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of 112
pro vyhledávání: '"K Ekman"'
Autor:
Freja K. Ekman, David S. Ojala, Maroof M. Adil, Paola A. Lopez, David V. Schaffer, Thomas Gaj
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 829-839 (2019)
Huntington’s disease (HD) is a currently incurable and, ultimately, fatal neurodegenerative disorder caused by a CAG trinucleotide repeat expansion within exon 1 of the huntingtin (HTT) gene, which results in the production of a mutant protein that
Externí odkaz:
https://doaj.org/article/9124d693316b4ce19eb68f74da73bd30
Autor:
Maroof M. Adil, Thomas Gaj, Antara T. Rao, Rishikesh U. Kulkarni, Christina M. Fuentes, Gokul N. Ramadoss, Freja K. Ekman, Evan W. Miller, David V. Schaffer
Publikováno v:
Stem Cell Reports, Vol 10, Iss 5, Pp 1481-1491 (2018)
Summary: Huntington disease (HD) is an inherited, progressive neurological disorder characterized by degenerating striatal medium spiny neurons (MSNs). One promising approach for treating HD is cell replacement therapy, where lost cells are replaced
Externí odkaz:
https://doaj.org/article/b27b11ade2474de7abfb1e9528cc602b
Autor:
Thomas Gaj, David S. Ojala, Paola A. Lopez, Freja K. Ekman, Maroof M. Adil, David V. Schaffer
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss, Pp 829-839 (2019)
Molecular Therapy. Nucleic Acids
Molecular therapy. Nucleic acids, vol 17
Molecular Therapy. Nucleic Acids
Molecular therapy. Nucleic acids, vol 17
Huntington’s disease (HD) is a currently incurable and, ultimately, fatal neurodegenerative disorder caused by a CAG trinucleotide repeat expansion within exon 1 of the huntingtin (HTT) gene, which results in the production of a mutant protein that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8261ced1578476985dbd6c1b6661bcdc
http://www.sciencedirect.com/science/article/pii/S2162253119301994
http://www.sciencedirect.com/science/article/pii/S2162253119301994
Autor:
David V. Schaffer, Thomas Gaj, Evan W. Miller, Maroof M. Adil, Freja K. Ekman, Gokul N. Ramadoss, Rishikesh U. Kulkarni, Christina M. Fuentes, Antara T. Rao
Publikováno v:
Stem Cell Reports, Vol 10, Iss 5, Pp 1481-1491 (2018)
Stem cell reports, vol 10, iss 5
Stem Cell Reports
Adil, MM; Gaj, T; Rao, AT; Kulkarni, RU; Fuentes, CM; Ramadoss, GN; et al.(2018). hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model. Stem Cell Reports, 10(5), 1481-1491. doi: 10.1016/j.stemcr.2018.03.007. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/7v30n374
Stem cell reports, vol 10, iss 5
Stem Cell Reports
Adil, MM; Gaj, T; Rao, AT; Kulkarni, RU; Fuentes, CM; Ramadoss, GN; et al.(2018). hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model. Stem Cell Reports, 10(5), 1481-1491. doi: 10.1016/j.stemcr.2018.03.007. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/7v30n374
Summary Huntington disease (HD) is an inherited, progressive neurological disorder characterized by degenerating striatal medium spiny neurons (MSNs). One promising approach for treating HD is cell replacement therapy, where lost cells are replaced b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0e638734b11d9fa44d334d8805a56a
http://www.sciencedirect.com/science/article/pii/S2213671118301346
http://www.sciencedirect.com/science/article/pii/S2213671118301346
Autor:
Simo K. Ekman, Michel Debacker
Publikováno v:
Safety Science. 104:91-98
Globally, the risk of a commercial aircraft accident is low. The fatal accident rate of about 0.65 per million flights at the start of the 1990 s decreased to an average of one per 2.75 million flights for the five-year period 2010–2015. Research r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c83c95f7c040e3f9c6494f67ad723771
https://doi.org/10.1016/j.ssci.2017.12.039
https://doi.org/10.1016/j.ssci.2017.12.039
Akademický článek
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Autor:
David V. Schaffer, Thomas Gaj, Prajit Limsirichai, Leah C. Byrne, Freja K. Ekman, David S. Ojala
Publikováno v:
Science Advances
CRISPR-Cas9–mediated genome editing can be used to treat ALS in an animal model of the disease.
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease characterized by the progressive loss of motor neurons in th
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease characterized by the progressive loss of motor neurons in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2054e77d3ac7a5ebe635522bdeef88
http://europepmc.org/articles/PMC5738228
http://europepmc.org/articles/PMC5738228
Autor:
Prajit Limsirichai, Thomas Gaj, Freja K. Ekman, Brett T. Staahl, Jennifer A. Doudna, David V. Schaffer, Gonçalo M.C. Rodrigues
Publikováno v:
Nucleic Acids Research
Realizing the full potential of genome editing requires the development of efficient and broadly applicable methods for delivering programmable nucleases and donor templates for homology-directed repair (HDR). The RNA-guided Cas9 endonuclease can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28eccee9c443f2a984e7fde226f2a6d9
https://pubmed.ncbi.nlm.nih.gov/28334779
https://pubmed.ncbi.nlm.nih.gov/28334779
Publikováno v:
Injury. 43:2126-2131
Delayed time to surgery is associated with an increase in medical complications and delayed rehabilitation for hip-fracture patients. The aim of this study was to evaluate whether an improved fast-tracking system for hip-fracture patients can reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d002549df790e92623e4d0a51976ca83
https://doi.org/10.1016/j.injury.2012.05.017
https://doi.org/10.1016/j.injury.2012.05.017
Autor:
R Virtala, Mikael Adner, Mattias Fransson, Lars-Olaf Cardell, A. K. Ekman, L Jansson, Mikael Benson
Publikováno v:
International Archives of Allergy and Immunology. 159:6-14
Background: Allergic rhinitis is a systemic disorder, and it is clinically well recognized that it can be aggravated by infection. Activation of the innate immune system constitutes a critical element in the process. Toll-like receptors (TLRs) compri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43693c65de407bfb33f3a2338cda687
https://doi.org/10.1159/000335196
https://doi.org/10.1159/000335196