Zobrazeno 1 - 5
of 5
pro vyhledávání: '"K F, Wright"'
Autor:
H J, Showell, M J, Conklyn, R, Alpert, G P, Hingorani, K F, Wright, M A, Smith, E, Stam, E D, Salter, D N, Scampoli, S, Meltzer, L A, Reiter, K, Koch, A D, Piscopio, S R, Cortina, A, Lopez-Anaya, E R, Pettipher, A J, Milici, R J, Griffiths
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(3)
CP-195543 [(+)-2-(3-benzyl-4-hydroxy-chroman-7-yl)-4-trifluoromethyl-benzoic acid] is a structurally novel, selective and potent leukotriene B4 (LTB4) receptor antagonist. In vitro CP-195543 inhibited [3H]LTB4 binding to high-affinity LTB4 receptors
Publikováno v:
Canadian journal of physiology and pharmacology. 75(8)
CP-80,633, a selective phosphodiesterase (PDE) 4 inhibitor, potently reverses histamine bronchoconstriction in anesthetized guinea pigs (ED50 10 micrograms/kg) but only weakly relaxes histamine-constricted guinea pig trachea (EC50 137 microM). Using
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(3)
Previous attempts to discern and quantify the selectivity of agonists for A1 versus A2 adenosine receptors in vivo have been confounded by the activation of baroreceptor reflexes and/or simultaneous expression of responses to both A1 and A2 receptor
Publikováno v:
Advances in prostaglandin and thromboxane research. 6
Publikováno v:
Artery. 10(6)
Tranylcypromine (TCP), which can inhibit prostacyclin (PGI2) synthesis in vitro, has been shown to facilitate platelet aggregation in damaged cerebral arterioles of the mouse when given intraperitoneally (50 mg/kg) one hour before inducing aggregatio