledávání - "K G, Rendahl"

Regulation of gene expression in vivo following transduction by two separate rAAV vectors

Autor: Delphine Bohl, L. K. Cohen, M. Van Roey, K. G. Rendahl, Brian A. Donahue, Richard O. Snyder, Olivier Danos, Stuart E. Leff, Ronald J. Mandel, S. K. Spratt, G. R. Otten

Publikováno v: Nature Biotechnology. 16:757-761

Control of gene expression is important to gene therapy for purposes of both dosing and safety. In vivo regulation of gene expression was demonstrated following co-injection of two separate recombinant adeno-associated virus vectors, one encoding an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ceaca1fb86f556b7bef85d6b324318e
https://doi.org/10.1038/nbt0898-757

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In VivoL-DOPA Production by Genetically Modified Primary Rat Fibroblast or 9L Gliosarcoma Cell Grafts via Coexpression of GTPcyclohydrolase I with Tyrosine Hydroxylase

Autor: Ronald J. Mandel, K. G. Rendahl, Un Jung Kang, Stuart E. Leff, S. K. Spratt

Publikováno v: Experimental Neurology. 151:249-264

To investigate the biochemical requirements for in vivo L-DOPA production by cells genetically modified ex vivo in a rat model of Parkinson's disease (PD), rat syngeneic 9L gliosarcoma and primary Fischer dermal fibroblasts (FDFs) were transduced wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f184f9827f68b4e271a41aa1fdafe285
https://doi.org/10.1006/exnr.1998.6803

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Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2

Autor: D, Lau, L H, McGee, S, Zhou, K G, Rendahl, W C, Manning, J A, Escobedo, J G, Flannery

Publikováno v: Investigative ophthalmologyvisual science. 41(11)

We evaluated adeno-associated virus (AAV)-mediated gene transfer of basic fibroblast growth factor (FGF-2) as a therapy for photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa.Recombinant adeno-associated virus vector (rAAV)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::703e042969bc1dcc3e205b35af2de2b7
https://pubmed.ncbi.nlm.nih.gov/11006261

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Characterization of Intrastriatal Recombinant Adeno-Associated Virus-Mediated Gene Transfer of Human Tyrosine Hydroxylase and Human GTP-Cyclohydrolase I in a Rat Model of Parkinson’s Disease

Autor: Richard O. Snyder, K. G. Rendahl, S. K. Spratt, Stuart E. Leff, Ronald J. Mandel, Lawrence K. Cohen

To achieve local, continuousl-DOPA delivery in the striatum by gene replacement as a model for a gene therapy for Parkinson’s disease, the present studies used high titer purified recombinant adeno-associated virus (rAAV) containing cDNAs encoding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903b2a148d0f681c19245c6336ec1566
https://europepmc.org/articles/PMC6792786/

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