Zobrazeno 1 - 10
of 553
pro vyhledávání: '"K Flaherty"'
Autor:
Ly Pham, Padmini Komalavilas, Alex M. Eddie, Timothy E. Thayer, Dalton L. Greenwood, Ken H. Liu, Jaclyn Weinberg, Andrew Patterson, Joshua P. Fessel, Kelli L. Boyd, Jenny C. Schafer, Jamie L. Kuck, Aaron C. Shaver, David K. Flaherty, Brittany K. Matlock, Christiaan D. M. Wijers, C. Henrique Serezani, Dean P. Jones, Evan L. Brittain, Jeffrey C. Rathmell, Michael J. Noto
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Cpt1a-dependent fatty acid beta-oxidation is found to regulate neutrophil trafficking to the site of infection in a mouse model of pneumonia and is found to play a role in pneumonia susceptibility in humans.
Externí odkaz:
https://doaj.org/article/d76a7386c54d4c2f854b839fc40b5550
Autor:
Andrew J. Siladi, Jing Wang, Andrea C. Florian, Lance R. Thomas, Joy H. Creighton, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Gregory C. Howard, Stephen W. Fesik, April M. Weissmiller, Qi Liu, William P. Tansey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent target for pharmacological inhibition in cancer. Small-molecule degraders of WDR5 ha
Externí odkaz:
https://doaj.org/article/4970649d70db445fb70eaa8e823937b6
Autor:
Anna E. Patrick, Kayla Shoaff, Tashawna Esmond, David M. Patrick, David K. Flaherty, T Brent Graham, Philip S. Crooke, Susan Thompson, Thomas M. Aune
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In juvenile idiopathic arthritis (JIA) inflammatory T cells and their produced cytokines are drug targets and play a role in disease pathogenesis. Despite their clinical importance, the sources and types of inflammatory T cells involved remain unclea
Externí odkaz:
https://doaj.org/article/dc42e2db61734440a0adf1c18b6b5635
Autor:
Diane C. Saunders, Kristie I. Aamodt, Tiffany M. Richardson, Alexander J. Hopkirk, Radhika Aramandla, Greg Poffenberger, Regina Jenkins, David K. Flaherty, Nripesh Prasad, Shawn E. Levy, Alvin C. Powers, Marcela Brissova
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)
Abstract Endogenous β cell regeneration could alleviate diabetes, but proliferative stimuli within the islet microenvironment are incompletely understood. We previously found that β cell recovery following hypervascularization-induced β cell loss
Externí odkaz:
https://doaj.org/article/9fc6488438814df2a6871457cb867bcb
Autor:
Aqeela Afzal, Eric E. Figueroa, Sujay V. Kharade, Kevin Bittman, Brittany K. Matlock, David K. Flaherty, Jerod S. Denton
Publikováno v:
Physiological Reports, Vol 7, Iss 23, Pp n/a-n/a (2019)
Abstract There has been a resurgence of interest in the volume‐regulated anion channel (VRAC) since the recent cloning of the LRRC8A‐E gene family that encodes VRAC. The channel is a heteromer comprised of LRRC8A and at least one other family mem
Externí odkaz:
https://doaj.org/article/1ed9b19f0c6b4c8cb960f91917af1c42
Autor:
Maria Roma, Colleen L. Marden, Marissa A. K. Flaherty, Samantha E. Jasion, Erica M. Cranston, Peter C. Rowe
Publikováno v:
Frontiers in Pediatrics, Vol 7 (2019)
Objective: The objectives of this study were to compare the health-related quality of life (HRQOL) of a North American population of adolescents and young adults with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) to (1) healthy controls
Externí odkaz:
https://doaj.org/article/d1cb30e14bbe4b71b6fa88ed31915478
Publikováno v:
A102. THE DEVELOPMENT, PROGRESSION, AND TREATMENT OF ILD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb85b53eb455a9a3e86070282328c28c
https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2576
https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2576
Autor:
Shan Meltzer, Katelyn C. Boulanger, Anda M. Chirila, Emmanuella Osei-Asante, Michelle DeLisle, Qiyu Zhang, Brian T. Kalish, Aniqa Tasnim, Erica L. Huey, Leah C. Fuller, Erin K. Flaherty, Tom Maniatis, Andrew M. Garrett, Joshua A. Weiner, David D. Ginty
Publikováno v:
Neuron.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b03cfe3d34dfa28d96cff9fa7e44281
https://doi.org/10.1016/j.neuron.2023.03.012
https://doi.org/10.1016/j.neuron.2023.03.012
Autor:
Heini M Natri, Christina B Del Azodi, Lance Peter, Chase J Taylor, Sagrika Chugh, Robert Kendle, Mei-i Chung, David K Flaherty, Brittany K Matlock, Carla L Calvi, Timothy S Blackwell, Lorraine B Ware, Matthew Bacchetta, Rajat Walia, Ciara M Shaver, Jonathan A Kropski, Davis J McCarthy, Nicholas E Banovich
Publikováno v:
bioRxiv
Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis (PF). Defining the genetic control of gene expression in a cell-type-specific and context-dependent manner is critical for understanding the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb33f8d2914884f147f02fc19d6ac0f
https://europepmc.org/articles/PMC10055257/
https://europepmc.org/articles/PMC10055257/
Publikováno v:
63. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V..
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c76869702904f05d70932b1ea2fa39c4
https://doi.org/10.1055/s-0043-1761000
https://doi.org/10.1055/s-0043-1761000