Zobrazeno 1 - 10
of 21
pro vyhledávání: '"K F, Bastow"'
Publikováno v:
ChemInform. 27
Autor:
Chairul Chairul, Yasuhiro Imakura, Y. Hayashi, R. Marumoto, Shinsuke Yamashita, H. Hara, K.‐H. Lee, N. Maruyama, K. F. Bastow
Publikováno v:
ChemInform. 29
Autor:
K. F. Bastow
Publikováno v:
Current drug targets. Infectious disorders. 4(4)
Modern biomedicinal research with acridones began with plant secondary metabolites but the successful development of these alkaloids into drugs has yet to be realized. However, there are synthetic acridones unrelated to the natural products now emerg
Autor:
P, Krishnan, K F, Bastow
Publikováno v:
Anti-cancer drug design. 15(4)
A current model suggests that the intercalative and minor groove binding components of protoberberines and related compounds are important for DNA topoisomerase I and/or II inhibition. The significance of the 9-substituent in berberine on drug-topois
Autor:
Z, Xu, F R, Chang, H K, Wang, Y, Kashiwada, A T, McPhail, K F, Bastow, Y, Tachibana, M, Cosentino, K H, Lee
Publikováno v:
Journal of natural products. 63(12)
Two new sesquiterpenes, leitneridanin A (1) and leitneridanin B (2), and seven known compounds, lirioresinol B, (-)-pinoresinal, (+)-lariciresinol, quassimarin (3), simalikalactone D (4), 1-methoxycanthinone (5), and 5-methoxycanthinone (6), were iso
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(23)
Twenty-six beta-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. Al
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(20)
Eleven resveratrol oligomers and six acetylated derivatives were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. The acetate of (-)-ampelopsin A (12) showed potent and selective cytotoxic activity with ED50 values of 0.
Autor:
J R, Vance, K F, Bastow
Publikováno v:
Biochemical pharmacology. 58(4)
Previously we reported that the antiproliferative and antiviral actions of 7-chloro-1,3 dihydroxyacridone (compound 1) and its derivatives may be mediated through the inhibition of mammalian DNA topoisomerase II. In the present work, we have extended
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(5)
Several substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-ones and related compounds were synthesized and evaluated for their in vitro cytotoxicity against a panel of human tumor cell lines. The most active compound (3) showed significant cytot
Publikováno v:
Bioorganicmedicinal chemistry. 6(11)
Demethylation of colchiceinamide (2) and its analogues (3-10) afforded a novel class of mammalian DNA topoisomerase II inhibitors (2a-10a) without displaying tubulin inhibitory activity. All target compounds inhibited the catalytic activity of topois