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pro vyhledávání: '"K F Kadow"'
Publikováno v:
The Journal of Immunology. 150:5241-5251
Granulocyte-macrophage (GM)-CSF is an important hematopoietic cytokine that regulates proliferation and differentiation of macrophages, neutrophils, and eosinophils. In this study, we generated mAb to five synthetic peptides that correspond to region
Autor:
P A, Trail, D, Willner, J, Knipe, A J, Henderson, S J, Lasch, M E, Zoeckler, M D, TrailSmith, T W, Doyle, H D, King, A M, Casazza, G R, Braslawsky, J, Brown, S J, Hofstead, R S, Greenfield, R A, Firestone, K, Mosure, K F, Kadow, M B, Yang, K E, Hellström, I, Hellström
Publikováno v:
Cancer research. 57(1)
The internalizing anti-Le(y) monoclonal antibody (MAb) BR64 was conjugated to the anticancer drug doxorubicin (DOX) using an acid-labile hydrazone bond to the DOX and either a disulfide or thioether bond to the MAb. The resulting disulfide (BR64-SS-D