Zobrazeno 1 - 10 of 58 pro vyhledávání: '"K G, Chandy"'
1
Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes
Autor: Xueyou Hu, Yann Lefievre, Srikant Rangaraju, A. Orzel, K. P. Monaghan, K. G. Chandy, Satendra Chauhan, A. Garcia, Daniel Nugent, Taeko Inoue, Raymond S. Norton, Michael W. Pennington, Christine Beeton, Brian J. Smith, Igor V. Peshenko, Rebecca V. Moore, Charles A. Galea, A. Giuffrida, Ilya Khaytin, V. Chi, C. Dixon, D. Plank, George Crossley
Publikováno v: Molecular Pharmacology. 75:762-773
Kv1.3 potassium channels maintain the membrane potential of effector memory (T(EM)) T cells that are important mediators of multiple sclerosis, type 1 diabetes mellitus, and rheumatoid arthritis. The polypeptide ShK-170 (ShK-L5), containing an N-term
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb397c6a75b4c02f9b8afc8c8fded92
https://doi.org/10.1124/mol.108.052704
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2
Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21
Autor: Corinne Gehrig, Stylianos E. Antonarakis, J. Jay Gargus, Virginia K. Lasseter, Haig H. Kazazian, K G Chandy, Emmanuelle Fantino, David E. Housman, A. E. Pulver, George A. Gutman, Jean-Louis Blouin, Gerald Nestadt, K. Kalman, Uppala Radhakrishna
Publikováno v: American Journal of Medical Genetics. 88:348-351
To determine the importance of a candidate gene KCNN3 (formerly named hSKCa3) in the susceptibility to schizophrenia, we have studied the genotypes of a (CAG)n polymorphism within this gene in the DNAs of the members of 54 multiplex families with thi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff50121256dc610449010e958b31c8f8
https://doi.org/10.1002/(sici)1096-8628(19990820)88:4<348::aid-ajmg11>3.0.co
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3
Transmission Disequilibrium Analysis of a Triplet Repeat within thehKCa3Gene Using Family Trios with Schizophrenia
Autor: A. T. Bruinvels, Emmanuelle Fantino, K G Chandy, J. Jay Gargus, K. Kalman, George A. Gutman, E. Dawson, Xun Hu, RM Murray, Xiehe Liu, David A. Collier, Tao Li, Pak C. Sham, B. Freeman
Publikováno v: Biochemical and Biophysical Research Communications. 251:662-665
hKCa3 is a neuronal small conductance calcium-activated potassium channel which contains a polyglutamine tract, encoded by a polymorphic CAG repeat in the gene. Since an association between longer alleles of the CAG repeat and schizophrenia has been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef26baf0e9f6cb6d68001e0b693a5ec0
https://doi.org/10.1006/bbrc.1998.9484
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4
Two-dimensional crystallization and projection structure of KcsA potassium channel 1 1Edited by W. Baumeister
Autor: Peter J. Walian, K G Chandy, Seok-Yong Lee, S Ghanshani, Haixin Sui, C.L Wu, Huilin Li, Bing K. Jap
Publikováno v: Journal of Molecular Biology. 282:211-216
Potassium channels are integral membrane proteins that play a crucial role in regulating diverse cell functions in both electrically excitable and non-excitable cells. Molecular cloning has revealed a diverse family of genes that encode these protein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c495b15be3cb0e3070d74540e43dd09
https://doi.org/10.1006/jmbi.1998.2016
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5
Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia
Autor: Timothy Bowen, Kieran C. Murphy, Julie Williams, M. Y. Gray, George A. Gutman, Peter McGuffin, Carol Guy, Lesley Jones, Emmanuelle Fantino, J. Jay Gargus, Geraldine McCarthy, Gillian Spurlock, Rebecca Sanders, Michael John Owen, K. Kalman, Alastair G. Cardno, Michael Conlon O'Donovan, Nigel Williams, Nicholas John Craddock, K G Chandy
Publikováno v: Molecular Psychiatry. 3:266-269
A recent study has suggested that a polymorphism in the hKCa3 potassium channel may be associated with raised susceptibility to schizophrenia. Despite its modest statistical significance, the study is intriguing for two reasons. First, hKCa3 contains
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fca0972bcb6a2df1cded0094957c0a
https://doi.org/10.1038/sj.mp.4000400
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6
Full-length and truncated Kv1.3 K+ channels are modulated by 5-HT1c receptor activation and independently by PKC
Autor: K G Chandy, Jayashree Aiyar, Stephan Grissmer
Publikováno v: American Journal of Physiology-Cell Physiology. 265:C1571-C1578
In T-cells, the Shaker-related gene, Kv1.3 encodes the type n K+ channel, whereas the type l channel is a product of the Shaw. subfamily gene, Kv3.1. Both these genes are also expressed in the brain. We have used the Xenopus oocyte heterologous expre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c9189312aed9b8e31697486718b86e
https://doi.org/10.1152/ajpcell.1993.265.6.c1571
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7
The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells
Autor: John J. Wasmuth, George A. Gutman, Michael D. Cahalan, Brent A. Dethlefs, John Douglas Mcpherson, Sanjiv Ghanshani, K G Chandy, Stephan Grissmer
Publikováno v: Journal of Biological Chemistry. 267:20971-20979
T lymphocytes exhibit three distinct types of voltage-gated K+ channels, n, n', and l, that are distributed in the T cell lineage according to subset, as well as the cells' activation and developmental status. Type l K+ channels are found sparingly i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64284a14a822447f0a6c06c56f8f2646
https://doi.org/10.1016/s0021-9258(19)36784-5
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8
CD4-CD8- T cells from mice with collagen arthritis display aberrant expression of type l K+ channels
Autor: S Grissmer, D C Hanson, E J Natoli, M D Cahalan, K G Chandy
Publikováno v: The Journal of Immunology. 145:2105-2109
Expression of voltage-gated K+ channels in mAb-defined T cell subsets from normal mice and mice with experimental autoimmune arthritis was studied with the patch-clamp whole-cell recording technique in combination with fluorescence microscopy. CD4+CD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9122459df8e8233caf97f94035d2adca
https://doi.org/10.4049/jimmunol.145.7.2105
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10
Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia
Autor: Hiroaki Tomita, Vikram G. Shakkottai, G. Sun, William E. Bunney, George A. Gutman, Michael D. Cahalan, J. Jay Gargus, K G Chandy
Publikováno v: Molecular psychiatry. 8(5)
The small-conductance calcium-activated K(+) channel SK3 (SKCa3/KCNN3) regulates electrical excitability and neurotransmitter release in monoaminergic neurons, and has been implicated in schizophrenia, ataxia and anorexia nervosa. We have identified
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcac0a65165a939bd0847a542132309
https://pubmed.ncbi.nlm.nih.gov/12808432
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